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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 3/2002

01-07-2002 | Review

Matrix metalloproteinases in arthritic disease

Authors: Gillian Murphy, Vera Knäuper, Susan Atkinson, George Butler, William English, Mike Hutton, Jan Stracke, Ian Clark

Published in: Arthritis Research & Therapy | Special Issue 3/2002

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Chapter summary

The role of matrix metalloproteinases in the degradative events invoked in the cartilage and bone of arthritic joints has long been appreciated and attempts at the development of proteinase inhibitors as potential therapeutic agents have been made. However, the spectrum of these enzymes orchestrating connective tissue turnover and general biology is much larger than anticipated. Biochemical studies of the individual members of the matrix metalloproteinase family are now underway, ultimately leading to a more detailed understanding of the function of their domain structures and to defining their specific role in cellular systems and the way that they are regulated. Coupled with a more comprehensive and detailed study of proteinase expression in different cells of joint tissues during the progress of arthritic diseases, it will be possible for the future development and application of highly specific proteinase inhibitors to be directed at specific key cellular events.
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Metadata
Title
Matrix metalloproteinases in arthritic disease
Authors
Gillian Murphy
Vera Knäuper
Susan Atkinson
George Butler
William English
Mike Hutton
Jan Stracke
Ian Clark
Publication date
01-07-2002
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 3/2002
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar572

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