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Published in: Medical Gas Research 1/2011

Open Access 01-12-2011 | Commentary

The 2011 Medical Molecular Hydrogen Symposium: An inaugural symposium of the journal Medical Gas Research

Authors: Shigeo Ohta, Atsunori Nakao, Kinji Ohno

Published in: Medical Gas Research | Issue 1/2011

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Abstract

This report summarizes a brief description/history of the Hydrogen Research Meetings as well as key presentations/oral abstracts delivered in the most recent symposium. Additionally, we introduced 38 diseases and physiological states for which hydrogen exhibits beneficial effects.
Appendix
Available only for authorised users
Literature
1.
go back to reference Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007, 13: 688-694. 10.1038/nm1577.CrossRefPubMed Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007, 13: 688-694. 10.1038/nm1577.CrossRefPubMed
2.
go back to reference Cai J, Kang Z, Liu WW, Luo X, Qiang S, Zhang JH, Ohta S, Sun X, Xu W, Tao H, Li R: Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett. 2008, 441: 167-172. 10.1016/j.neulet.2008.05.077.CrossRefPubMed Cai J, Kang Z, Liu WW, Luo X, Qiang S, Zhang JH, Ohta S, Sun X, Xu W, Tao H, Li R: Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett. 2008, 441: 167-172. 10.1016/j.neulet.2008.05.077.CrossRefPubMed
3.
go back to reference Buchholz BM, Kaczorowski DJ, Sugimoto R, Yang R, Wang Y, Billiar TR, McCurry KR, Bauer AJ, Nakao A: Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant. 2008, 8: 2015-2024. 10.1111/j.1600-6143.2008.02359.x.CrossRefPubMed Buchholz BM, Kaczorowski DJ, Sugimoto R, Yang R, Wang Y, Billiar TR, McCurry KR, Bauer AJ, Nakao A: Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant. 2008, 8: 2015-2024. 10.1111/j.1600-6143.2008.02359.x.CrossRefPubMed
4.
go back to reference Cardinal JS, Zhan JH, Wang YN, Sugimoto R, Tsung A, McCurry KR, Billiar TR, Nakao A: Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney Int. 2010, 77: 101-109. 10.1038/ki.2009.421.CrossRefPubMed Cardinal JS, Zhan JH, Wang YN, Sugimoto R, Tsung A, McCurry KR, Billiar TR, Nakao A: Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney Int. 2010, 77: 101-109. 10.1038/ki.2009.421.CrossRefPubMed
5.
go back to reference Kajiya M, Sato K, Silva MJ, Ouhara K, Do PM, Shanmugam KT, Kawai T: Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Biochem Biophys Res Commun. 2009, 386: 316-321. 10.1016/j.bbrc.2009.06.024.CrossRefPubMed Kajiya M, Sato K, Silva MJ, Ouhara K, Do PM, Shanmugam KT, Kawai T: Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Biochem Biophys Res Commun. 2009, 386: 316-321. 10.1016/j.bbrc.2009.06.024.CrossRefPubMed
6.
go back to reference Sato Y, Kajiyama S, Amano A, Kondo Y, Sasaki T, Handa S, Takahashi R, Fukui M, Hasegawa G, Nakamura N, et al: Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem Biophys Res Commun. 2008, 375: 346-350. 10.1016/j.bbrc.2008.08.020.CrossRefPubMed Sato Y, Kajiyama S, Amano A, Kondo Y, Sasaki T, Handa S, Takahashi R, Fukui M, Hasegawa G, Nakamura N, et al: Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem Biophys Res Commun. 2008, 375: 346-350. 10.1016/j.bbrc.2008.08.020.CrossRefPubMed
7.
go back to reference Matchett GA, Fathali N, Hasegawa Y, Jadhav V, Ostrowski RP, Martin RD, Dorotta IR, Sun X, Zhang JH: Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models. Brain Res. 2009, 1259: 90-97.CrossRefPubMed Matchett GA, Fathali N, Hasegawa Y, Jadhav V, Ostrowski RP, Martin RD, Dorotta IR, Sun X, Zhang JH: Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models. Brain Res. 2009, 1259: 90-97.CrossRefPubMed
8.
