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Published in: Experimental Hematology & Oncology 1/2012

Open Access 01-12-2012 | Short report

Outcome of match related allogeneic stem cell transplantation procedures performed from 2004 till 2011

Authors: Natasha Ali, Salman Naseem Adil, Mohammad Usman Shaikh, Munira Moosajee, Nehal Masood

Published in: Experimental Hematology & Oncology | Issue 1/2012

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Abstract

We present our initial experience of allogeneic stem cell transplant procedure performed between April 2004 and August 2011 for various haematological disorders. All patients with non-malignant and malignant haematological disorders with HLA matched donors were selected after pre-transplant workup. Ninety seven patients underwent the procedure. Most common indications for transplant were aplastic anaemia in n = 34 (35%), followed by β-Thalassemia major in n = 21 (21.6%) and chronic myeloid leukemia in n = 11 patients (11.3%). Primary graft failure present was present in 2.06%. Incidence of graft versus host disease (GvHD) in our patients was 34%. After median follow-up of five years the overall survival was 71.3% with a mean survival time of 51.2 ± 3.3 months.
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Literature
1.
go back to reference Joshua TV, Rizzo JD, Zhang MJ, Hari PN, Kurian S, Pasquini M, Majhail NS, Lee SJ, Horowitz MM: Access to hematopoietic stem cell transplantation: effect of race and sex. Cancer 2010,116(14):3469–3476. 10.1002/cncr.25297PubMedCentralPubMedCrossRef Joshua TV, Rizzo JD, Zhang MJ, Hari PN, Kurian S, Pasquini M, Majhail NS, Lee SJ, Horowitz MM: Access to hematopoietic stem cell transplantation: effect of race and sex. Cancer 2010,116(14):3469–3476. 10.1002/cncr.25297PubMedCentralPubMedCrossRef
2.
go back to reference Shamsi T, Hashmi K, Adil S, Ahmad P, Irfan M, Raza S, Masood N, Shaikh U, Satti T, Farzana T, et al.: The stem cell transplant program in Pakistan–the first decade. Bone Marrow Transplant 2008,42(Suppl 1):S114-S117.PubMedCrossRef Shamsi T, Hashmi K, Adil S, Ahmad P, Irfan M, Raza S, Masood N, Shaikh U, Satti T, Farzana T, et al.: The stem cell transplant program in Pakistan–the first decade. Bone Marrow Transplant 2008,42(Suppl 1):S114-S117.PubMedCrossRef
3.
go back to reference Baig SM, Azhar A, Hassan H, Baig JM, Kiyani A, Hameed U, Rabbi F, Bokhari H, Aslam M, Ud Din MA, et al.: Spectrum of beta-thalassemia mutations in various regions of Punjab and Islamabad, Pakistan: establishment of prenatal diagnosis. Haematologica 2006,91(3):ELT02.PubMed Baig SM, Azhar A, Hassan H, Baig JM, Kiyani A, Hameed U, Rabbi F, Bokhari H, Aslam M, Ud Din MA, et al.: Spectrum of beta-thalassemia mutations in various regions of Punjab and Islamabad, Pakistan: establishment of prenatal diagnosis. Haematologica 2006,91(3):ELT02.PubMed
4.
go back to reference Adil SN, Usman M: Acquired aplastic anemia and bone marrow transplantation. J Pak Med Assoc 2003,53(9):380–381.PubMed Adil SN, Usman M: Acquired aplastic anemia and bone marrow transplantation. J Pak Med Assoc 2003,53(9):380–381.PubMed
5.
