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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 3/2005

01-03-2005 | Commentary

Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2

Authors: Annaleise V Sampey, Seetha Monrad, Leslie J Crofford

Published in: Arthritis Research & Therapy | Issue 3/2005

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Abstract

Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of mPGES-1 in the increased local production of PGE2 observed in inflammatory arthritis. The focus of this article is to review some recent advances in our understanding of mechanisms specific to the regulation of inducible mPGES-1 in inflammatory arthritis.
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Metadata
Title
Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2
Authors
Annaleise V Sampey
Seetha Monrad
Leslie J Crofford
Publication date
01-03-2005
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 3/2005
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1748

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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