go back to reference Cai JM, Kang ZM, Liu K, Liu WW, Li RP, Zhang JH, Luo X, Sun XJ: Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res. 2009, 1256: 129-137.CrossRefPubMed Cai JM, Kang ZM, Liu K, Liu WW, Li RP, Zhang JH, Luo X, Sun XJ: Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res. 2009, 1256: 129-137.CrossRefPubMed
9.
go back to reference Domoki F, Olah O, Zimmermann A, Nemeth I, Toth-Szuki V, Hugyecz M, Temesvari P, Bart F: Hydrogen is Neuroprotective and Preserves Cerebrovascular Reactivity in Asphyxiated Newborn Pigs. Pediatr Res. 2010, 68: 387-392.PubMed Domoki F, Olah O, Zimmermann A, Nemeth I, Toth-Szuki V, Hugyecz M, Temesvari P, Bart F: Hydrogen is Neuroprotective and Preserves Cerebrovascular Reactivity in Asphyxiated Newborn Pigs. Pediatr Res. 2010, 68: 387-392.PubMed
10.
go back to reference Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S: Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice. Neuropsychopharmacology. 2009, 34: 501-508. 10.1038/npp.2008.95.CrossRefPubMed Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S: Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice. Neuropsychopharmacology. 2009, 34: 501-508. 10.1038/npp.2008.95.CrossRefPubMed
11.
go back to reference Li J, Wang C, Zhang JH, Cai JM, Cao YP, Sun XJ: Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress. Brain Res. 2010, 1328: 152-161.CrossRefPubMed Li J, Wang C, Zhang JH, Cai JM, Cao YP, Sun XJ: Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress. Brain Res. 2010, 1328: 152-161.CrossRefPubMed
12.
go back to reference Gu Y, Huang CS, Inoue T, Yamashita T, Ishida T, Kang KM, Nakao A: Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice. Journal of Clinical Biochemistry and Nutrition. 2010, 46: 269-276. 10.3164/jcbn.10-19.PubMedCentralCrossRefPubMed Gu Y, Huang CS, Inoue T, Yamashita T, Ishida T, Kang KM, Nakao A: Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice. Journal of Clinical Biochemistry and Nutrition. 2010, 46: 269-276. 10.3164/jcbn.10-19.PubMedCentralCrossRefPubMed
13.
go back to reference Fu Y, Ito M, Fujita Y, Ito M, Ichihara M, Masuda A, Suzuki Y, Maesawa S, Kajita Y, Hirayama M, et al: Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci Lett. 2009, 453: 81-85. 10.1016/j.neulet.2009.02.016.CrossRefPubMed Fu Y, Ito M, Fujita Y, Ito M, Ichihara M, Masuda A, Suzuki Y, Maesawa S, Kajita Y, Hirayama M, et al: Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci Lett. 2009, 453: 81-85. 10.1016/j.neulet.2009.02.016.CrossRefPubMed
14.
go back to reference Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, et al: Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. PLoS One. 2009, 4: e7247-10.1371/journal.pone.0007247.PubMedCentralCrossRefPubMed Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, et al: Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. PLoS One. 2009, 4: e7247-10.1371/journal.pone.0007247.PubMedCentralCrossRefPubMed
15.
go back to reference Chen CH, Manaenko A, Zhan Y, Liu WW, Ostrowki RP, Tang J, Zhang JH: Hydrogen Gas Reduced Acute Hyperglycemia-Enhanced Hemorrhagic Transformation In A Focal Ischemia Rat Model. Neuroscience. 2010, 169: 402-414. 10.1016/j.neuroscience.2010.04.043.PubMedCentralCrossRefPubMed Chen CH, Manaenko A, Zhan Y, Liu WW, Ostrowki RP, Tang J, Zhang JH: Hydrogen Gas Reduced Acute Hyperglycemia-Enhanced Hemorrhagic Transformation In A Focal Ischemia Rat Model. Neuroscience. 2010, 169: 402-414. 10.1016/j.neuroscience.2010.04.043.PubMedCentralCrossRefPubMed
16.
