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01-10-2008 | Review

Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis

Authors: Stefan K Drexler, Philip L Kong, Jeremy Wales, Brian M Foxwell

Published in: Arthritis Research & Therapy | Issue 5/2008

Abstract

Rheumatoid arthritis is a multisystemic auto-inflammatory disease affecting up to 1% of the population and leading to the destruction of the joints. Evidence exists for the involvement of the innate as well as the adaptive immune systems in the pathology of the disease. The success of anti-tumour necrosis factor-α indicates the importance of pro-inflammatory mediators produced by innate immune cells in rheumatoid arthritis progression. Therefore, considerable efforts have been made in elucidating the signalling pathways leading to the expression of those mediators. This review will concentrate on the role of signalling pathways in innate immune cells in the context of rheumatoid arthritis.

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Title: Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis
Authors: Stefan K Drexler
Philip L Kong
Jeremy Wales
Brian M Foxwell
Publication date: 01-10-2008
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 5/2008
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar2481

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