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Open Access 01-10-2012 | Research article

Vascular endothelial growth factor receptor-1 mRNA overexpression in peripheral blood as a useful prognostic marker in breast cancer

Authors: Yoshimasa Kosaka, Akemi Kataoka, Hiroshi Yamaguchi, Hiroaki Ueo, Sayuri Akiyoshi, Norihiko Sengoku, Masaru Kuranami, Shinji Ohno, Masahiko Watanabe, Koshi Mimori, Masaki Mori

Published in: Breast Cancer Research | Issue 5/2012

Abstract

Introduction

Identification of useful markers associated with poor prognosis in breast cancer patients is critically needed. We previously showed that expression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood may be useful to predict distant metastasis in gastric cancer patients. However, expression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood of breast cancer patients has not yet been studied.

Methods

Real-time reverse transcriptase-PCR was used to analyze vascular endothelial growth factor receptor-1 mRNA expression status with respect to various clinical parameters in 515 patients with breast cancer and 25 controls.

Results

Expression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood was higher in breast cancer patients than in controls. Increased vascular endothelial growth factor receptor-1 mRNA expression was associated with large tumor size, lymph node metastasis and clinical stage. Patients with high vascular endothelial growth factor receptor-1 mRNA expression also experienced a poorer survival rate than those with low expression levels, including those patients with triple-negative type and luminal-HER2(-) type disease.

Conclusions

Expression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood may be useful for prediction of poor prognosis in breast cancer, especially in patients with triple-negative type and luminal-HER2(-) type disease.

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Title: Vascular endothelial growth factor receptor-1 mRNA overexpression in peripheral blood as a useful prognostic marker in breast cancer
Authors: Yoshimasa Kosaka
Akemi Kataoka
Hiroshi Yamaguchi
Hiroaki Ueo
Sayuri Akiyoshi
Norihiko Sengoku
Masaru Kuranami
Shinji Ohno
Masahiko Watanabe
Koshi Mimori
Masaki Mori
Publication date: 01-10-2012
Publisher: BioMed Central
Published in: Breast Cancer Research / Issue 5/2012
Electronic ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr3345

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