go back to reference Ji XT, Liu WB, Xie KL, Liu WP, Qu Y, Chao XD, Chen T, Zhou J, Fei Z: Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. Brain Res. 2010, 1354: 196-205.CrossRefPubMed Ji XT, Liu WB, Xie KL, Liu WP, Qu Y, Chao XD, Chen T, Zhou J, Fei Z: Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. Brain Res. 2010, 1354: 196-205.CrossRefPubMed
17.
go back to reference Chen CW, Chen QB, Mao YF, Xu SM, Xia CY, Shi XY, Zhang JH, Yuan HB, Sun XJ: Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats. Neurochem Res. 2010, 35: 1111-1118. 10.1007/s11064-010-0162-y.CrossRefPubMed Chen CW, Chen QB, Mao YF, Xu SM, Xia CY, Shi XY, Zhang JH, Yuan HB, Sun XJ: Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats. Neurochem Res. 2010, 35: 1111-1118. 10.1007/s11064-010-0162-y.CrossRefPubMed
18.
go back to reference Oharazawa H, Igarashi T, Yokota T, Fujii H, Suzuki H, Machide M, Takahashi H, Ohta S, Ohsawa I: Protection of the Retina by Rapid Diffusion of Hydrogen: Administration of Hydrogen-Loaded Eye Drops in Retinal Ischemia-Reperfusion Injury. Invest Ophthalmol Vis Sci. 2010, 51: 487-492. 10.1167/iovs.09-4089.CrossRefPubMed Oharazawa H, Igarashi T, Yokota T, Fujii H, Suzuki H, Machide M, Takahashi H, Ohta S, Ohsawa I: Protection of the Retina by Rapid Diffusion of Hydrogen: Administration of Hydrogen-Loaded Eye Drops in Retinal Ischemia-Reperfusion Injury. Invest Ophthalmol Vis Sci. 2010, 51: 487-492. 10.1167/iovs.09-4089.CrossRefPubMed
19.
go back to reference Kubota M, Shimmura S, Kubota S, Miyashita H, Kato N, Noda K, Ozawa Y, Usui T, Ishida S, Umezawa K, Kurihara T, Tsubota K: Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Invest Ophthalmol Vis Sci. 2011, 52: 427-433. 10.1167/iovs.10-6167.CrossRefPubMed Kubota M, Shimmura S, Kubota S, Miyashita H, Kato N, Noda K, Ozawa Y, Usui T, Ishida S, Umezawa K, Kurihara T, Tsubota K: Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Invest Ophthalmol Vis Sci. 2011, 52: 427-433. 10.1167/iovs.10-6167.CrossRefPubMed
20.
go back to reference Kikkawa YS, Nakagawa T, Horie RT, Ito J: Hydrogen protects auditory hair cells from free radicals. Neuroreport. 2009, 20: 689-694. 10.1097/WNR.0b013e32832a5c68.CrossRefPubMed Kikkawa YS, Nakagawa T, Horie RT, Ito J: Hydrogen protects auditory hair cells from free radicals. Neuroreport. 2009, 20: 689-694. 10.1097/WNR.0b013e32832a5c68.CrossRefPubMed
21.
go back to reference Taura A, Kikkawa YS, Nakagawa T, Ito J: Hydrogen protects vestibular hair cells from free radicals. Acta Otolaryngol (Stockh). 2010, 130: 95-100.CrossRef Taura A, Kikkawa YS, Nakagawa T, Ito J: Hydrogen protects vestibular hair cells from free radicals. Acta Otolaryngol (Stockh). 2010, 130: 95-100.CrossRef
22.
go back to reference Lin Y, Kashio A, Sakamoto T, Suzukawa K, Kakigi A, Yamasoba T: Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs. Neurosci Lett. 2011, 487: 12-16. 10.1016/j.neulet.2010.09.064.CrossRefPubMed Lin Y, Kashio A, Sakamoto T, Suzukawa K, Kakigi A, Yamasoba T: Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs. Neurosci Lett. 2011, 487: 12-16. 10.1016/j.neulet.2010.09.064.CrossRefPubMed
23.
