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Critical Care
Published in: Critical Care 1/2014

Open Access 01-02-2014 | Viewpoint

Renal recovery

Authors: Stuart L Goldstein, Lakhmir Chawla, Claudio Ronco, John A Kellum

Published in: Critical Care | Issue 1/2014

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Abstract

Acute kidney injury (AKI) research in the past decade has mostly focused upon development of a standard AKI definition, validation of early novel biomarkers to predict AKI prior to serum creatinine rise and predict AKI severity, and assessment of aspects of renal replacement therapies and their impact on survival. Given the independent association between AKI and mortality in the acute phase, such focus makes imminent sense. More recently, the recognition that AKI is associated with subsequent development of chronic kidney disease and end-stage renal disease, with the attendant increase in mortality, has led to interest in the clinical epidemiology and the mechanistic understanding of renal recovery after an AKI episode in critically ill patients. We review the current knowledge surrounding renal recovery after an AKI episode, including renal replacement therapy initiation timing and modality impact, biomarker assessment and mechanistic targets to guide potential future clinical trials.
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Metadata
Title
Renal recovery
Authors
Stuart L Goldstein
Lakhmir Chawla
Claudio Ronco
John A Kellum
Publication date
01-02-2014
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2014
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc13180

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