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Experimental Hematology & Oncology
Published in: Experimental Hematology & Oncology 1/2014

Open Access 01-12-2014 | Review

Ibrutinib for B cell malignancies

Authors: Aileen Novero, Pavan M Ravella, Yamei Chen, George Dous, Delong Liu

Published in: Experimental Hematology & Oncology | Issue 1/2014

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Abstract

Research over the role of Bruton’s agammaglobulinemia tyrosine kinase (BTK) in B-lymphocyte development, differentiation, signaling and survival has led to better understanding of the pathogenesis of B-cell malignancies. Down-regulation of BTK activity is an attractive novel strategy for treating patients with B-cell malignancies. Ibrutinib (PCI-32765), a potent inhibitor of BTK induces impressive responses in B-cell malignancies through irreversible bond with cysteine-481 in the active site of BTK (TH/SH1 domain) and inhibits BTK phosphorylation on Tyr223. This review discussed in details the role of BTK in B-cell signaling, molecular interactions between B cell lymphoma/leukemia cells and their microenvironment. Clinical trials of the novel BTK inhibitor, ibrutinib (PCI-32765), in B cell malignancies were summarized.
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Metadata
Title
Ibrutinib for B cell malignancies
Authors
Aileen Novero
Pavan M Ravella
Yamei Chen
George Dous
Delong Liu
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Experimental Hematology & Oncology / Issue 1/2014
Electronic ISSN: 2162-3619
DOI
https://doi.org/10.1186/2162-3619-3-4

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