Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Medical Gas Research
Published in: Medical Gas Research 1/2011

Open Access 01-12-2011 | Commentary

Hyperbaric oxygen therapy promotes neurogenesis: where do we stand?

Authors: Jun Mu, Paul R Krafft, John H Zhang

Published in: Medical Gas Research | Issue 1/2011

Login to get access

Abstract

Neurogenesis in adults, initiated by injury to the central nervous system (CNS) presents an autologous repair mechanism. It has been suggested that hyperbaric oxygen therapy (HBOT) enhances neurogenesis which accordingly may improve functional outcome after CNS injury. In this present article we aim to review experimental as well as clinical studies on the subject of HBOT and neurogenesis. We demonstrate hypothetical mechanism of HBOT on cellular transcription factors including hypoxia-inducible factors (HIFs) and cAMP response element binding (CREB). We furthermore reveal the discrepancy between experimental findings and clinical trials in regards of HBOT. Further translational preclinical studies followed by improved clinical trials are needed to elucidate potential benefits of HBOT.
Appendix
Available only for authorised users
Literature
1.
Alvarez-Buylla A, Lim DA: For the long run: maintaining germinal niches in the adult brain. Neuron. 2004, 41 (5): 683-6. 10.1016/S0896-6273(04)00111-4.CrossRefPubMed
2.
Mychaskiw G: Hyperbaric oxygen therapy and neurologic disease: the time has come. Undersea Hyperb Med. 2010, 37 (2): xi-xiii.PubMed
3.
Matchett GA, Martin RD, Zhang JH: Hyperbaric oxygen therapy and cerebral ischemia: neuroprotective mechanisms. Neurol Res. 2009, 31 (2): 114-21. 10.1179/174313209X389857.CrossRefPubMed
4.
Wang XL, et al: Proliferation of neural stem cells correlates with Wnt-3 protein in hypoxic-ischemic neonate rats after hyperbaric oxygen therapy. Neuroreport. 2007, 18 (16): 1753-6. 10.1097/WNR.0b013e3282f0ec09.CrossRefPubMed
5.
Wang XL, et al: [Hyperbaric oxygen promotes the migration and differentiation of endogenous neural stem cells in neonatal rats with hypoxic-ischemic brain damage]. Zhongguo Dang Dai Er Ke Za Zhi. 2009, 11 (9): 749-52.PubMed
6.
Zhang XY, et al: The role of beta-catenin signaling pathway on proliferation of rats neural stem cells after hyperbaric oxygen therapy in vitro. Cell Mol Neurobiol. 2011, 31 (1): 101-9. 10.1007/s10571-010-9559-z.CrossRefPubMed
7.
Milosevic J, et al: Non-hypoxic stabilization of hypoxia-inducible factor alpha (HIF-alpha): relevance in neural progenitor/stem cells. Neurotox Res. 2009, 15 (4): 367-80. 10.1007/s12640-009-9043-z.CrossRefPubMed
8.
Tai PA, et al: Attenuating experimental spinal cord injury by hyperbaric oxygen: stimulating production of vasculoendothelial and glial cell line-derived neurotrophic growth factors and interleukin-10. J Neurotrauma. 2010, 27 (6): 1121-7. 10.1089/neu.2009.1162.CrossRefPubMed
9.
10.
Godman CA, et al: Hyperbaric oxygen treatment induces antioxidant gene expression. Ann N Y Acad Sci. 2010, 1197: 178-83. 10.1111/j.1749-6632.2009.05393.x.CrossRefPubMed
11.
Yang YJ, et al: Hyperbaric oxygen induces endogenous neural stem cells to proliferate and differentiate in hypoxic-ischemic brain damage in neonatal rats. Undersea Hyperb Med. 2008, 35 (2): 113-29.PubMed
12.
Zhang T, et al: Hyperbaric oxygen therapy improves neurogenesis and brain blood supply in piriform cortex in rats with vascular dementia. Brain Inj. 2010, 24 (11): 1350-7. 10.3109/02699052.2010.504525.CrossRefPubMed
13.
Gunther A, et al: Reduced infarct volume and differential effects on glial cell activation after hyperbaric oxygen treatment in rat permanent focal cerebral ischaemia. Eur J Neurosci. 2005, 21 (11): 3189-94. 10.1111/j.1460-9568.2005.04151.x.CrossRefPubMed
14.
Chen W, et al: HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model. Neurobiol Dis. 2008, 31 (3): 433-41. 10.1016/j.nbd.2008.05.020.PubMedCentralCrossRefPubMed
15.
Lanfranconi S, et al: Growth factors in ischemic stroke. J Cell Mol Med. 2009,
16.
Halterman MW, Federoff HJ: HIF-1alpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia. Exp Neurol. 1999, 159 (1): 65-72. 10.1006/exnr.1999.7160.CrossRefPubMed
17.
Mellor HR, Harris AL: The role of the hypoxia-inducible BH3-only proteins BNIP3 and BNIP3L in cancer. Cancer Metastasis Rev. 2007, 26 (3-4): 553-66. 10.1007/s10555-007-9080-0.CrossRefPubMed
18.
19.
Zhu DY, et al: Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci USA. 2004, 101 (25): 9453-7. 10.1073/pnas.0401063101.PubMedCentralCrossRefPubMed
20.
Mendoza-Paredes A, et al: Resuscitation with 100%, compared with 21%, oxygen following brief, repeated periods of apnea can protect vulnerable neonatal brain regions from apoptotic injury. Resuscitation. 2008, 76 (2): 261-70. 10.1016/j.resuscitation.2007.07.022.PubMedCentralCrossRefPubMed
21.
