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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 4/2006

01-08-2006 | Letter

Replication of association of the D-repeat polymorphism in asporin with osteoarthristis

Authors: Shiro Ikegawa, Shingo Kawamura, Atsushi Takahashi, Takahiro Nakamura, Naoyuki Kamatani

Published in: Arthritis Research & Therapy | Issue 4/2006

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Excerpt

Rodriguez-Lopez and colleagues [1] describe a replication study of our previous association between osteoarthritis (OA) and asporin [2]. The authors were unable to find this association in the Spanish population and question the association we found in the Japanese population. Their report also contains an interpretation of two previous papers on the same topic [3, 4] that differs from those of the original study authors. We have concerns about their interpretation of data and about the conclusions drawn. …
Literature
1.
Rodriguez-Lopez J, Pombo-Suarez M, Liz M, Gomez-Reino JJ, Gonzalez A: Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians. Arthritis Res Ther. 2006, 8: R55-10.1186/ar1920.PubMedCentralCrossRefPubMed
2.
Kizawa H, Kou I, Iida A, Sudo A, Miyamoto Y, Fukuda A, Mabuchi A, Kotani A, Kawakami A, Yamamoto S, et al: An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Nat Genet. 2005, 37: 138-144. 10.1038/ng1496.CrossRefPubMed
3.
Mustafa Z, Dowling B, Chapman K, Sinsheimer JS, Carr A, Loughlin J: Investigating the aspartic acid (D) repeat of asporin as a risk factor for osteoarthritis in a UK Caucasian population. Arthritis Rheum. 2005, 52: 3502-3506. 10.1002/art.21399.CrossRefPubMed
4.
Kaliakatsos M, Tzetis M, Kanavakis E, Fytili P, Chouliaras G, Karachalios T, Malizos K, Tsezou A: Asporin and knee osteoarthritis in patients of Greek origin. Osteoarthritis Cartilage. 2006, 14: 609-611. 10.1016/j.joca.2005.10.012.CrossRefPubMed
5.
Ioannidis JP, Ntzani EE, Trikalinos TA, Countopoulos-Ioannidis DG: Replication validity of genetic association studies. Nat Genet. 2001, 29: 306-309. 10.1038/ng749.CrossRefPubMed
6.
Metadata
Title
Replication of association of the D-repeat polymorphism in asporin with osteoarthristis
Authors
Shiro Ikegawa
Shingo Kawamura
Atsushi Takahashi
Takahiro Nakamura
Naoyuki Kamatani
Publication date
01-08-2006
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 4/2006
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1992

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