Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Medical Gas Research
Published in: Medical Gas Research 1/2011

Open Access 01-12-2011 | Review

Hyperbaric oxygen therapy for traumatic brain injury

Authors: Lei Huang, Andre Obenaus

Published in: Medical Gas Research | Issue 1/2011

Login to get access

Abstract

Traumatic brain injury (TBI) is a major public health issue. The complexity of TBI has precluded the use of effective therapies. Hyperbaric oxygen therapy (HBOT) has been shown to be neuroprotective in multiple neurological disorders, but its efficacy in the management of TBI remains controversial. This review focuses on HBOT applications within the context of experimental and clinical TBI. We also discuss its potential neuroprotective mechanisms. Early or delayed multiple sessions of low atmospheric pressure HBOT can reduce intracranial pressure, improve mortality, as well as promote neurobehavioral recovery. The complimentary, synergistic actions of HBOT include improved tissue oxygenation and cellular metabolism, anti-apoptotic, and anti-inflammatory mechanisms. Thus HBOT may serve as a promising neuroprotective strategy that when combined with other therapeutic targets for TBI patients which could improve long-term outcomes.
Appendix
Available only for authorised users
Literature
1.
Gill AL, Bell CN: Hyperbaric Oxygen: Its Uses, Mechanisms of Action and Outcomes. QJM. 2004, 97: 385-395. 10.1093/qjmed/hch074.CrossRefPubMed
2.
Zhou Z, Daugherty WP, Sun D, Levasseur JE, Altememi N, Hamm RJ, et al: Protection of Mitochondrial Function and Improvement in Cognitive Recovery in Rats Treated with Hyperbaric Oxygen Following Lateral Fluid-Percussion Injury. J Neurosurg. 2007, 106: 687-694. 10.3171/jns.2007.106.4.687.CrossRefPubMed
3.
Daugherty WP, Levasseur JE, Sun D, Rockswold GL, Bullock MR: Effects of Hyperbaric Oxygen Therapy on Cerebral Oxygenation and Mitochondrial Function Following Moderate Lateral Fluid-Percussion Injury in Rats. J Neurosurg. 2004, 101: 499-504. 10.3171/jns.2004.101.3.0499.CrossRefPubMed
4.
Tolias CM, Reinert M, Seiler R, Gilman C, Scharf A, Bullock MR: Normobaric Hyperoxia--Induced Improvement in Cerebral Metabolism and Reduction in Intracranial Pressure in Patients with Severe Head Injury: A Prospective Historical Cohort-Matched Study. J Neurosurg. 2004, 101: 435-444. 10.3171/jns.2004.101.3.0435.CrossRefPubMed
5.
Rockswold SB, Rockswold GL, Vargo JM, Erickson CA, Sutton RL, Bergman TA, et al: Effects of Hyperbaric Oxygenation Therapy on Cerebral Metabolism and Intracranial Pressure in Severely Brain Injured Patients. J Neurosurg. 2001, 94: 403-411. 10.3171/jns.2001.94.3.0403.CrossRefPubMed
6.
Palzur E, Zaaroor M, Vlodavsky E, Milman F, Soustiel JF: Neuroprotective Effect of Hyperbaric Oxygen Therapy in Brain Injury Is Mediated by Preservation of Mitochondrial Membrane Properties. Brain Res. 2008, 1221: 126-133.CrossRefPubMed
7.
Jain KK: Origin of Textbook of Hyperbaric Medicine. 2004, Cambrige, MA: Hogrefe & Huber
8.
van Hulst RA, Haitsma JJ, Klein J, Lachmann B: Oxygen Tension under Hyperbaric Conditions in Healthy Pig Brain. Clin Physiol Funct Imaging. 2003, 23: 143-148. 10.1046/j.1475-097X.2003.00485.x.CrossRefPubMed
9.
Calvert JW, Cahill J, Zhang JH: Hyperbaric Oxygen and Cerebral Physiology. Neurol Res. 2007, 29: 132-141. 10.1179/016164107X174156.CrossRefPubMed
