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01-10-2008 | Review

Genetic studies in osteoporosis – the end of the beginning

Authors: Emma L Duncan, Matthew A Brown

Published in: Arthritis Research & Therapy | Issue 5/2008

Abstract

Osteoporosis and disorders of bone fragility are highly heritable, but despite much effort the identities of few of the genes involved has been established. Recent developments in genetics such as genome-wide association studies are revolutionizing research in this field, and it is likely that further contributions will be made through application of next-generation sequencing technologies, analysis of copy number variation polymorphisms, and high-throughput mouse mutagenesis programs. This article outlines what we know about osteoporosis genetics to date and the probable future directions of research in this field.

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Title: Genetic studies in osteoporosis – the end of the beginning
Authors: Emma L Duncan
Matthew A Brown
Publication date: 01-10-2008
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 5/2008
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar2479

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