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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2006

01-07-2006 | Review

Interleukin-6 and rheumatic diseases

Author: Peter E Lipsky

Published in: Arthritis Research & Therapy | Special Issue 2/2006

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Abstract

IL-6 is a pleiotropic cytokine involved in both the initiation and the maintenance of the inflammatory and immunologic responses in certain autoimmune diseases. Blocking of these two complementary functions of IL-6 may confer additive, or even unique, benefits to the patient. The levels of both IL-6 and its soluble receptor (sIL-6Rα) are elevated to various degrees in many rheumatic diseases. IL-6 blockade has been shown to be beneficial both in experimental models and in human disease, and inhibition of IL-6 signaling with a molecule such as tocilizumab could prevent or reverse some of the complications typically associated with rheumatic diseases.
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Metadata
Title
Interleukin-6 and rheumatic diseases
Author
Peter E Lipsky
Publication date
01-07-2006
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 2/2006
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1918

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