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Breast Cancer Research
Published in: Breast Cancer Research 1/1999

01-12-1999 | Paper Report

ER and control of cyclin D1 expression

Author: Rob Clarke

Published in: Breast Cancer Research | Issue 1/1999

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Excerpt

Oestrogen receptor (ER) function can induce cyclin D1 expression leading to proliferation in human breast cancer cells (MCF-7). Recent studies showing that ER-positive epithelial cells in the human mammary gland are nonproliferative indicate that a direct mitogenic effect of oestrogen on mammary epithelial cells is gained during breast tumorigenesis. …
Literature
1.
Planas-Silva MD, Donaher JL, Weinberg RA: Functional activity of ectopically expressed estrogen receptor is not sufficient for estrogen-mediated cyclin D1 expression. Cancer Res. 1999, 59: 4788-4792.PubMed
Metadata
Title
ER and control of cyclin D1 expression
Author
Rob Clarke
Publication date
01-12-1999
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 1/1999
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr-1999-66624

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