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Multidisciplinary Respiratory Medicine

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Open Access 01-12-2014 | Short report

Diagnostic delay of pulmonary nontuberculous mycobacterial infection in China

Authors: Hui Jing, Wanming Tan, Yunfeng Deng, Dachuan Gao, Liang Li, Zhiming Lu, Edward A Graviss, Xin Ma

Published in: Multidisciplinary Respiratory Medicine | Issue 1/2014

Abstract

Background

Nontuberculous mycobacteria (NTM) infection is an emerging, but neglected public health concern in China.

Findings

To investigate diagnostic delay of NTM diseases in China, we analyzed 91 patients with pulmonary NTM infection in ShandongProvince. The median diagnostic delay time of the analyzed patients was 84 days, which was significantly associated with rural inhabitance (135 days vs. 73 days of urban inhabitance, p < 0.01) and lower level of first visiting hospitals/clinics (70 and 82 days of tertiary and secondary hospitals/clinics respectively vs. 120 days of primary hospitals/clinics, p < 0.05). M. farcinogenes was isolated from a 79-year-old male patient, which is the first report of pulmonary infection in humans.

Conclusions

Our results indicate a significant diagnostic delay of NTM diseases in China, especially for rural patients with limited access to higher-level healthcare services.

Shojaei H, Heidarieh P, Hashemi A, Feizabadi MM: Daei Naser A; Species identification of neglected nontuberculous mycobacteria in a developing country. Jpn J Infect Dis. 2011, 64: 265-271.PubMed

Griffith DE: Nontuberculous mycobacterial lung disease. Curr Opin Infect Dis. 2010, 23: 185-190. 10.1097/QCO.0b013e328336ead6.CrossRefPubMed

Wang HX, Yue J, Han M, Yang JH, Gao RL, Jing LJ, Yang SS, Zhao YL: Nontuberculous mycobacteria: susceptibility pattern and prevalence rate in Shanghai from 2005 to 2008. Chin Med J. 2010, 123: 184-187.PubMed

Jing H, Wang H, Wang Y, Deng Y, Li X, Liu Z, Graviss EA, Ma X: Prevalence of Nontuberculous Mycobacteria Infection, China, 2004–2009. Emerg Infect Dis. 2012, 18: 527-528. 10.3201/eid1803.110175.PubMedCentralCrossRefPubMed

Griffith D, Aksamit T, Brown-Elliott B, Catanzaro A, Daley C, Gordin F, Holland SM, Horsburgh R, Huitt G, Iademarco MF, Iseman M, Olivier K, Ruoss S, Von Reyn CF, Wallace RJ, Winthrop K: An Official ATS/IDSA Statement: Diagnosis, Treatment, and Prevention of Nontuberculous Mycobacterial Diseases. Am J Respir Crit Care Med. 2007, 175: 367-416. 10.1164/rccm.200604-571ST.CrossRefPubMed

Kent PT, Kubica GP: Public Health Mycobacteriology: a Guide for the Level III Laboratory. 1985, Atlanta, GA: U.S. Department of Health and Human Services/Public Health Service/Centers for Disease Control

Han XY, Pham AS, Tarrand JJ, Sood PK, Luthra R: Rapid and accurate identification of mycobacteria by sequencing hypervariable regions of the 16S ribosomal RNA gene. Am J Clin Pathol. 2002, 118: 796-801. 10.1309/HN44-XQYM-JMAQ-2EDL.CrossRefPubMed

Wong TC, Chan WF, Tsang WL, Yeung SH, Ip FK: Mycobacterium farcinogenes infection after total hip arthroplasty. J Arthroplasty. 2005, 20: 684-687. 10.1016/j.arth.2005.03.001.CrossRefPubMed

Chinese Center for Disease Control and Prevention: The Fifth National Tuberculosis Surveillance of China. 2011, Beijing,China: Military Medical Science Press

10.

Adjemian J, Olivier KN, Prevots DR: Nontuberculous Mycobacteria among Cystic Fibrosis Patients in the United States: Screening Practices and Environmental Risk. Am J Respir Crit Care Med. 2014, [Epub ahead of print]

Title: Diagnostic delay of pulmonary nontuberculous mycobacterial infection in China
Authors: Hui Jing
Wanming Tan
Yunfeng Deng
Dachuan Gao
Liang Li
Zhiming Lu
Edward A Graviss
Xin Ma
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Multidisciplinary Respiratory Medicine / Issue 1/2014
Electronic ISSN: 2049-6958
DOI: https://doi.org/10.1186/2049-6958-9-48

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