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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2003

01-03-2003 | Review

Aggrecanases and cartilage matrix degradation

Authors: Hideaki Nagase, Masahide Kashiwagi

Published in: Arthritis Research & Therapy | Issue 2/2003

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Abstract

The loss of extracellular matrix macromolecules from the cartilage results in serious impairment of joint function. Metalloproteinases called 'aggrecanases' that cleave the Glu373–Ala374 bond of the aggrecan core protein play a key role in the early stages of cartilage destruction in rheumatoid arthritis and in osteoarthritis. Three members of the ADAMTS family of proteinases, ADAMTS-1, ADAMTS-4 and ADAMTS-5, have been identified as aggrecanases. Matrix metalloproteinases, which are also found in arthritic joints, cleave aggrecans, but at a distinct site from the aggrecanases (i.e. Asn341–Phe342). The present review discuss the enzymatic properties of the three known aggrecanases, the regulation of their activities, and their role in cartilage matrix breakdown during the development of arthritis in relation to the action of matrix metalloproteinases.
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Metadata
Title
Aggrecanases and cartilage matrix degradation
Authors
Hideaki Nagase
Masahide Kashiwagi
Publication date
01-03-2003
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2003
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar630

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