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Experimental Hematology & Oncology

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Open Access 01-12-2014 | Research

Survival and hospitalization among patients with acute myeloid leukemia treated with azacitidine or decitabine in a large managed care population: a real-world, retrospective, claims-based, comparative analysis

Authors: B Douglas Smith, Charles L Beach, Dalia Mahmoud, Laura Weber, Henry J Henk

Published in: Experimental Hematology & Oncology | Issue 1/2014

Abstract

Background

This study examined patient outcomes using real world data for acute myeloid leukemia (AML) patients initiating treatment.

Methods

A retrospective, administrative claims-based, comparative analysis was developed to study outcomes for AML patients initiating treatment with decitabine or azacitidine between January 2006 and June 2012.

Results

Treatment with azacitidine was associated with a longer median overall survival (10.1 versus 6.9 mos., p = 0.007) and a lower risk of hospitalization (HR 0.787, p = 0.02) compared to treatment with decitabine.

Conclusions

This analysis of the outcomes of real-world treatment of AML patients with demethylating agents suggests that azacitidine may result in clinically superior outcomes than decitabine.

Available only for authorised users

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Title: Survival and hospitalization among patients with acute myeloid leukemia treated with azacitidine or decitabine in a large managed care population: a real-world, retrospective, claims-based, comparative analysis
Authors: B Douglas Smith
Charles L Beach
Dalia Mahmoud
Laura Weber
Henry J Henk
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Experimental Hematology & Oncology / Issue 1/2014
Electronic ISSN: 2162-3619
DOI: https://doi.org/10.1186/2162-3619-3-10

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Abstract

Background

Methods

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