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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

Cigarette smoke downregulates HDAC2 in rheumatoid arthritis synovial fibroblasts

Authors: Anna Engler, Astrid Jüngel, Christoph Kolling, Beat A Michel, Renate Gay, Steffen Gay, Caroline Ospelt

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

Cigarette smoking has been shown as major environmental risk factor for rheumatoid arthritis (RA). Epidemiological studies indicate an association of cigarette smoking with development of RA [1, 2], although molecular mechanisms remain unknown. The aim of this study is to analyze the influence of cigarette smoke on the gene expression regulated by histone deacetylases (HDACs) in RA synovial fibroblasts (RASF). …
Literature
1.
Bergstrom U, Jacobsson LT, Nilsson JA, Berglund G, Turesson C: Pulmonary dysfunction, smoking, socioeconomic status and the risk of developing rheumatoid arthritis. Rheumatology (Oxford). 2011, 50: 2005-2013. 10.1093/rheumatology/ker258.CrossRef
2.
Hutchinson D, Shepstone L, Moots R, Lear JT, Lynch MP: Heavy cigarette smoking is strongly associated with rheumatoid arthritis (RA), particularly in patients without a family history of RA. Ann Rheum Dis. 2001, 60: 223-227. 10.1136/ard.60.3.223.PubMedCentralCrossRefPubMed
Metadata
Title
Cigarette smoke downregulates HDAC2 in rheumatoid arthritis synovial fibroblasts
Authors
Anna Engler
Astrid Jüngel
Christoph Kolling
Beat A Michel
Renate Gay
Steffen Gay
Caroline Ospelt
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3612

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