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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2009

01-04-2009 | Review

Progress in spondylarthritis. Mechanisms of new bone formation in spondyloarthritis

Authors: Rik JU Lories, Frank P Luyten, Kurt de Vlam

Published in: Arthritis Research & Therapy | Issue 2/2009

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Abstract

Targeted therapies that neutralize tumour necrosis factor are often able to control the signs and symptoms of spondyloarthritis. However, recent animal model data and clinical observations indicate that control of inflammation may not be sufficient to impede disease progression toward ankylosis in these patients. Bone morphogenetic proteins and WNTs (wingless-type like) are likely to play an important role in ankylosis and could be therapeutic targets. The relationship between inflammation and new bone formation is still unclear. This review summarizes progress made in our understanding of ankylosis and offers an alternative view of the relationship between inflammation and ankylosis.
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Metadata
Title
Progress in spondylarthritis. Mechanisms of new bone formation in spondyloarthritis
Authors
Rik JU Lories
Frank P Luyten
Kurt de Vlam
Publication date
01-04-2009
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2009
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2642

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