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01-12-2002 | Commentary

Prolactin signaling and Stat5: going their own separate ways?

Authors: Cathrin Brisken, Ayyakkannu Ayyanan, Wolfgang Doppler

Published in: Breast Cancer Research | Issue 6/2002

Abstract

Miyoshi et al. compared the role of the prolactin receptor (PrlR) and its downstream mediator, the signal transducer and activator of transcription 5 (Stat5), in mammary epithelial cells in vivo by studying PrlR^-/- and Stat5ab^-/- mouse mammary epithelial transplants during pregnancy. At first glance, the two mutant epithelia appear to have similar defects in the differentiation of the alveolar epithelium. However, a closer examination by Miyoshi et al. revealed defects in the epithelial architecture of the smallest ducts of Stat5ab^-/- transplants not apparent in the PrlR^-/- transplants, suggesting that Stat5 is more than a simple mediator of PrlR action.

Nandi S: Endocrine control of mammary-gland development in the C3H/He Crgl mouse. J Natl Cancer Inst. 1958, 21: 1039-1063.PubMed

Lyons WR: Hormonal synergism in mammary growth. Proc R Soc Lond Ser B. 1958, 149: 303-325.CrossRef

Horseman ND: Prolactin. Endocrinology. Edited by: DeGroot LJ. 2001, WB Saunders, 1: 209-220. 4th

Ginsburg E, Vonderhaar B: Prolactin synthesis and secretion by human breast cancer cells. Cancer Res. 1995, 55: 2591-2595.PubMed

Gill S, Peston D, Vonderhaar BK, Shousha S: Expression of pro-lactin receptors in normal, benign, and malignant breast tissue: an immunohistological study. J Clin Pathol. 2001, 54: 956-960.CrossRefPubMedPubMedCentral

Goffin V, Kelly PN: The prolactin/growth hormone receptor family: structure/function relationships. J Mammary Gland Biol Neoplasia. 1997, 2: 7-17. 10.1023/A:1026313211704.CrossRefPubMed

Rui H, Kirken RA, Farrar WL: Activation of receptor-associated tyrosine kinase JAK2 by prolactin. J Biol Chem. 1994, 269: 5364-5368.PubMed

Groner B, Gouilleux F: Prolactin-mediated gene activation in mammary epithelial cells. Curr Opin Genet Dev. 1995, 5: 587-594. 10.1016/0959-437X(95)80027-1.CrossRefPubMed

Ihle JN, Stravapodis D, Parganas E, Thierfelder W, Feng J, Wang D, Teglund S: The roles of Jaks and Stats in cytokine signaling. Cancer J Sci Am. 1998, 4 (suppl 1): S84-S91.PubMed

10.

Liu X, Robinson GW, Gouilleux F, Groner B, Hennighausen L: Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc Natl Acad Sci USA. 1995, 92: 8831-8835.CrossRefPubMedPubMedCentral

11.

Ormandy CJ, Camus A, Barra J, Damotte D, Lucas B, Buteau H, Edery M, Brousse N, Babinet C, Binart N, Kelly PA: Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev. 1997, 11: 167-178.CrossRefPubMed

12.

Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, Wang D, Brown M, Bodner S, Grosveld G, Ihle JN: Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell. 1998, 93: 841-850. 10.1016/S0092-8674(00)81444-0.CrossRefPubMed

13.

Robinson GW, Hennighausen L, Johnson PF: Side-branching in the mammary gland: the progesterone-Wnt connection. Genes Dev. 2000, 14: 889-894.PubMed

14.

DeOme KB, Faulkin LJ, Bern HA, Blair PB: Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. Cancer Res. 1959, 19: 511-520.

15.

Brisken C, Kaur S, Chavarria T, Binart N, Sutherland R, Weinberg R, Kelly P, Ormandy C: Prolactin controls mammary gland development via direct and indirect mechanisms. Dev Biol. 1999, 210: 96-106. 10.1006/dbio.1999.9271.CrossRefPubMed

16.

Miyoshi K, Shillingford JM, Smith GH, Grimm SL, Wagner KU, Oka T, Rosen JM, Robinson GW, Hennighausen L: Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J Cell Biol. 2001, 155: 531-542. 10.1083/jcb.200107065.CrossRefPubMedPubMedCentral

17.

Brisken C, Heineman A, Chavarria T, Elenbaas B, Tan J, Dey S, McMahon J, McMahon A, Weinberg R: Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev. 2000, 14: 650-654.PubMedPubMedCentral

18.

Kiesling M, Woldman I, Moriggl R, Hofmann J, Marine J-C, Ihle JN, Beug H, Decker T: Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation. Genes Dev. 2000, 14: 232-244.

19.

Gallego MI, Binart N, Robinson GW, Okagaki R, Coschigano KT, Perry J, Kopchick JJ, Oka T, Kelly PA, Hennighausen L: Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effect. Dev Biol. 2001, 229: 163-175. 10.1006/dbio.2000.9961.CrossRefPubMed

20.

Jones FE, Welte T, Fu X-Y, Stern DF: ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation. J Cell Biol. 1999, 147: 77-88. 10.1083/jcb.147.1.77.CrossRefPubMedPubMedCentral

21.

Cacalano NA, Sanden D, Johnston JA: Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras. Nat Cell Biol. 2001, 3: 460-465. 10.1038/35074525.CrossRefPubMed

22.

Tonko-Geymayer S, Goupille O, Tonko M, Soratroi C, Yoshimura A, Streuli C, Ziemiecki A, Kofler R, Doppler W: Regulation and function of the cytokine-inducible SH-2 domain proteins, CIS and SOCS3, in mammary epithelial cells. Mol Endocrinol. 2002, 16: 1680-1695. 10.1210/me.16.7.1680.CrossRefPubMed

23.

Haslam SZ, Shyamala G: Effect of oestradiol on progesterone receptors in normal mammary glands and its relationship with lactation. Biochem J. 1979, 182: 127-131.CrossRefPubMedPubMedCentral

24.

Mizoguchi Y, Kim JY, Enami J, Sakai S: The regulation of the prolactin receptor gene expression in the mammary gland of early pregnant mouse. Endocr J. 1997, 44: 53-58.CrossRefPubMed

25.

Gibori G, Richards JS, Keyes PL: Synergistic effects of pro-lactin and estradiol in the luteotropic process in the pregnant rat: regulation of estradiol receptor by prolactin. Biol Reprod. 1979, 21: 419-423.CrossRefPubMed

26.

Telleria CM, Zhong L, Deb S, Srivastava RK, Park KS, Sugino N, Park-Sarge OK, Gibori G: Differential expression of the estrogen receptors alpha and beta in the rat corpus luteum of pregnancy: regulation by prolactin and placental lactogens. Endocrinology. 1998, 139: 2432-2442. 10.1210/en.139.5.2432.PubMed

27.

Edery M, Imagawa W, Larson L, Nandi S: Regulation of estrogen and progesterone receptor levels in mouse mammary epithelial cells grown in serum-free collagen gel cultures. Endocrinology. 1985, 116: 105-112.CrossRefPubMed

Title: Prolactin signaling and Stat5: going their own separate ways?
Authors: Cathrin Brisken
Ayyakkannu Ayyanan
Wolfgang Doppler
Publication date: 01-12-2002
Publisher: BioMed Central
Published in: Breast Cancer Research / Issue 6/2002
Electronic ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr543

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