10.
Miller JD, Ledingham IM: Reduction of Increased Intracranial Pressure. Comparison between Hyperbaric Oxygen and Hyperventilation. Arch Neurol. 1971, 24: 210-216.CrossRefPubMed
11.
Lambertsen CJ, Dough RH, Cooper DY, Emmel GL, Loeschcke HH, Schmidt CF: Oxygen Toxicity; Effects in Man of Oxygen Inhalation at 1 and 3.5 Atmospheres Upon Blood Gas Transport, Cerebral Circulation and Cerebral Metabolism. J Appl Physiol. 1953, 5: 471-486.PubMed
12.
Sukoff MH, Ragatz RE: Hyperbaric Oxygenation for the Treatment of Acute Cerebral Edema. Neurosurgery. 1982, 10: 29-38. 10.1227/00006123-198201000-00006.CrossRefPubMed
13.
Kohshi K, Yokota A, Konda N, Kinoshita Y, Kajiwara H: Intracranial Pressure Responses During Hyperbaric Oxygen Therapy. Neurol Med Chir (Tokyo). 1991, 31: 575-581. 10.2176/nmc.31.575.CrossRef
14.
Rockswold SB, Rockswold GL, Zaun DA, Zhang X, Cerra CE, Bergman TA, et al: A Prospective, Randomized Clinical Trial to Compare the Effect of Hyperbaric to Normobaric Hyperoxia on Cerebral Metabolism, Intracranial Pressure, and Oxygen Toxicity in Severe Traumatic Brain Injury. J Neurosurg. 2010, 112: 1080-1094. 10.3171/2009.7.JNS09363.CrossRefPubMed
15.
Edwards ML: Hyperbaric Oxygen Therapy. Part 2: Application in Disease. J Vet Emerg Crit Care (San Antonio). 2010, 20: 289-297. 10.1111/j.1476-4431.2010.00535_1.x.CrossRef
16.
Mandal NG, White N, Wee MY: Carbon Monoxide Poisoning in a Parturient and the Use of Hyperbaric Oxygen for Treatment. Int J Obstet Anesth. 2001, 10: 71-74. 10.1054/ijoa.2000.0492.CrossRefPubMed
17.
Rockswold GL, Ford SE, Anderson DC, Bergman TA, Sherman RE: Results of a Prospective Randomized Trial for Treatment of Severely Brain-Injured Patients with Hyperbaric Oxygen. J Neurosurg. 1992, 76: 929-934. 10.3171/jns.1992.76.6.0929.CrossRefPubMed
18.
Dunn JE, Lawson DD: Effects of Hypobaric and Hyperbaric Oxygen on Experimental Brain Injury. Origins of Hyperbaric Medicine. Edited by: Brown IW, Cox BGs. 1966, Washington, DC: National Research Council, 447-454.
19.
Miller JD, Fitch W, Ledingham IM, Jennett WB: The Effect of Hyperbaric Oxygen on Experimentally Increased Intracranial Pressure. J Neurosurg. 1970, 33: 287-296. 10.3171/jns.1970.33.3.0287.CrossRefPubMed
20.
Hollin SA, Sukoff MH, Jacobson JH: The Protective Effect of Hyperbaric Oxygenation in Experimentally Produced Cerebral Edema and Compression. Prog Brain Res. 1968, 30: 479-489.CrossRefPubMed
21.
Sukoff MH, Hollin SA, Espinosa OE, Jacobson JH: The Protective Effect of Hyperbaric Oxygenation in Experimental Cerebral Edema. J Neurosurg. 1968, 29: 236-241. 10.3171/jns.1968.29.3.0236.CrossRefPubMed
22.
Moody RA, Mead CO, Ruamsuke S, Mullan S: Therapeutic Value of Oxygen at Normal and Hyperbaric Pressure in Experimental Head Injury. J Neurosurg. 1970, 32: 51-54. 10.3171/jns.1970.32.1.0051.CrossRefPubMed
23.
Hayakawa T, Kanai N, Kuroda R, Yamada R, Mogami H: Response of Cereborspinal Fluid Pressure to Hyperbaric Oxygenation. J Neurol Neurosurg Psychiatry. 1971, 34: 580-586. 10.1136/jnnp.34.5.580.PubMedCentralCrossRefPubMed
24.
Mink RB, Dutka AJ: Hyperbaric Oxygen after Global Cerebral Ischemia in Rabbits Does Not Promote Brain Lipid Peroxidation. Crit Care Med. 1995, 23: 1398-1404. 10.1097/00003246-199508000-00014.CrossRefPubMed
25.
