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Published in: Experimental Hematology & Oncology 1/2012

Open Access 01-12-2012 | Short report

Numerical analysis of airflow alteration in central airways following tracheobronchial stent placement

Authors: Chien-Yi Ho, Hsiu-Mei Liao, Chih-Yen Tu, Chih-Yang Huang, Chuen-Ming Shih, Min-Ying Lydia Su, Jeon-Hor Chen, Tzu-Ching Shih

Published in: Experimental Hematology & Oncology | Issue 1/2012

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Abstract

The computational fluid dynamics method, which provides an estimation of the pressure drop in the airway before and after the stent implantation, is proposed in this study. This method is based on the finite volume model. The pressure field was solved by the Navier-Stokes equations. The proposed methodology was evaluated in seven health people (control group) and in fourteen patients who were assigned in two groups, in which one was tracheal stenosis and the other was bronchial stenosis. The results showed that the pressure drop after tracheal stent implantation became significantly smaller. For bronchial stent implantation cases, the airway resistance improved insignificantly.
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Literature
1.
go back to reference Brunings W, Albrecht W: Direkte Endoskopie der Luft und Speisewege. 1st edition. Ferdinand Enke Verlagsbuchhandlung, Stuttgart; 1915:134–8. Brunings W, Albrecht W: Direkte Endoskopie der Luft und Speisewege. 1st edition. Ferdinand Enke Verlagsbuchhandlung, Stuttgart; 1915:134–8.
2.
3.
go back to reference Vergnon JM, Costes F, Bayon MC, Emonot A: Efficacy of tracheal and bronchial stent placement on respiratory functional tests. Chest 1995, 107: 741–6. 10.1378/chest.107.3.741PubMedCrossRef Vergnon JM, Costes F, Bayon MC, Emonot A: Efficacy of tracheal and bronchial stent placement on respiratory functional tests. Chest 1995, 107: 741–6. 10.1378/chest.107.3.741PubMedCrossRef
4.
go back to reference Hauck RW, Romer W, Schulz C, Lembeck RM, Schomig A, Schwaiger M: Ventilation perfusion scintigraphy and lung function testing to assess metal stent efficacy. J Nucl Med 1997, 38: 1584–9.PubMed Hauck RW, Romer W, Schulz C, Lembeck RM, Schomig A, Schwaiger M: Ventilation perfusion scintigraphy and lung function testing to assess metal stent efficacy. J Nucl Med 1997, 38: 1584–9.PubMed
5.
go back to reference Gotway MB, Golden JA, LaBerge JM, et al.: Benign tracheobronchial stenoses: changes in short-term and long-term pulmonary function testing after expandable metallic stent placement. J Comput Assist Tomogr 2002, 26: 564–72. 10.1097/00004728-200207000-00016PubMedCrossRef Gotway MB, Golden JA, LaBerge JM, et al.: Benign tracheobronchial stenoses: changes in short-term and long-term pulmonary function testing after expandable metallic stent placement. J Comput Assist Tomogr 2002, 26: 564–72. 10.1097/00004728-200207000-00016PubMedCrossRef
6.
go back to reference Yerushalmi R, Fenig E, Shitrit D, et al.: Endobronchial stent for malignant airway obstructions. Isr Med Assoc J 2006, 8: 615–7.PubMed Yerushalmi R, Fenig E, Shitrit D, et al.: Endobronchial stent for malignant airway obstructions. Isr Med Assoc J 2006, 8: 615–7.PubMed
7.
go back to reference Chin CS, Litle V, Yun J, Weiser T, Swanson SJ: Airway stents. Ann Thorac Surg 2008, 85: S792–6. 10.1016/j.athoracsur.2007.11.051PubMedCrossRef Chin CS, Litle V, Yun J, Weiser T, Swanson SJ: Airway stents. Ann Thorac Surg 2008, 85: S792–6. 10.1016/j.athoracsur.2007.11.051PubMedCrossRef
8.
go back to reference Merrot O, Buiret G, Gleizal A, Poupart M, Pignat JC: Management of tracheobronchial stenoses with endoprostheses: experience with 103 patients and 11 models. Laryngoscope 2008, 118: 403–7. 10.1097/MLG.0b013e31815d8e79PubMedCrossRef Merrot O, Buiret G, Gleizal A, Poupart M, Pignat JC: Management of tracheobronchial stenoses with endoprostheses: experience with 103 patients and 11 models. Laryngoscope 2008, 118: 403–7. 10.1097/MLG.0b013e31815d8e79PubMedCrossRef
9.
