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Breast Cancer Research
Published in: Breast Cancer Research 6/2010

01-12-2010 | Review

Key signaling nodes in mammary gland development and cancer: β-catenin

Authors: Angela Incassati, Anupama Chandramouli, Rachel Eelkema, Pamela Cowin

Published in: Breast Cancer Research | Issue 6/2010

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Abstract

β-Catenin plays important roles in mammary development and tumorigenesis through its functions in cell adhesion, signal transduction and regulation of cell-context-specific gene expression. Studies in mice have highlighted the critical role of β-catenin signaling for stem cell biology at multiple stages of mammary development. Deregulated β-catenin signaling disturbs stem and progenitor cell dynamics and induces mammary tumors in mice. Recent data showing deregulated β-catenin signaling in metaplastic and basal-type tumors suggest a similar link to reactivated developmental pathways and human breast cancer. The present review will discuss β-catenin as a central transducer of numerous signaling pathways and its role in mammary development and breast cancer.
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Metadata
Title
Key signaling nodes in mammary gland development and cancer: β-catenin
Authors
Angela Incassati
Anupama Chandramouli
Rachel Eelkema
Pamela Cowin
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2010
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2723

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