go back to reference Sodani P, Gaziev D, Polchi P, Erer B, Giardini C, Angelucci E, Baronciani D, Andreani M, Manna M, Nesci S, et al.: New approach for bone marrow transplantation in patients with class 3 thalassemia aged younger than 17 years. Blood 2004,104(4):1201–1203. 10.1182/blood-2003-08-2800PubMedCrossRef Sodani P, Gaziev D, Polchi P, Erer B, Giardini C, Angelucci E, Baronciani D, Andreani M, Manna M, Nesci S, et al.: New approach for bone marrow transplantation in patients with class 3 thalassemia aged younger than 17 years. Blood 2004,104(4):1201–1203. 10.1182/blood-2003-08-2800PubMedCrossRef
6.
go back to reference Baldomero H, Gratwohl M, Gratwohl A, Tichelli A, Niederwieser D, Madrigal A, Frauendorfer K: The EBMT activity survey 2009: trends over the past 5 years. Bone Marrow Transplant ,46(4):485–501. Baldomero H, Gratwohl M, Gratwohl A, Tichelli A, Niederwieser D, Madrigal A, Frauendorfer K: The EBMT activity survey 2009: trends over the past 5 years. Bone Marrow Transplant ,46(4):485–501.
7.
go back to reference Ahmed SO, Ghavamzadeh A, Zaidi SZ, Baldomero H, Pasquini MC, Hussain F, Alimoghaddam K, Almohareb F, Ayas M, Hamidieh A, et al.: Trends of hematopoietic stem cell transplantation in the Eastern Mediterranean region, 1984–2007. Biol Blood Marrow Transplant 2011,17(9):1352–1361. 10.1016/j.bbmt.2011.01.019PubMedCentralPubMedCrossRef Ahmed SO, Ghavamzadeh A, Zaidi SZ, Baldomero H, Pasquini MC, Hussain F, Alimoghaddam K, Almohareb F, Ayas M, Hamidieh A, et al.: Trends of hematopoietic stem cell transplantation in the Eastern Mediterranean region, 1984–2007. Biol Blood Marrow Transplant 2011,17(9):1352–1361. 10.1016/j.bbmt.2011.01.019PubMedCentralPubMedCrossRef
8.
go back to reference Ullah K, Ahmed P, Raza S, Satti T, Nisa Q, Mirza S, Akhtar F, Kamal MK, Akhtar FM: Allogeneic stem cell transplantation in hematological disorders: single center experience from Pakistan. Transplant Proc 2007,39(10):3347–3357. 10.1016/j.transproceed.2007.08.099PubMedCrossRef Ullah K, Ahmed P, Raza S, Satti T, Nisa Q, Mirza S, Akhtar F, Kamal MK, Akhtar FM: Allogeneic stem cell transplantation in hematological disorders: single center experience from Pakistan. Transplant Proc 2007,39(10):3347–3357. 10.1016/j.transproceed.2007.08.099PubMedCrossRef
9.
go back to reference Khan SN, Riazuddin S: Molecular characterization of beta-thalassemia in Pakistan. Hemoglobin 1998,22(4):333–345. 10.3109/03630269809071528PubMedCrossRef Khan SN, Riazuddin S: Molecular characterization of beta-thalassemia in Pakistan. Hemoglobin 1998,22(4):333–345. 10.3109/03630269809071528PubMedCrossRef
10.
go back to reference Champlin RE, Schmitz N, Horowitz MM, Chapuis B, Chopra R, Cornelissen JJ, Gale RP, Goldman JM, Loberiza FR, Hertenstein B, et al.: 2000. Blood 2000,95(12):3702–3709.PubMed Champlin RE, Schmitz N, Horowitz MM, Chapuis B, Chopra R, Cornelissen JJ, Gale RP, Goldman JM, Loberiza FR, Hertenstein B, et al.: 2000. Blood 2000,95(12):3702–3709.PubMed
11.
go back to reference McCann SR, Bacigalupo A, Gluckman E, Hinterberger W, Hows J, Ljungman P, Marin P, Nissen C, Van't Veer Kerthof E, Raghavachar A, et al.: Graft rejection and second bone marrow transplants for acquired aplastic anaemia: a report from the Aplastic Anaemia Working Party of the European Bone Marrow Transplant Group. Bone Marrow Transplant 1994,13(3):233–237.PubMed McCann SR, Bacigalupo A, Gluckman E, Hinterberger W, Hows J, Ljungman P, Marin P, Nissen C, Van't Veer Kerthof E, Raghavachar A, et al.: Graft rejection and second bone marrow transplants for acquired aplastic anaemia: a report from the Aplastic Anaemia Working Party of the European Bone Marrow Transplant Group. Bone Marrow Transplant 1994,13(3):233–237.PubMed