Harch PG, Kriedt GL, Weisand MP, Van Meter KW, Sutherland RJ: Low Pressure Hyperbaric Oxygen Therapy Induces Cerebrovascular Changes and Improves Complex Learning/Memory in a Rat Open Head Bonk Chronic Brain Contusion Model. Undersea Hyperb Med. 1996, 23:
26.
Harch PG, Kriedt C, Van Meter KW, Sutherland RJ: Hyperbaric Oxygen Therapy Improves Spatial Learning and Memory in a Rat Model of Chronic Traumatic Brain Injury. Brain Res. 2007, 1174: 120-129.CrossRefPubMed
27.
Wang GH, Zhang XG, Jiang ZL, Li X, Peng LL, Li YC, et al: Neuroprotective Effects of Hyperbaric Oxygen Treatment on Traumatic Brain Injury in the Rat. J Neurotrauma. 2010, 27: 1733-1743. 10.1089/neu.2009.1175.CrossRefPubMed
28.
Marx RE, Ehler WJ, Tayapongsak P, Pierce LW: Relationship of Oxygen Dose to Angiogenesis Induction in Irradiated Tissue. Am J Surg. 1990, 160: 519-524. 10.1016/S0002-9610(05)81019-0.CrossRefPubMed
29.
Myers RA, Marx RE: Use of Hyperbaric Oxygen in Postradiation Head and Neck Surgery. NCI Monogr. 1990, 151-157.
30.
Golden ZL, Neubauer R, Golden CJ, Greene L, Marsh J, Mleko A: Improvement in Cerebral Metabolism in Chronic Brain Injury after Hyperbaric Oxygen Therapy. Int J Neurosci. 2002, 112: 119-131. 10.1080/00207450212027.CrossRefPubMed
31.
Neubauer RA, Gottlieb SF, Miale A: Identification of Hypometabolic Areas in the Brain Using Brain Imaging and Hyperbaric Oxygen. Clin Nucl Med. 1992, 17: 477-481. 10.1097/00003072-199206000-00010.CrossRefPubMed
32.
33.
Bennett MH, Trytko B, Jonker B: Hyperbaric Oxygen Therapy for the Adjunctive Treatment of Traumatic Brain Injury. Cochrane Database Syst Rev. 2004, CD004609-
34.
Kumaria A, Tolias CM: Normobaric Hyperoxia Therapy for Traumatic Brain Injury and Stroke: A Review. Br J Neurosurg. 2009, 23: 576-584. 10.3109/02688690903050352.CrossRefPubMed
35.
Narotam PK, Morrison JF, Nathoo N: Brain Tissue Oxygen Monitoring in Traumatic Brain Injury and Major Trauma: Outcome Analysis of a Brain Tissue Oxygen-Directed Therapy. J Neurosurg. 2009, 111: 672-682. 10.3171/2009.4.JNS081150.CrossRefPubMed
36.
Nortje J, Coles JP, Timofeev I, Fryer TD, Aigbirhio FI, Smielewski P, et al: Effect of Hyperoxia on Regional Oxygenation and Metabolism after Severe Traumatic Brain Injury: Preliminary Findings. Crit Care Med. 2008, 36: 273-281. 10.1097/01.CCM.0000292014.60835.15.CrossRefPubMed
37.
Rockswold SB, Rockswold GL, Defillo A: Hyperbaric Oxygen in Traumatic Brain Injury. Neurol Res. 2007, 29: 162-172. 10.1179/016164107X181798.CrossRefPubMed
38.
Contreras FL, Kadekaro M, Eisenberg HM: The Effect of Hyperbaric Oxygen on Glucose Utilization in a Freeze-Traumatized Rat Brain. J Neurosurg. 1988, 68: 137-141. 10.3171/jns.1988.68.1.0137.CrossRefPubMed
39.
Azbill RD, Mu X, Bruce-Keller AJ, Mattson MP, Springer JE: Impaired Mitochondrial Function, Oxidative Stress and Altered Antioxidant Enzyme Activities Following Traumatic Spinal Cord Injury. Brain Res. 1997, 765: 283-290. 10.1016/S0006-8993(97)00573-8.CrossRefPubMed
40.
Springer JE, Azbill RD, Carlson SL: A Rapid and Sensitive Assay for Measuring Mitochondrial Metabolic Activity in Isolated Neural Tissue. Brain Res Brain Res Protoc. 1998, 2: 259-263. 10.1016/S1385-299X(97)00045-7.CrossRefPubMed
41.
Vlodavsky E, Palzur E, Feinsod M, Soustiel JF: Evaluation of the Apoptosis-Related Proteins of the Bcl-2 Family in the Traumatic Penumbra Area of the Rat Model of Cerebral Contusion, Treated by Hyperbaric Oxygen Therapy: A Quantitative Immunohistochemical Study. Acta Neuropathol. 2005, 110: 120-126. 10.1007/s00401-004-0946-8.CrossRefPubMed
