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Breast Cancer Research
Published in: Breast Cancer Research 6/2002

01-12-2002 | Review

Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function

Authors: Emma Marshman, Charles H Streuli

Published in: Breast Cancer Research | Issue 6/2002

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Abstract

Insulin-like growth factor (IGF)-mediated proliferation and survival are essential for normal development in the mammary gland during puberty and pregnancy. IGFs interact with IGF-binding proteins and regulate their function. The present review focuses on the role of IGFs and IGF-binding proteins in the mammary gland and describes how modulation of their actions occurs by association with hormones, other growth factors and the extracellular matrix. The review will also highlight the involvement of the IGF axis in breast cancer.
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Metadata
Title
Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function
Authors
Emma Marshman
Charles H Streuli
Publication date
01-12-2002
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2002
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr535

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