go back to reference Ye J, Li Y, Hamasaki T, Nakamichi N, Komatsu T, Kashiwagi T, Teruya K, Nishikawa R, Kawahara T, Osada K, et al: Inhibitory effect of electrolyzed reduced water on tumor angiogenesis. Biological & Pharmaceutical Bulletin. 2008, 31: 19-26. 10.1248/bpb.31.19.CrossRef Ye J, Li Y, Hamasaki T, Nakamichi N, Komatsu T, Kashiwagi T, Teruya K, Nishikawa R, Kawahara T, Osada K, et al: Inhibitory effect of electrolyzed reduced water on tumor angiogenesis. Biological & Pharmaceutical Bulletin. 2008, 31: 19-26. 10.1248/bpb.31.19.CrossRef
24.
go back to reference Zheng J, Liu K, Kang ZM, Cai JM, Liu WW, Xu WG, Li RP, Tao HY, Zhang JH, Sun XJ: Saturated hydrogen saline protects the lung against oxygen toxicity. Undersea Hyperb Med. 2010, 37: 185-192.PubMed Zheng J, Liu K, Kang ZM, Cai JM, Liu WW, Xu WG, Li RP, Tao HY, Zhang JH, Sun XJ: Saturated hydrogen saline protects the lung against oxygen toxicity. Undersea Hyperb Med. 2010, 37: 185-192.PubMed
25.
go back to reference Sun QA, Cai JM, Liu SL, Liu Y, Xu WG, Tao HY, Sun XJ: Hydrogen-Rich Saline Provides Protection Against Hyperoxic Lung Injury. J Surg Res. 2011, 165: E43-E49. 10.1016/j.jss.2010.09.024.CrossRefPubMed Sun QA, Cai JM, Liu SL, Liu Y, Xu WG, Tao HY, Sun XJ: Hydrogen-Rich Saline Provides Protection Against Hyperoxic Lung Injury. J Surg Res. 2011, 165: E43-E49. 10.1016/j.jss.2010.09.024.CrossRefPubMed
26.
go back to reference Kawamura T, Huang CS, Tochigi N, Lee S, Shigemura N, Billiar TR, Okumura M, Nakao A, Toyoda Y: Inhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-Induced Ischemia/Reperfusion Injury in Rats. Transplantation. 2010, 90: 1344-1351. 10.1097/TP.0b013e3181fe1357.CrossRefPubMed Kawamura T, Huang CS, Tochigi N, Lee S, Shigemura N, Billiar TR, Okumura M, Nakao A, Toyoda Y: Inhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-Induced Ischemia/Reperfusion Injury in Rats. Transplantation. 2010, 90: 1344-1351. 10.1097/TP.0b013e3181fe1357.CrossRefPubMed
27.
go back to reference Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, Endo J, Katayama T, Kawamura A, Kohsaka S, et al: Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun. 2008, 373: 30-35. 10.1016/j.bbrc.2008.05.165.CrossRefPubMed Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, Endo J, Katayama T, Kawamura A, Kohsaka S, et al: Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun. 2008, 373: 30-35. 10.1016/j.bbrc.2008.05.165.CrossRefPubMed
28.
go back to reference Sun Q, Kang ZM, Cai JM, Liu WW, Liu Y, Zhang JH, Denoble PJ, Tao HY, Sun XJ: Hydrogen-Rich Saline Protects Myocardium Against Ischemia/Reperfusion Injury in Rats. Exp Biol Med. 2009, 234: 1212-1219. 10.3181/0812-RM-349.CrossRef Sun Q, Kang ZM, Cai JM, Liu WW, Liu Y, Zhang JH, Denoble PJ, Tao HY, Sun XJ: Hydrogen-Rich Saline Protects Myocardium Against Ischemia/Reperfusion Injury in Rats. Exp Biol Med. 2009, 234: 1212-1219. 10.3181/0812-RM-349.CrossRef
29.
