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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 4/2005

01-06-2005 | Review

ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis

Authors: Gavin C Jones, Graham P Riley

Published in: Arthritis Research & Therapy | Issue 4/2005

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Abstract

Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family are known to influence development, angiogenesis, coagulation and progression of arthritis. As proteinases their substrates include the von Willebrand factor precursor and extracellular matrix components such as procollagen, hyalectans (hyaluronan-binding proteoglycans including aggrecan), decorin, fibromodulin and cartilage oligomeric matrix protein. ADAMTS levels and activities are regulated at multiple levels through the control of gene expression, mRNA splicing, protein processing and inhibition by TIMP (tissue inhibitor of metalloproteinases). A recent screen of human cartilage has shown that multiple members of the ADAMTS family may be important in connective tissue homeostasis and pathology.
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Metadata
Title
ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis
Authors
Gavin C Jones
Graham P Riley
Publication date
01-06-2005
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 4/2005
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1783

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