Li JS, et al: Hyperbaric oxygen preconditioning reduces ischemia-reperfusion injury by inhibition of apoptosis via mitochondrial pathway in rat brain. Neuroscience. 2009, 159 (4): 1309-15. 10.1016/j.neuroscience.2009.01.011.CrossRefPubMed
22.
Taylor CT, et al: Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia. Proc Natl Acad Sci USA. 2000, 97 (22): 12091-6. 10.1073/pnas.220211797.PubMedCentralCrossRefPubMed
23.
Lichtenwalner RJ, Parent JM: Adult neurogenesis and the ischemic forebrain. J Cereb Blood Flow Metab. 2006, 26 (1): 1-20. 10.1038/sj.jcbfm.9600170.CrossRefPubMed
24.
Shin HY, et al: Endogenous neurogenesis and neovascularization in the neocortex of the rat after focal cerebral ischemia. J Neurosci Res. 2008, 86 (2): 356-67. 10.1002/jnr.21494.CrossRefPubMed
25.
Singhal AB: A review of oxygen therapy in ischemic stroke. Neurol Res. 2007, 29 (2): 173-83. 10.1179/016164107X181815.CrossRefPubMed
26.
Poli S, Veltkamp R: Oxygen therapy in acute ischemic stroke-experimental efficacy and molecular mechanisms. Curr Mol Med. 2009, 9 (2): 227-41. 10.2174/156652409787581619.CrossRefPubMed
27.
Yin D, et al: Inhibition of apoptosis by hyperbaric oxygen in a rat focal cerebral ischemic model. J Cereb Blood Flow Metab. 2003, 23 (7): 855-64.CrossRefPubMed
28.
Yin D, Zhang JH: Delayed and multiple hyperbaric oxygen treatments expand therapeutic window in rat focal cerebral ischemic model. Neurocrit Care. 2005, 2 (2): 206-11. 10.1385/NCC:2:2:206.CrossRefPubMed
29.
Sun L, et al: Oxygen therapy reduces secondary hemorrhage after thrombolysis in thromboembolic cerebral ischemia. J Cereb Blood Flow Metab. 2010, 30 (9): 1651-60. 10.1038/jcbfm.2010.50.PubMedCentralCrossRefPubMed
30.
Carson S, et al: Hyperbaric oxygen therapy for stroke: a systematic review of the evidence. Clin Rehabil. 2005, 19 (8): 819-33. 10.1191/0269215505cr907oa.CrossRefPubMed
31.
Bennett MH, et al: Hyperbaric oxygen therapy for acute ischaemic stroke. Cochrane Database Syst Rev. 2005, CD004954-3
32.
Kernie SG, Parent JM: Forebrain neurogenesis after focal Ischemic and traumatic brain injury. Neurobiol Dis. 2010, 37 (2): 267-74. 10.1016/j.nbd.2009.11.002.PubMedCentralCrossRefPubMed
33.
McDonagh M, et al: Hyperbaric oxygen therapy for traumatic brain injury: a systematic review of the evidence. Arch Phys Med Rehabil. 2004, 85 (7): 1198-204. 10.1016/j.apmr.2003.12.026.CrossRefPubMed
34.
Rockswold SB, Rockswold GL, Defillo A: Hyperbaric oxygen in traumatic brain injury. Neurol Res. 2007, 29 (2): 162-72. 10.1179/016164107X181798.CrossRefPubMed
35.
Meyer MJ, et al: Acute management of acquired brain injury part I: an evidence-based review of non-pharmacological interventions. Brain Inj. 2010, 24 (5): 694-705. 10.3109/02699051003692118.CrossRefPubMed
36.
Wegiel J, et al: The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes. Acta Neuropathol. 2010, 119 (6): 755-70. 10.1007/s00401-010-0655-4.PubMedCentralCrossRefPubMed
37.
Rossignol DA, et al: Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial. BMC Pediatr. 2009, 9: 21-10.1186/1471-2431-9-21.PubMedCentralCrossRefPubMed
38.
Jepson B, et al: Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children with Autism Spectrum Disorders. J Autism Dev Disord. 2011, 41 (5): 575-88. 10.1007/s10803-010-1075-y.CrossRefPubMed
39.
Palmer TD, Willhoite AR, Gage FH: Vascular niche for adult hippocampal neurogenesis. J Comp Neurol. 2000, 425 (4): 479-94. 10.1002/1096-9861(20001002)425:4<479::AID-CNE2>3.0.CO;2-3.CrossRefPubMed
40.
Feldmeier J, et al: Hyperbaric oxygen: does it promote growth or recurrence of malignancy?. Undersea Hyperb Med. 2003, 30 (1): 1-18.PubMed
41.
Taupin P: A dual activity of ROS and oxidative stress on adult neurogenesis and Alzheimer's disease. Cent Nerv Syst Agents Med Chem. 2010, 10 (1): 16-21.CrossRefPubMed
Metadata
Title
Hyperbaric oxygen therapy promotes neurogenesis: where do we stand?
Authors
Jun Mu
Paul R Krafft
John H Zhang
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Medical Gas Research / Issue 1/2011
Electronic ISSN: 2045-9912
DOI
https://doi.org/10.1186/2045-9912-1-14

Other articles of this Issue 1/2011

Medical Gas Research 1/2011 Go to the issue

Research

Early cognitive function, recovery and well-being after sevoflurane and xenon anaesthesia in the elderly: a double-blinded randomized controlled trial

Research

Hydrogen is neuroprotective against surgically induced brain injury

Research

Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide

Review

Hyperbaric oxygen therapy for traumatic brain injury

Research

Normobaric hyperoxia protects the blood brain barrier through inhibiting Nox2 containing NADPH oxidase in ischemic stroke

Review

Book Review: Gas Biology Research in Clinical Practice, edited by Toshikazu Yoshikawa and Yuji Naito
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Image Credits