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Breast Cancer Research
Published in: Breast Cancer Research 4/2004

Open Access 01-08-2004 | Research article

S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situof the breast

Authors: Ethan D Emberley, Salem Alowami, Linda Snell, Leigh C Murphy, Peter H Watson

Published in: Breast Cancer Research | Issue 4/2004

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Abstract

Introduction

The S100A7 (psoriasin) gene is highly expressed in ductal carcinoma in situ (DCIS) of the breast and can be downregulated in invasive carcinoma. Persistent S100A7 expression in invasive carcinoma is associated with a worse prognosis, and this effect may be mediated in part through interaction with the multifunctional cell signaling protein Jab1.

Methods

In order to investigate the relationship between S100A7 and progression from DCIS to invasive carcinoma, we studied S100A7 expression in 136 patients with DCIS (including 46 patients with associated invasive carcinoma) by immunohistochemistry.

Results

S100A7 expression was present in 63 out of 136 (46%) of DCIS lesions and was associated with estrogen receptor negative status (P = 0.0002), higher nuclear grade (P < 0.0001), necrosis (P < 0.0001) and inflammation (P < 0.0001). S100A7 status was no different between DCIS with and DCIS without an invasive component, but higher levels of S100A7 were present in DCIS associated with invasive carcinoma (P < 0.004). Analysis of a subset of cases showed that S100A7 expression was also associated with an increase in nuclear Jab1 (n = 43; P = 0.0019) and reduced p27kip1 (n = 47; P = 0.0168). In cases of DCIS associated with invasive carcinoma, there was also a significant reduction in S100A7 between in situ and invasive components (n = 46; P < 0.0001). In pure DCIS cases treated by local excision, there was no difference in frequency of S100A7 expression between patients with recurrence of DCIS (n = 9) and those without (n = 36).