go back to reference Pang YK, Liam CK, Leow CH, Shyamala P, Zal AR: Tracheobronchial stenting is safe and effective in relieving upper airway obstruction. Med J Malaysia 2006, 61: 147–50.PubMed Pang YK, Liam CK, Leow CH, Shyamala P, Zal AR: Tracheobronchial stenting is safe and effective in relieving upper airway obstruction. Med J Malaysia 2006, 61: 147–50.PubMed
10.
go back to reference Terra RM, Minamoto H, Tedde ML, Almeida JL, Jatene FB: Self-expanding stent made of polyester mesh with silicon coating (Polyflex) in the treatment of inoperable tracheal stenoses. J Bras Pneumol 2007, 33: 241–7. 10.1590/S1806-37132007000300003PubMedCrossRef Terra RM, Minamoto H, Tedde ML, Almeida JL, Jatene FB: Self-expanding stent made of polyester mesh with silicon coating (Polyflex) in the treatment of inoperable tracheal stenoses. J Bras Pneumol 2007, 33: 241–7. 10.1590/S1806-37132007000300003PubMedCrossRef
11.
go back to reference Hauck RW, Lembeck RM, Emslander HP, Schomig A: Implantation of Accuflex and Strecker stents in malignant bronchial stenoses by flexible bronchoscopy. Chest 1997, 112: 134–44. 10.1378/chest.112.1.134PubMedCrossRef Hauck RW, Lembeck RM, Emslander HP, Schomig A: Implantation of Accuflex and Strecker stents in malignant bronchial stenoses by flexible bronchoscopy. Chest 1997, 112: 134–44. 10.1378/chest.112.1.134PubMedCrossRef
12.
go back to reference Lemaire A, Burfeind WR, Toloza E, et al.: Outcomes of tracheobronchial stents in patients with malignant airway disease. Ann Thorac Surg 2005, 80: 434–7. discussion 7–8 10.1016/j.athoracsur.2005.02.071PubMedCrossRef Lemaire A, Burfeind WR, Toloza E, et al.: Outcomes of tracheobronchial stents in patients with malignant airway disease. Ann Thorac Surg 2005, 80: 434–7. discussion 7–8 10.1016/j.athoracsur.2005.02.071PubMedCrossRef
13.
go back to reference Matsuda N, Matsumoto S, Nishimura T, Wakamatsu H, Kunihiro M, Sakabe T: Perioperative management for placement of tracheobronchial stents. J Anesth 2006, 20: 113–7. 10.1007/s00540-005-0379-0PubMedCrossRef Matsuda N, Matsumoto S, Nishimura T, Wakamatsu H, Kunihiro M, Sakabe T: Perioperative management for placement of tracheobronchial stents. J Anesth 2006, 20: 113–7. 10.1007/s00540-005-0379-0PubMedCrossRef
14.
go back to reference Thornton RH, Gordon RL, Kerlan RK, et al.: Outcomes of tracheobronchial stent placement for benign disease. Radiology 2006, 240: 273–82. 10.1148/radiol.2401042169PubMedCrossRef Thornton RH, Gordon RL, Kerlan RK, et al.: Outcomes of tracheobronchial stent placement for benign disease. Radiology 2006, 240: 273–82. 10.1148/radiol.2401042169PubMedCrossRef
15.
go back to reference Makris D, Marquette CH: Tracheobronchial stenting and central airway replacement. Curr Opin Pulm Med 2007, 13: 278–83. 10.1097/MCP.0b013e32816b5c3bPubMedCrossRef Makris D, Marquette CH: Tracheobronchial stenting and central airway replacement. Curr Opin Pulm Med 2007, 13: 278–83. 10.1097/MCP.0b013e32816b5c3bPubMedCrossRef
16.
go back to reference Allen GM, Shortall BP, Gemci T, Corcoran TE, Chigier NA: Computational simulations of airflow in an in vitro model of the pediatric upper airways. J Biomech Eng 2004, 126: 604–13. 10.1115/1.1800554PubMedCrossRef Allen GM, Shortall BP, Gemci T, Corcoran TE, Chigier NA: Computational simulations of airflow in an in vitro model of the pediatric upper airways. J Biomech Eng 2004, 126: 604–13. 10.1115/1.1800554PubMedCrossRef
17.
go back to reference van Ertbruggen C, Hirsch C, Paiva M: Anatomically based three-dimensional model of airways to simulate flow and particle transport using computational fluid dynamics. J Appl Physiol 2005, 98: 970–80.PubMedCrossRef van Ertbruggen C, Hirsch C, Paiva M: Anatomically based three-dimensional model of airways to simulate flow and particle transport using computational fluid dynamics. J Appl Physiol 2005, 98: 970–80.PubMedCrossRef
18.
go back to reference Xu C, Sin S, McDonough JM, et al.: Computational fluid dynamics modeling of the upper airway of children with obstructive sleep apnea syndrome in steady flow. J Biomech 2006, 39: 2043–54. 10.1016/j.jbiomech.2005.06.021PubMedCrossRef Xu C, Sin S, McDonough JM, et al.: Computational fluid dynamics modeling of the upper airway of children with obstructive sleep apnea syndrome in steady flow. J Biomech 2006, 39: 2043–54. 10.1016/j.jbiomech.2005.06.021PubMedCrossRef