42.
Vlodavsky E, Palzur E, Soustiel JF: Hyperbaric Oxygen Therapy Reduces Neuroinflammation and Expression of Matrix Metalloproteinase-9 in the Rat Model of Traumatic Brain Injury. Neuropathol Appl Neurobiol. 2006, 32: 40-50. 10.1111/j.1365-2990.2005.00698.x.CrossRefPubMed
43.
Palzur E, Vlodavsky E, Mulla H, Arieli R, Feinsod M, Soustiel JF: Hyperbaric Oxygen Therapy for Reduction of Secondary Brain Damage in Head Injury: An Animal Model of Brain Contusion. J Neurotrauma. 2004, 21: 41-48. 10.1089/089771504772695931.CrossRefPubMed
44.
Korsmeyer SJ, Shutter JR, Veis DJ, Merry DE, Oltvai ZN: Bcl-2/Bax: A Rheostat That Regulates an Anti-Oxidant Pathway and Cell Death. Semin Cancer Biol. 1993, 4: 327-332.PubMed
45.
Sharpe JC, Arnoult D, Youle RJ: Control of Mitochondrial Permeability by Bcl-2 Family Members. Biochim Biophys Acta. 2004, 1644: 107-113. 10.1016/j.bbamcr.2003.10.016.CrossRefPubMed
46.
Shimizu S, Narita M, Tsujimoto Y: Bcl-2 Family Proteins Regulate the Release of Apoptogenic Cytochrome C by the Mitochondrial Channel Vdac. Nature. 1999, 399: 483-487. 10.1038/20959.CrossRefPubMed
47.
Calvert JW, Zhou C, Nanda A, Zhang JH: Effect of Hyperbaric Oxygen on Apoptosis in Neonatal Hypoxia-Ischemia Rat Model. J Appl Physiol. 2003, 95: 2072-2080.CrossRefPubMed
48.
Yin D, Zhou C, Kusaka I, Calvert JW, Parent AD, Nanda A, et al: Inhibition of Apoptosis by Hyperbaric Oxygen in a Rat Focal Cerebral Ischemic Model. J Cereb Blood Flow Metab. 2003, 23: 855-864.CrossRefPubMed
49.
Cuzner ML, Opdenakker G: Plasminogen Activators and Matrix Metalloproteases, Mediators of Extracellular Proteolysis in Inflammatory Demyelination of the Central Nervous System. J Neuroimmunol. 1999, 94: 1-14. 10.1016/S0165-5728(98)00241-0.CrossRefPubMed
50.
Wennersten A, Holmin S, Mathiesen T: Characterization of Bax and Bcl-2 in Apoptosis after Experimental Traumatic Brain Injury in the Rat. Acta Neuropathol. 2003, 105: 281-288.PubMed
51.
Hu SL, Hu R, Li F, Liu Z, Xia YZ, Cui GY, et al: Hyperbaric Oxygen Preconditioning Protects against Traumatic Brain Injury at High Altitude. Acta Neurochir Suppl. 2008, 105: 191-196. 10.1007/978-3-211-09469-3_37.CrossRefPubMed
Metadata
Title
Hyperbaric oxygen therapy for traumatic brain injury
Authors
Lei Huang
Andre Obenaus
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Medical Gas Research / Issue 1/2011
Electronic ISSN: 2045-9912
DOI
https://doi.org/10.1186/2045-9912-1-21

Other articles of this Issue 1/2011

Medical Gas Research 1/2011 Go to the issue

Research

RNA interference-mediated silencing of BACE and APP attenuates the isoflurane-induced caspase activation

Review

Emergent role of gasotransmitters in ischemia-reperfusion injury

Review

Oxygen/ozone as a medical gas mixture. A critical evaluation of the various methods clarifies positive and negative aspects

Research

Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies

Research

Early cognitive function, recovery and well-being after sevoflurane and xenon anaesthesia in the elderly: a double-blinded randomized controlled trial

Commentary

The 2011 Medical Molecular Hydrogen Symposium: An inaugural symposium of the journal Medical Gas Research
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Image Credits