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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2010

01-04-2010 | Review

Gout. Mechanisms of inflammation in gout

Authors: Nathalie Busso, Alexander So

Published in: Arthritis Research & Therapy | Issue 2/2010

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Abstract

An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1β release from leucocytes lies at the heart of a cascade of processes that involves multiple cytokines and mediators. The NLRP3 inflammasome appears to have a specific role in this regard, but the biochemical events leading to its activation are still not well understood. We review the known mechanisms that underlie the inflammatory process triggered by urate crystals and suggest areas that require further research.
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Metadata
Title
Gout. Mechanisms of inflammation in gout
Authors
Nathalie Busso
Alexander So
Publication date
01-04-2010
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2010
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2952

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