19.
go back to reference Yang XL, Liu Y, So RM, Yang JM: The effect of inlet velocity profile on the bifurcation COPD airway flow. Comput Biol Med 2006, 36: 181–94. 10.1016/j.compbiomed.2004.11.002PubMedCrossRef Yang XL, Liu Y, So RM, Yang JM: The effect of inlet velocity profile on the bifurcation COPD airway flow. Comput Biol Med 2006, 36: 181–94. 10.1016/j.compbiomed.2004.11.002PubMedCrossRef
20.
go back to reference Brouns M, Jayaraju ST, Lacor C, et al.: Tracheal stenosis: a flow dynamics study. J Appl Physiol 2007, 102: 1178–84.PubMedCrossRef Brouns M, Jayaraju ST, Lacor C, et al.: Tracheal stenosis: a flow dynamics study. J Appl Physiol 2007, 102: 1178–84.PubMedCrossRef
21.
go back to reference Liu Y, So RM, Zhang CH: Modeling the bifurcating flow in an asymmetric human lung airway. J Biomech 2003, 36: 951–9. 10.1016/S0021-9290(03)00064-2PubMedCrossRef Liu Y, So RM, Zhang CH: Modeling the bifurcating flow in an asymmetric human lung airway. J Biomech 2003, 36: 951–9. 10.1016/S0021-9290(03)00064-2PubMedCrossRef
22.
go back to reference Kabilan S, Lin CL, Hoffman EA: Characteristics of airflow in a CT-based ovine lung: a numerical study. J Appl Physiol 2007, 102: 1469–82.PubMedCrossRef Kabilan S, Lin CL, Hoffman EA: Characteristics of airflow in a CT-based ovine lung: a numerical study. J Appl Physiol 2007, 102: 1469–82.PubMedCrossRef
23.
go back to reference Chen MC, Lu PC, Chen JS, Hwang NH: Computational hemodynamics of an implanted coronary stent based on three-dimensional cine angiography reconstruction. ASAIO J 2005, 51: 313–20. 10.1097/01.mat.0000169117.07070.fbPubMedCrossRef Chen MC, Lu PC, Chen JS, Hwang NH: Computational hemodynamics of an implanted coronary stent based on three-dimensional cine angiography reconstruction. ASAIO J 2005, 51: 313–20. 10.1097/01.mat.0000169117.07070.fbPubMedCrossRef
24.
go back to reference Walser EM: Stent placement for tracheobronchial disease. Eur J Radiol 2005, 55: 321–30. 10.1016/j.ejrad.2005.03.005PubMedCrossRef Walser EM: Stent placement for tracheobronchial disease. Eur J Radiol 2005, 55: 321–30. 10.1016/j.ejrad.2005.03.005PubMedCrossRef
25.
go back to reference Simoff MJ: Endobronchial management of advanced lung cancer. Cancer Control 2001, 8: 337–43.PubMed Simoff MJ: Endobronchial management of advanced lung cancer. Cancer Control 2001, 8: 337–43.PubMed
26.
go back to reference Stephens KE Jr, Wood DE: Bronchoscopic management of central airway obstruction. J Thorac Cardiovasc Surg 2000, 119: 289–96. 10.1016/S0022-5223(00)70184-XPubMedCrossRef Stephens KE Jr, Wood DE: Bronchoscopic management of central airway obstruction. J Thorac Cardiovasc Surg 2000, 119: 289–96. 10.1016/S0022-5223(00)70184-XPubMedCrossRef
27.
go back to reference Luo HY, Liu Y: Modeling the bifurcating flow in a CT-scanned human lung airway. J Biomech 2008, 41: 2681–8. 10.1016/j.jbiomech.2008.06.018PubMedCrossRef Luo HY, Liu Y: Modeling the bifurcating flow in a CT-scanned human lung airway. J Biomech 2008, 41: 2681–8. 10.1016/j.jbiomech.2008.06.018PubMedCrossRef
28.
go back to reference Miyazawa T, Miyazu Y, Iwamoto Y, et al.: Stenting at the flow-limiting segment in tracheobronchial stenosis due to lung cancer. Am J Respir Crit Care Med 2004, 169: 1096–102. 10.1164/rccm.200311-1784OCPubMedCrossRef Miyazawa T, Miyazu Y, Iwamoto Y, et al.: Stenting at the flow-limiting segment in tracheobronchial stenosis due to lung cancer. Am J Respir Crit Care Med 2004, 169: 1096–102. 10.1164/rccm.200311-1784OCPubMedCrossRef
Metadata
Title
Numerical analysis of airflow alteration in central airways following tracheobronchial stent placement
Authors
Chien-Yi Ho
Hsiu-Mei Liao
Chih-Yen Tu
Chih-Yang Huang
Chuen-Ming Shih
Min-Ying Lydia Su
Jeon-Hor Chen
Tzu-Ching Shih
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Experimental Hematology & Oncology / Issue 1/2012
Electronic ISSN: 2162-3619
DOI
https://doi.org/10.1186/2162-3619-1-23

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