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Published in:

01-02-2006 | Review

Epstein–Barr virus and rheumatoid arthritis: is there a link?

Authors: Karen H Costenbader, Elizabeth W Karlson

Published in: Arthritis Research & Therapy | Issue 1/2006

Abstract

Rheumatoid arthritis is a systemic autoimmune disease characterized by chronic, destructive, debilitating arthritis. Its etiology is unknown; it is presumed that environmental factors trigger development in the genetically predisposed. Epstein–Barr virus, a nearly ubiquitous virus in the human population, has generated great interest as a potential trigger. This virus stimulates polyclonal lymphocyte expansion and persists within B lymphocytes for the host's life, inhibited from reactivating by the immune response. In latent and replicating forms, it has immunomodulating actions that could play a role in the development of this autoimmune disease. The evidence linking Epstein–Barr virus and rheumatoid arthritis is reviewed.

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Title: Epstein–Barr virus and rheumatoid arthritis: is there a link?
Authors: Karen H Costenbader
Elizabeth W Karlson
Publication date: 01-02-2006
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 1/2006
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar1893

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