Conclusion

The findings reported here suggest that, although S100A7 may not be a marker for recurrence of DCIS, it is associated with poor prognostic markers in DCIS and may influence progression of breast carcinoma through its interaction with and influence on Jab1.
Appendix
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Literature
1.
Leygue E, Snell L, Hiller T, Dotzlaw H, Hole K, Murphy LC, Watson PH: Differential expression of psoriasin messenger RNA between in situ and invasive human breast carcinoma. Cancer Res. 1996, 56: 4606-4609.PubMed
2.
Enerback C, Porter DA, Seth P, Sgroi D, Gaudet J, Weremowicz S, Morton CC, Schnitt S, Pitts RL, Stampl J, Barnhart K, Polyak K: Psoriasin expression in mammary epithelial cells in vitro and in vivo. Cancer Res. 2002, 62: 43-47.PubMed
3.
Wulfkuhle JD, Sgroi DC, Krutzsch H, McLean K, McGarvey K, Knowlton M, Chen S, Shu H, Sahin A, Kurek R, Wallwiener D, Merino MJ, Petricoin EF, Zhao Y, Steeg PS: Proteomics of human breast ductal carcinoma in situ. Cancer Res. 2002, 62: 6740-6749.PubMed
4.
Alowami S, Qing G, Emberley E, Snell L, Watson PH: Psoriasin (S100A7) expression is altered during skin tumorigenesis. BMC Dermatol. 2003, 3: 1-10.1186/1471-5945-3-1.CrossRefPubMedPubMedCentral
5.
Claret FX, Hibi M, Dhut S, Toda T, Karin M: A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. Nature. 1996, 383: 453-457. 10.1038/383453a0.CrossRefPubMed
6.
7.
Emberley ED, Niu Y, Leygue E, Tomes L, Gietz RD, Murphy LC, Watson PH: Psoriasin interacts with Jab1 and influences breast cancer progression. Cancer Res. 2003, 63: 1954-1961.PubMed
8.
Tomoda K, Kubota Y, Kato J: Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1. Nature. 1999, 398: 160-165. 10.1038/18230.CrossRefPubMed
9.
Al-Haddad S, Zhang Z, Leygue E, Snell L, Huang A, Niu Y, Hiller-Hitchcock T, Hole K, Murphy LC, Watson PH: Psoriasin (S100A7) expression and invasive breast cancer. Am J Pathol. 1999, 155: 2057-2066.CrossRefPubMedPubMedCentral
10.
Watson PH, Snell L, Parisien M: The NCIC-Manitoba Breast Tumor Bank: a resource for applied cancer research. CMAJ. 1996, 155: 281-283.PubMedPubMedCentral
11.
Silverstein MJ, Lagios MD, Craig PH, Waisman JR, Lewinsky BS, Colburn WJ, Poller DN: A prognostic index for ductal carcinoma in situ of the breast. Cancer. 1996, 77: 2267-2274. 10.1002/(SICI)1097-0142(19960601)77:11<2267::AID-CNCR13>3.0.CO;2-V.CrossRefPubMed
12.
Emberley ED, Niu Y, Njue C, Kliewer EV, Murphy LC, Watson PH: Psoriasin (S100A7) expression is associated with poor outcome in estrogen receptor-negative invasive breast cancer. Clin Cancer Res. 2003, 9: 2627-2631.PubMed
13.
Schafer BW, Heizmann CW: The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends Biochem Sci. 1996, 21: 134-140. 10.1016/0968-0004(96)10020-7.CrossRefPubMed
14.
Pedrocchi M, Schafer BW, Mueller H, Eppenberger U, Heizmann CW: Expression of Ca2+-binding proteins of the S100 family in malignant human breast-cancer cell lines and biopsy samples. Int J Cancer. 1994, 57: 684-690.CrossRefPubMed
15.
Rudland PS, Platt-Higgins A, Renshaw C, West CR, Winstanley JH, Robertson L, Barraclough R: Prognostic significance of the metastasis-inducing protein S100A4 (p9Ka) in human breast cancer. Cancer Res. 2000, 60: 1595-1603.PubMed
16.
Albertazzi E, Cajone F, Leone BE, Naguib RN, Lakshmi MS, Sherbet GV: Expression of metastasis-associated genes h-mts1 (S100A4) and nm23 in carcinoma of breast is related to disease progression. DNA Cell Biol. 1998, 17: 335-342.CrossRefPubMed
17.
Davies BR, Barraclough R, Davies MP, Rudland PS: Production of the metastatic phenotype by DNA transfection in a rat mammary model. Cell Biol Int. 1993, 17: 871-879. 10.1006/cbir.1993.1150.CrossRefPubMed
18.
Madsen P, Rasmussen HH, Leffers H, Honore B, Dejgaard K, Olsen E, Kiil J, Walbum E, Andersen AH, Basse B, Lauridsen JB, Ratz GP, Celis A, Vandekerckhove J, Celis JE: Molecular cloning, occurrence, and expression of a novel partially secreted protein 'psoriasin' that is highly up-regulated in psoriatic skin. J Invest Dermatol. 1991, 97: 701-12. [AU: please provide surnames and initials for all authors.]CrossRefPubMed
19.
Hoffmann HJ, Olsen E, Etzerodt M, Madsen P, Thogersen HC, Kruse T, Celis JE: Psoriasin binds calcium and is upregulated by calcium to levels that resemble those observed in normal skin. J Invest Dermatol. 1994, 103: 370-375.CrossRefPubMed
20.
Jinquan T, Vorum H, Larsen CG, Madsen P, Rasmussen HH, Gesser B, Etzerodt M, Honore B, Celis JE, Thestrup-Pedersen K: Psoriasin: a novel chemotactic protein. J Invest Dermatol. 1996, 107: 5-10.CrossRefPubMed
21.
Watson PH, Leygue ER, Murphy LC: Psoriasin (S100A7). Int J Biochem Cell Biol. 1998, 30: 567-571. 10.1016/S1357-2725(97)00066-6.CrossRefPubMed
22.
