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European Journal of Medical Research
Published in: European Journal of Medical Research 6/2011

01-12-2011 | Review

The role of neoadjuvant and adjuvant treatment for adenocarcinoma of the upper gastrointestinal tract

Authors: C Matuschek, E Bölke, M Peiper, WT Knoefel, W Budach, A Erhardt, A Scherer, PA Gerber, BA Buhren, N Gattermann, SE Baldus, E Rusnak, V Shukla, K Orth

Published in: European Journal of Medical Research | Issue 6/2011

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Abstract

Both locally advanced adenocarcinoma of the stomach and gastro-esophageal junction are associated with poor prognosis due to the lack of effective treatment. Recently multimodal treatment consisting of neoadjuvant chemotherapy in combination with radiotherapy is reported to improve survival when compared to surgery alone. Neoadjuvant therapy in these locally advanced tumors allows for early tumor responses and the extent of tumor regression that can be achieved is considered a significant prognostic factor. This, in turn, increases the resectability of these tumors. Also due to the high frequency of lymph node metastasis, patients with locally advanced adenocarcinoma should undergo a D2 lymphadenectomy. Postoperative chemoradiation and perioperative chemotherapy have been studied in gastric adenocarcinomas and showed a survival benefit. However, the surgical techniques used in these trials are no longer considered to be standard by today's surgical practice. In addition, there are no standard recommendations for adjuvant chemotherapy or chemoradiation after R0 resection and adequate lymph node dissection.
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Metadata
Title
The role of neoadjuvant and adjuvant treatment for adenocarcinoma of the upper gastrointestinal tract
Authors
C Matuschek
E Bölke
M Peiper
WT Knoefel
W Budach
A Erhardt
A Scherer
PA Gerber
BA Buhren
N Gattermann
SE Baldus
E Rusnak
V Shukla
K Orth
Publication date
01-12-2011
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 6/2011
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/2047-783X-16-6-265

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