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Breast Cancer Research
Published in: Breast Cancer Research 4/2004

Open Access 01-08-2004 | Research article

Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case–control study of African Americans and whites

Authors: Robert C Millikan, DVM, PhD, Jon Player, Allan René de Cotret, Patricia Moorman, Gary Pittman, Vani Vannappagari, Chiu-Kit J Tse, Temitope Keku

Published in: Breast Cancer Research | Issue 4/2004

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Abstract

Introduction

A polymorphism in the manganese superoxide dismutase (MnSOD) gene, Ala-9Val, has been examined in association with breast cancer risk in several epidemiologic studies. Results suggest that the Ala allele increases the risk of breast cancer and modifies the effects of environmental exposures that produce oxidative damage to DNA.

Methods

We examined the role of the MnSOD Ala-9Val polymorphism in a population-based case–control study of invasive and in situ breast cancer in North Carolina. Genotypes were evaluated for 2025 cases (760 African Americans and 1265 whites) and for 1812 controls (677 African Americans and 1135 whites).

Results

The odds ratio for MnSOD Ala/Ala versus any MnSOD Val genotypes was not elevated in African Americans (odds ratio = 0.9, 95% confidence interval = 0.7–1.2) or in whites (odds ratio = 1.0, 95% confidence interval = 0.8–1.2). Greater than additive joint effects were observed for the Ala/Ala genotype and smoking, radiation to the chest, and occupational exposure to ionizing radiation. Antagonism was observed between the Ala/Ala genotype and the use of nonsteroidal anti-inflammatory drugs.

Conclusions

The MnSOD genotype may contribute to an increased risk of breast cancer in the presence of specific environmental exposures. These results provide further evidence for the importance of reactive oxygen species and of oxidative DNA damage in the etiology of breast cancer.
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Metadata
Title
Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case–control study of African Americans and whites
Authors
Robert C Millikan, DVM, PhD
Jon Player
Allan René de Cotret
Patricia Moorman
Gary Pittman
Vani Vannappagari
Chiu-Kit J Tse
Temitope Keku
Publication date
01-08-2004
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 4/2004
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr786

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