Moog-Lutz C, Bouillet P, Regnier CH, Tomasetto C, Mattei MG, Chenard MP, Anglard P, Rio MC, Basset P: Comparative expression of the psoriasin (S100A7) and S100C genes in breast carcinoma and co-localization to human chromosome 1q21-q22. Int J Cancer. 1995, 63: 297-303.CrossRefPubMed
23.
Porter D, Lahti-Domenici J, Keshaviah A, Bae YK, Argani P, Marks J, Richardson A, Cooper A, Strausberg R, Riggins GJ, Schnitt S, Gabrielson E, Gelman R, Polyak K: Molecular markers in ductal carcinoma in situ of the breast. Mol Cancer Res. 2003, 1: 362-375.PubMed
24.
Fisher ER, Dignam J, Tan-Chiu E, Costantino J, Fisher B, Paik S, Wolmark N: Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) eight-year update of Protocol B-17: intraductal carcinoma. Cancer. 1999, 86: 429-438. 10.1002/(SICI)1097-0142(19990801)86:3<429::AID-CNCR11>3.0.CO;2-Y.CrossRefPubMed
25.
Porter DA, Krop IE, Nasser S, Sgroi D, Kaelin CM, Marks JR, Riggins G, Polyak K: A SAGE (serial analysis of gene expression) view of breast tumor progression. Cancer Res. 2001, 61: 5697-5702.PubMed
26.
Naumann M, Bech-Otschir D, Huang X, Ferrell K, Dubiel W: COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK. J Biol Chem. 1999, 274: 35297-35300. 10.1074/jbc.274.50.35297.CrossRefPubMed
27.
Bech-Otschir D, Seeger M, Dubiel W: The COP9 signalosome: at the interface between signal transduction and ubiquitin-dependent proteolysis. J Cell Sci. 2002, 115: 467-473.PubMed
28.
Bianchi E, Denti S, Granata A, Bossi G, Geginat J, Villa A, Rogge L, Pardi R: Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. Nature. 2000, 404: 617-621. 10.1038/35007098.CrossRefPubMed
29.
Chauchereau A, Georgiakaki M, Perrin-Wolff M, Milgrom E, Loosfelt H: JAB1 interacts with both the progesterone receptor and SRC-1. J Biol Chem. 2000, 275: 8540-8548. 10.1074/jbc.275.12.8540.CrossRefPubMed
30.
Kleemann R, Hausser A, Geiger G, Mischke R, Burger-Kentischer A, Flieger O, Johannes FJ, Roger T, Calandra T, Kapurniotu A, Grell M, Finkelmeier D, Brunner H, Bernhagen J: Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1. Nature. 2000, 408: 211-216. 10.1038/35041591.CrossRefPubMed
31.
Bae MK, Ahn MY, Jeong JW, Bae MH, Lee YM, Bae SK, Park JW, Kim KR, Kim KW: Jab1 interacts directly with HIF-1alpha and regulates its stability. J Biol Chem. 2002, 277: 9-12. 10.1074/jbc.C100442200.CrossRefPubMed
32.
Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, Engles J, Yochem R, Ratovitski E, Sidransky D, Jen J: Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1). Oncogene. 2002, 21: 3003-3010. 10.1038/sj.onc.1205390.CrossRefPubMed
33.
Tomoda K, Kubota Y, Arata Y, Mori S, Maeda M, Tanaka T, Yoshida M, Yoneda-Kato N, Kato JY: The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. J Biol Chem. 2002, 277: 2302-2310. 10.1074/jbc.M104431200.CrossRefPubMed
34.
Wan M, Cao X, Wu Y, Bai S, Wu L, Shi X, Wang N, Cao X: Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation. EMBO Rep. 2002, 3: 171-176. 10.1093/embo-reports/kvf024.CrossRefPubMedPubMedCentral
35.
Sui L, Dong Y, Ohno M, Watanabe Y, Sugimoto K, Tai Y, Tokuda M: Jab1 expression is associated with inverse expression of p27(kip1) and poor prognosis in epithelial ovarian tumors. Clin Cancer Res. 2001, 7: 4130-4135.PubMed
36.
Kouvaraki MA, Rassidakis GZ, Tian L, Kumar R, Kittas C, Claret FX: Jun activation domain-binding protein 1 expression in breast cancer inversely correlates with the cell cycle inhibitor p27(Kip1). Cancer Res. 2003, 63: 2977-2981.PubMed
37.
Rassidakis GZ, Claret FX, Lai R, Zhang Q, Sarris AH, McDonnell TJ, Medeiros LJ: Expression of p27(Kip1) and c-Jun activation binding protein 1 are inversely correlated in systemic anaplastic large cell lymphoma. Clin Cancer Res. 2003, 9: 1121-1128.PubMed
38.
Esteva FJ, Sahin AA, Rassidakis GZ, Yuan LX, Smith TL, Yang Y, Gilcrease MZ, Cristofanilli M, Nahta R, Pusztai L, Claret FX: Jun activation domain binding protein 1 expression is associated with low p27(Kip1)levels in node-negative breast cancer. Clin Cancer Res. 2003, 9: 5652-5659.PubMed
39.
Regitnig P, Moser R, Thalhammer M, Luschin-Ebengreuth G, Ploner F, Papadi H, Tsybrovskyy O, Lax SF: Microsatellite analysis of breast carcinoma and corresponding local recurrences. J Pathol. 2002, 198: 190-197. 10.1002/path.1193.CrossRefPubMed
40.
Lininger RA, Fujii H, Man YG, Gabrielson E, Tavassoli FA: Comparison of loss heterozygosity in primary and recurrent ductal carcinoma in situ of the breast. Mod Pathol. 1998, 11: 1151-1159.PubMed
Metadata
Title
S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situof the breast
Authors
Ethan D Emberley
Salem Alowami
Linda Snell
Leigh C Murphy
Peter H Watson
Publication date
01-08-2004
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 4/2004
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr791

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