go back to reference Nakao A, Kaczorowski DJ, Wang YN, Cardinal JS, Buchholz BM, Sugimoto R, Tobita K, Lee S, Toyoda Y, Billiar TR, McCurry KR: Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. J Heart Lung Transplant. 2010, 29: 544-553. 10.1016/j.healun.2009.10.011.CrossRefPubMed Nakao A, Kaczorowski DJ, Wang YN, Cardinal JS, Buchholz BM, Sugimoto R, Tobita K, Lee S, Toyoda Y, Billiar TR, McCurry KR: Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. J Heart Lung Transplant. 2010, 29: 544-553. 10.1016/j.healun.2009.10.011.CrossRefPubMed
30.
go back to reference Qian LR, Cao F, Cui JG, Wang YC, Huang YC, Chuai YH, Zaho LQ, Jiang H, Cai JM: The Potential Cardioprotective Effects of Hydrogen in Irradiated Mice. J Radiat Res (Tokyo). 2010, 51: 741-747. 10.1269/jrr.10093.CrossRef Qian LR, Cao F, Cui JG, Wang YC, Huang YC, Chuai YH, Zaho LQ, Jiang H, Cai JM: The Potential Cardioprotective Effects of Hydrogen in Irradiated Mice. J Radiat Res (Tokyo). 2010, 51: 741-747. 10.1269/jrr.10093.CrossRef
31.
go back to reference Fukuda K, Asoh S, Ishikawa M, Yamamoto Y, Ohsawa I, Ohta S: Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun. 2007, 361: 670-674. 10.1016/j.bbrc.2007.07.088.CrossRefPubMed Fukuda K, Asoh S, Ishikawa M, Yamamoto Y, Ohsawa I, Ohta S: Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun. 2007, 361: 670-674. 10.1016/j.bbrc.2007.07.088.CrossRefPubMed
32.
go back to reference Liu Q, Shen WF, Sun HY, Fan DF, Nakao A, Cai JM, Yan G, Zhou WP, Shen RX, Yang JM, Sun XJ: Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice. Liver International. 2010, 30: 958-968. 10.1111/j.1478-3231.2010.02254.x.CrossRefPubMed Liu Q, Shen WF, Sun HY, Fan DF, Nakao A, Cai JM, Yan G, Zhou WP, Shen RX, Yang JM, Sun XJ: Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice. Liver International. 2010, 30: 958-968. 10.1111/j.1478-3231.2010.02254.x.CrossRefPubMed
33.
go back to reference Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S: Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol. 2009 Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S: Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol. 2009
34.
go back to reference Kitamura A, Kobayashi S, Matsushita T, Fujinawa H, Murase K: Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT. Br J Radiol. 2010, 83: 509-514. 10.1259/bjr/25604811.PubMedCentralCrossRefPubMed Kitamura A, Kobayashi S, Matsushita T, Fujinawa H, Murase K: Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT. Br J Radiol. 2010, 83: 509-514. 10.1259/bjr/25604811.PubMedCentralCrossRefPubMed
35.
go back to reference Nakayama M, Kabayama S, Nakano H, Zhu WJ, Terawaki H, Nakayama K, Katoh K, Satoh T, Ito S: Biological Effects of Electrolyzed Water in Hemodialysis. Nephron Clinical Practice. 2009, 112: C9-C15. 10.1159/000210569.CrossRefPubMed Nakayama M, Kabayama S, Nakano H, Zhu WJ, Terawaki H, Nakayama K, Katoh K, Satoh T, Ito S: Biological Effects of Electrolyzed Water in Hemodialysis. Nephron Clinical Practice. 2009, 112: C9-C15. 10.1159/000210569.CrossRefPubMed
36.
go back to reference Nakayama M, Nakano H, Hamada H, Itami N, Nakazawa R, Ito S: A novel bioactive haemodialysis system using dissolved dihydrogen (H-2) produced by water electrolysis: a clinical trial. Nephrology Dialysis Transplantation. 2010, 25: 3026-3033. 10.1093/ndt/gfq196.CrossRef Nakayama M, Nakano H, Hamada H, Itami N, Nakazawa R, Ito S: A novel bioactive haemodialysis system using dissolved dihydrogen (H-2) produced by water electrolysis: a clinical trial. Nephrology Dialysis Transplantation. 2010, 25: 3026-3033. 10.1093/ndt/gfq196.CrossRef
37.
