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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2014

01-02-2014 | Editorial

Understanding IFNλ in rheumatoid arthritis

Authors: Rik A de Groen, Bi-Sheng Liu, André Boonstra

Published in: Arthritis Research & Therapy | Issue 1/2014

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Abstract

Unraveling the mechanisms underlying the inflammatory response in rheumatoid arthritis is crucial in order to better understand the disease and to develop novel therapeutic approaches. Although the effect of type I interferons on fibroblasts and in the context of rheumatoid arthritis has been described for some time, little is known on the effects of the type III interferons, also known as IFNλ. In a previous issue, Xu and colleagues demonstrate that one of the members of the IFNλ family, IFNλ1, enhances Toll-like receptor expression and consequently promotes the production of proinflammatory cytokines known to be involved in initiating and maintaining the inflammatory responses in rheumatoid arthritis.
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Literature
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Metadata
Title
Understanding IFNλ in rheumatoid arthritis
Authors
Rik A de Groen
Bi-Sheng Liu
André Boonstra
Publication date
01-02-2014
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2014
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar4445

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