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Open Access 01-06-2013 | Research

The peripheral perfusion index and transcutaneous oxygen challenge test are predictive of mortality in septic patients after resuscitation

Authors: Huai-wu He, Da-wei Liu, Yun Long, Xiao-ting Wang

Published in: Critical Care | Issue 3/2013

Abstract

Introduction

The peripheral perfusion index (PI) is a noninvasive numerical value of peripheral perfusion, and the transcutaneous oxygen challenge test (OCT) is defined as the degree of transcutaneous partial pressure of oxygen (PtcO₂) response to 1.0 FiO_2. The value of noninvasive monitoring peripheral perfusion to predict outcome remains to be established in septic patients after resuscitation. Moreover, the prognostic value of PI has not been investigated in septic patients.

Methods

Forty-six septic patients, who were receiving PiCCO-Plus cardiac output monitoring, were included in the study group. Twenty stable postoperative patients were studied as a control group. All the patients inspired 1.0 of FiO₂ for 10 minutes during the OCT. Global hemodynamic variables, traditional metabolic variables, PI and OCT related-variables were measured simultaneously at 24 hours after PiCCO catheter insertion. We obtained the 10min-OCT ((PtcO₂ after 10 minutes on inspired 1.0 oxygen) - (baseline PtcO₂)), and the oxygen challenge index ((10min-OCT)/(PaO₂ on inspired 1.0 oxygen - baseline PaO₂)) during the OCT.

Results

The PI was significantly correlated with baseline PtcO₂, 10min-OCT and oxygen challenge index (OCI) in all the patients. The control group had a higher baseline PtcO₂, 10min-OCT and PI than the septic shock group. In the sepsis group, the macro hemodynamic parameters and ScvO₂ showed no differences between survivors and nonsurvivors. The nonsurvivors had a significantly lower PI, 10min-OCT and OCI, and higher arterial lactate level. The PI, 10min-OCT and OCI predicted the ICU mortality with an accuracy that was similar to arterial lactate level. A PI <0.2 and a 10min-OCT <66mmHg were related to poor outcome after resuscitation.

Conclusions

The PI and OCT are predictive of mortality for septic patients after resuscitation. Further investigations are required to determine whether the correction of an impaired level of peripheral perfusion may improve the outcome of septic shock patients.

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Title: The peripheral perfusion index and transcutaneous oxygen challenge test are predictive of mortality in septic patients after resuscitation
Authors: Huai-wu He
Da-wei Liu
Yun Long
Xiao-ting Wang
Publication date: 01-06-2013
Publisher: BioMed Central
Published in: Critical Care / Issue 3/2013
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc12788

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The peripheral perfusion index and transcutaneous oxygen challenge test are predictive of mortality in septic patients after resuscitation

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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