go back to reference Chen H, Sun YP, Li Y, Liu WW, Xiang HG, Fan LY, Sun Q, Xu XY, Cai JM, Ruan CP, et al: Hydrogen-rich saline ameliorates the severity of L-arginine-induced acute pancreatitis in rats. Biochem Biophys Res Commun. 2010, 393: 308-313. 10.1016/j.bbrc.2010.02.005.CrossRefPubMed Chen H, Sun YP, Li Y, Liu WW, Xiang HG, Fan LY, Sun Q, Xu XY, Cai JM, Ruan CP, et al: Hydrogen-rich saline ameliorates the severity of L-arginine-induced acute pancreatitis in rats. Biochem Biophys Res Commun. 2010, 393: 308-313. 10.1016/j.bbrc.2010.02.005.CrossRefPubMed
38.
go back to reference Mao YF, Zheng XF, Cai JM, You XM, Deng XM, Zhang JH, Jiang L, Sun XJ: Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochem Biophys Res Commun. 2009, 381: 602-605. 10.1016/j.bbrc.2009.02.105.CrossRefPubMed Mao YF, Zheng XF, Cai JM, You XM, Deng XM, Zhang JH, Jiang L, Sun XJ: Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochem Biophys Res Commun. 2009, 381: 602-605. 10.1016/j.bbrc.2009.02.105.CrossRefPubMed
39.
go back to reference Zheng X, Mao Y, Cai J, Li Y, Liu W, Sun P, Zhang JH, Sun X, Yuan H: Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats. Free Radic Res. 2009, 43: 478-484. 10.1080/10715760902870603.CrossRefPubMed Zheng X, Mao Y, Cai J, Li Y, Liu W, Sun P, Zhang JH, Sun X, Yuan H: Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats. Free Radic Res. 2009, 43: 478-484. 10.1080/10715760902870603.CrossRefPubMed
40.
go back to reference Kajiya M, Silva MJ, Sato K, Ouhara K, Kawai T: Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochem Biophys Res Commun. 2009, 386: 11-15. 10.1016/j.bbrc.2009.05.117.CrossRefPubMed Kajiya M, Silva MJ, Sato K, Ouhara K, Kawai T: Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochem Biophys Res Commun. 2009, 386: 11-15. 10.1016/j.bbrc.2009.05.117.CrossRefPubMed
41.
go back to reference Ohsawa I, Nishimaki K, Yamagata K, Ishikawa M, Ohta S: Consumption of hydrogen water prevents atherosclerosis in apoliporotein E knockout mice. Biochem Biophys Res Commun. 2008, 377: 1195-1198. 10.1016/j.bbrc.2008.10.156.CrossRefPubMed Ohsawa I, Nishimaki K, Yamagata K, Ishikawa M, Ohta S: Consumption of hydrogen water prevents atherosclerosis in apoliporotein E knockout mice. Biochem Biophys Res Commun. 2008, 377: 1195-1198. 10.1016/j.bbrc.2008.10.156.CrossRefPubMed
42.
go back to reference Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, Kitawaki J, Imai S, Nakano K, Ohta M, et al: Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research. 2008, 28: 137-143. 10.1016/j.nutres.2008.01.008.CrossRefPubMed Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, Kitawaki J, Imai S, Nakano K, Ohta M, et al: Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research. 2008, 28: 137-143. 10.1016/j.nutres.2008.01.008.CrossRefPubMed
43.
go back to reference Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N: Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome-An Open Label Pilot Study. Journal of Clinical Biochemistry and Nutrition. 2010, 46: 140-149. 10.3164/jcbn.09-100.PubMedCentralCrossRefPubMed Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N: Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome-An Open Label Pilot Study. Journal of Clinical Biochemistry and Nutrition. 2010, 46: 140-149. 10.3164/jcbn.09-100.PubMedCentralCrossRefPubMed
44.