12.
go back to reference Schriber J, Agovi MA, Ho V, Ballen KK, Bacigalupo A, Lazarus HM, Bredeson CN, Gupta V, Maziarz RT, Hale GA, et al.: Second unrelated donor hematopoietic cell transplantation for primary graft failure. Biol Blood Marrow Transplant 2010,16(8):1099–1106. 10.1016/j.bbmt.2010.02.013PubMedCentralPubMedCrossRef Schriber J, Agovi MA, Ho V, Ballen KK, Bacigalupo A, Lazarus HM, Bredeson CN, Gupta V, Maziarz RT, Hale GA, et al.: Second unrelated donor hematopoietic cell transplantation for primary graft failure. Biol Blood Marrow Transplant 2010,16(8):1099–1106. 10.1016/j.bbmt.2010.02.013PubMedCentralPubMedCrossRef
13.
go back to reference Bleakley M, Riddell SR: Molecules and mechanisms of the graft-versus-leukaemia effect. Nat Rev Cancer 2004,4(5):371–380. 10.1038/nrc1365PubMedCrossRef Bleakley M, Riddell SR: Molecules and mechanisms of the graft-versus-leukaemia effect. Nat Rev Cancer 2004,4(5):371–380. 10.1038/nrc1365PubMedCrossRef
14.
go back to reference Collin BA, Leather HL, Wingard JR, Ramphal R: Evolution, incidence, and susceptibility of bacterial bloodstream isolates from 519 bone marrow transplant patients. Clin Infect Dis 2001,33(7):947–953. 10.1086/322604PubMedCrossRef Collin BA, Leather HL, Wingard JR, Ramphal R: Evolution, incidence, and susceptibility of bacterial bloodstream isolates from 519 bone marrow transplant patients. Clin Infect Dis 2001,33(7):947–953. 10.1086/322604PubMedCrossRef
15.
go back to reference Lucarelli G, Andreani M, Angelucci E: The cure of the thalassemia with bone marrow transplantation. Bone Marrow Transplant 2001,28(Suppl 1):S11-S13.PubMedCrossRef Lucarelli G, Andreani M, Angelucci E: The cure of the thalassemia with bone marrow transplantation. Bone Marrow Transplant 2001,28(Suppl 1):S11-S13.PubMedCrossRef
16.
go back to reference Wang W, Wang X, Xu X, Lin G: Diagnosis and treatment of acquired aplastic anaemia in adults: 142 cases from a multicentre, prospective cohort study in shanghai, china. J Int Med Res 2011,39(5):1994–2005.PubMedCrossRef Wang W, Wang X, Xu X, Lin G: Diagnosis and treatment of acquired aplastic anaemia in adults: 142 cases from a multicentre, prospective cohort study in shanghai, china. J Int Med Res 2011,39(5):1994–2005.PubMedCrossRef
17.
go back to reference Eapen M, Le Rademacher J, Antin JH, Champlin RE, Carreras J, Fay J, Passweg JR, Tolar J, Horowitz MM, Marsh JC, et al.: Effect of stem cell source on outcomes after unrelated donor transplantation in severe aplastic anemia. Blood 2011,118(9):2618–2621. 10.1182/blood-2011-05-354001PubMedCentralPubMedCrossRef Eapen M, Le Rademacher J, Antin JH, Champlin RE, Carreras J, Fay J, Passweg JR, Tolar J, Horowitz MM, Marsh JC, et al.: Effect of stem cell source on outcomes after unrelated donor transplantation in severe aplastic anemia. Blood 2011,118(9):2618–2621. 10.1182/blood-2011-05-354001PubMedCentralPubMedCrossRef
18.
go back to reference Chen Y, Xu Y, Zhu Y, Fu G, Liu Y, Peng J, Fu B, He Q, Wu D, Li X, et al.: [Clinical analysis of 104 patients with hematological malignancy after allogeneic hemotopoietic stem cell transplantation]. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2011,36(9):859–864.PubMed Chen Y, Xu Y, Zhu Y, Fu G, Liu Y, Peng J, Fu B, He Q, Wu D, Li X, et al.: [Clinical analysis of 104 patients with hematological malignancy after allogeneic hemotopoietic stem cell transplantation]. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2011,36(9):859–864.PubMed
