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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2006

01-02-2006 | Commentary

The role of HIF-1α in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis

Authors: David Pfander, Bernd Swoboda, Thorsten Cramer

Published in: Arthritis Research & Therapy | Issue 1/2006

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Abstract

As a consequence of the avascular nature of cartilage the microenvironment in which chondrocytes must exist is characterized by hostile conditions, most prominently very low levels of oxygen (hypoxia). In recent years, a vast number of papers reporting on the role of hypoxia in cartilage development and disease has been published. It is well established today that the principal mediator of cellular adaptation to hypoxia, the transcription factor hypoxia inducible factor (HIF)-1, is of pivotal importance for survival and growth arrest of chondrocytes during cartilage development as well as energy generation and matrix synthesis of chondrocytes in healthy as well as osteoarthritic cartilage. With this commentary we aim to briefly discuss the recently published literature in this field.
Literature
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Metadata
Title
The role of HIF-1α in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis
Authors
David Pfander
Bernd Swoboda
Thorsten Cramer
Publication date
01-02-2006
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2006
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1894

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