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01-12-2011 | Research

Immunohistochemical localization of notch signaling molecules in ameloblastomas

Authors: E Muraki, K Nakano, H Maeda, M Takayama, M Jinno, K Kubo, W Yoshida, H Hasegawa, T Kawakami

Published in: European Journal of Medical Research | Issue 6/2011

Abstract

We examined Notch signaling molecules, Notch1 and Jagged1, in serial large cases of typical solid/multicystic ameloblastoma. In general, Notch positive staining products were frequently detected in the cytoplasms of the cells. In the same cells, Jagged positive staining were also frequently observed, while only occasionally positive in peripheral cells, especially in cuboidal cells. The results showed that these morphogenesis regulation factors are closely related to cytological differentiation in neoplastic cells of ameloblastoma. The Notch and Jagged positive-cell ratios were frequently positive, and the ratios were nearly the same between the varied histopathological, cytological patterns. However, the less-differentiated cells were fewer in number than that of well-differentiated cells.

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Title: Immunohistochemical localization of notch signaling molecules in ameloblastomas
Authors: E Muraki
K Nakano
H Maeda
M Takayama
M Jinno
K Kubo
W Yoshida
H Hasegawa
T Kawakami
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: European Journal of Medical Research / Issue 6/2011
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/2047-783X-16-6-253

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Immunohistochemical localization of notch signaling molecules in ameloblastomas

Abstract

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