19.
go back to reference Yanada M, Matsuo K, Suzuki T, Naoe T: Allogeneic hematopoietic stem cell transplantation as part of postremission therapy improves survival for adult patients with high-risk acute lymphoblastic leukemia: a metaanalysis. Cancer 2006,106(12):2657–2663. 10.1002/cncr.21932PubMedCrossRef Yanada M, Matsuo K, Suzuki T, Naoe T: Allogeneic hematopoietic stem cell transplantation as part of postremission therapy improves survival for adult patients with high-risk acute lymphoblastic leukemia: a metaanalysis. Cancer 2006,106(12):2657–2663. 10.1002/cncr.21932PubMedCrossRef
20.
go back to reference Hunault M, Harousseau JL, Delain M, Truchan-Graczyk M, Cahn JY, Witz F, Lamy T, Pignon B, Jouet JP, Garidi R, et al.: Better outcome of adult acute lymphoblastic leukemia after early genoidentical allogeneic bone marrow transplantation (BMT) than after late high-dose therapy and autologous BMT: a GOELAMS trial. Blood 2004,104(10):3028–3037. 10.1182/blood-2003-10-3560PubMedCrossRef Hunault M, Harousseau JL, Delain M, Truchan-Graczyk M, Cahn JY, Witz F, Lamy T, Pignon B, Jouet JP, Garidi R, et al.: Better outcome of adult acute lymphoblastic leukemia after early genoidentical allogeneic bone marrow transplantation (BMT) than after late high-dose therapy and autologous BMT: a GOELAMS trial. Blood 2004,104(10):3028–3037. 10.1182/blood-2003-10-3560PubMedCrossRef
21.
go back to reference Baccarani M, Cortes J, Pane F, Niederwieser D, Saglio G, Apperley J, Cervantes F, Deininger M, Gratwohl A, Guilhot F, et al.: Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol 2009,27(35):6041–6051. 10.1200/JCO.2009.25.0779PubMedCrossRef Baccarani M, Cortes J, Pane F, Niederwieser D, Saglio G, Apperley J, Cervantes F, Deininger M, Gratwohl A, Guilhot F, et al.: Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol 2009,27(35):6041–6051. 10.1200/JCO.2009.25.0779PubMedCrossRef
22.
go back to reference Boehm A, Walcherberger B, Sperr WR, Wohrer S, Dieckmann K, Rosenmayr A, Pernicka E, Fischer G, Worel N, Mitterbauer G, et al.: Improved outcome in patients with chronic myelogenous leukemia after allogeneic hematopoietic stem cell transplantation over the past 25 years: a single-center experience. Biol Blood Marrow Transplant 2011,17(1):133–140. 10.1016/j.bbmt.2010.06.019PubMedCrossRef Boehm A, Walcherberger B, Sperr WR, Wohrer S, Dieckmann K, Rosenmayr A, Pernicka E, Fischer G, Worel N, Mitterbauer G, et al.: Improved outcome in patients with chronic myelogenous leukemia after allogeneic hematopoietic stem cell transplantation over the past 25 years: a single-center experience. Biol Blood Marrow Transplant 2011,17(1):133–140. 10.1016/j.bbmt.2010.06.019PubMedCrossRef
Metadata
Title
Outcome of match related allogeneic stem cell transplantation procedures performed from 2004 till 2011
Authors
Natasha Ali
Salman Naseem Adil
Mohammad Usman Shaikh
Munira Moosajee
Nehal Masood
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Experimental Hematology & Oncology / Issue 1/2012
Electronic ISSN: 2162-3619
DOI
https://doi.org/10.1186/2162-3619-1-13

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