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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 3/2009

Open Access 01-06-2009 | Research article

Relationship of compartment-specific structural knee status at baseline with change in cartilage morphology: a prospective observational study using data from the osteoarthritis initiative

Authors: Felix Eckstein, Wolfgang Wirth, Martin I Hudelmaier, Susanne Maschek, Wolfgang Hitzl, Bradley T Wyman, Michael Nevitt, Marie-Pierre Hellio Le Graverand, David Hunter, the OA Initiative Investigator Group

Published in: Arthritis Research & Therapy | Issue 3/2009

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Abstract

Introduction

The aim was to investigate the relationship of cartilage loss (change in medial femorotibial cartilage thickness measured with magnetic resonance imaging (MRI)) with compartment-specific baseline radiographic findings and MRI cartilage morphometry features, and to identify which baseline features can be used for stratification of fast progressors.

Methods

An age and gender stratified subsample of the osteoarthritis (OA) initiative progression subcohort (79 women; 77 men; age 60.9 ± 9.9 years; body mass index (BMI) 30.3 ± 4.7) with symptomatic, radiographic OA in at least one knee was studied. Baseline fixed flexion radiographs were read centrally and adjudicated, and cartilage morphometry was performed at baseline and at one year follow-up from coronal FLASH 3 Tesla MR images of the right knee.

Results

Osteophyte status at baseline was not associated with medial cartilage loss. Knees with medial joint space narrowing tended to show higher rates of change than those without, but the relationship was not statistically significant. Knees with medial femoral subchondral bone sclerosis (radiography), medial denuded subchondral bone areas (MRI), and low cartilage thickness (MRI) at baseline displayed significantly higher cartilage loss than those without, both with and without adjusting for age, sex, and BMI. Participants with denuded subchondral bone showed a standardized response mean of up to -0.64 versus -0.33 for the entire subcohort.

Conclusions

The results indicate that radiographic and MRI cartilage morphometry features suggestive of advanced disease appear to be associated with greater cartilage loss. These features may be suited for selecting patients with a higher likelihood of fast progression in studies that attempt to demonstrate the cartilage-preserving effect of disease-modifying osteoarthritis drugs.
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Metadata
Title
Relationship of compartment-specific structural knee status at baseline with change in cartilage morphology: a prospective observational study using data from the osteoarthritis initiative
Authors
Felix Eckstein
Wolfgang Wirth
Martin I Hudelmaier
Susanne Maschek
Wolfgang Hitzl
Bradley T Wyman
Michael Nevitt
Marie-Pierre Hellio Le Graverand
David Hunter
the OA Initiative Investigator Group
Publication date
01-06-2009
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 3/2009
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2732

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