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Journal of Diabetes & Metabolic Disorders
Published in: Journal of Diabetes & Metabolic Disorders 1/2013

Open Access 01-12-2013 | Review article

Dietary polyphenols as potential nutraceuticals in management of diabetes: a review

Authors: Zahra Bahadoran, Parvin Mirmiran, Fereidoun Azizi

Published in: Journal of Diabetes & Metabolic Disorders | Issue 1/2013

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Abstract

In recent years, there is growing evidence that plant-foods polyphenols, due to their biological properties, may be unique nutraceuticals and supplementary treatments for various aspects of type 2 diabetes mellitus. In this article we have reviewed the potential efficacies of polyphenols, including phenolic acids, flavonoids, stilbenes, lignans and polymeric lignans, on metabolic disorders and complications induced by diabetes. Based on several in vitro, animal models and some human studies, dietary plant polyphenols and polyphenol-rich products modulate carbohydrate and lipid metabolism, attenuate hyperglycemia, dyslipidemia and insulin resistance, improve adipose tissue metabolism, and alleviate oxidative stress and stress-sensitive signaling pathways and inflammatory processes. Polyphenolic compounds can also prevent the development of long-term diabetes complications including cardiovascular disease, neuropathy, nephropathy and retinopathy. Further investigations as human clinical studies are needed to obtain the optimum dose and duration of supplementation with polyphenolic compounds in diabetic patients.
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Metadata
Title
Dietary polyphenols as potential nutraceuticals in management of diabetes: a review
Authors
Zahra Bahadoran
Parvin Mirmiran
Fereidoun Azizi
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Journal of Diabetes & Metabolic Disorders / Issue 1/2013
Electronic ISSN: 2251-6581
DOI
https://doi.org/10.1186/2251-6581-12-43

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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