go back to reference Kamimura N, Nishimaki K, Ohsawa I, Ohta S: Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice. Obesity. 2011, Kamimura N, Nishimaki K, Ohsawa I, Ohta S: Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice. Obesity. 2011,
45.
go back to reference Saitoh Y, Okayasu H, Xiao L, Harata Y, Miwa N: Neutral pH hydrogen-enriched electrolyzed water achieves tumor-preferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression. Oncol Res. 2008, 17: 247-255. 10.3727/096504008786991620.CrossRefPubMed Saitoh Y, Okayasu H, Xiao L, Harata Y, Miwa N: Neutral pH hydrogen-enriched electrolyzed water achieves tumor-preferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression. Oncol Res. 2008, 17: 247-255. 10.3727/096504008786991620.CrossRefPubMed
46.
go back to reference Itoh T, Fujita Y, Ito M, Masuda A, Ohno K, Ichihara M, Kojima T, Nozawa Y, Ito M: Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun. 2009, 389: 651-656. 10.1016/j.bbrc.2009.09.047.CrossRefPubMed Itoh T, Fujita Y, Ito M, Masuda A, Ohno K, Ichihara M, Kojima T, Nozawa Y, Ito M: Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun. 2009, 389: 651-656. 10.1016/j.bbrc.2009.09.047.CrossRefPubMed
47.
go back to reference Xie KL, Yu YH, Pei YP, Hou LC, Chen SY, Xiong LZ, Wang GL: Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and hmgb1 release. Shock. 2010, 34: 90-97.CrossRefPubMed Xie KL, Yu YH, Pei YP, Hou LC, Chen SY, Xiong LZ, Wang GL: Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and hmgb1 release. Shock. 2010, 34: 90-97.CrossRefPubMed
48.
go back to reference Kawasaki H, Guan JJ, Tamama K: Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials. Biochem Biophys Res Commun. 2010, 397: 608-613. 10.1016/j.bbrc.2010.06.009.CrossRefPubMed Kawasaki H, Guan JJ, Tamama K: Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials. Biochem Biophys Res Commun. 2010, 397: 608-613. 10.1016/j.bbrc.2010.06.009.CrossRefPubMed
49.
go back to reference Qian LR, Cao F, Cui JG, Huang YC, Zhou XJ, Liu SL, Cai JM: Radioprotective effect of hydrogen in cultured cells and mice. Free Radic Res. 2010, 44: 275-282. 10.3109/10715760903468758.CrossRefPubMed Qian LR, Cao F, Cui JG, Huang YC, Zhou XJ, Liu SL, Cai JM: Radioprotective effect of hydrogen in cultured cells and mice. Free Radic Res. 2010, 44: 275-282. 10.3109/10715760903468758.CrossRefPubMed
50.
go back to reference Qian LR, Li BL, Cao F, Huang YC, Liu SL, Cai JM, Gao F: Hydrogen-rich pbs protects cultured human cells from ionizing radiation-induced cellular damage. Nuclear Technology & Radiation Protection. 2010, 25: 23-29. 10.2298/NTRP1001023Q.CrossRef Qian LR, Li BL, Cao F, Huang YC, Liu SL, Cai JM, Gao F: Hydrogen-rich pbs protects cultured human cells from ionizing radiation-induced cellular damage. Nuclear Technology & Radiation Protection. 2010, 25: 23-29. 10.2298/NTRP1001023Q.CrossRef
51.
go back to reference Shimouchi A, Nose K, Takaoka M, Hayashi H, Kondo T: Effect of Dietary Turmeric on Breath Hydrogen. Dig Dis Sci. 2009, 54: 1725-1729. 10.1007/s10620-008-0550-1.CrossRefPubMed Shimouchi A, Nose K, Takaoka M, Hayashi H, Kondo T: Effect of Dietary Turmeric on Breath Hydrogen. Dig Dis Sci. 2009, 54: 1725-1729. 10.1007/s10620-008-0550-1.CrossRefPubMed
52.
go back to reference Suzuki Y, Sano M, Hayashida K, Ohsawa I, Ohta S, Fukuda K: Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?. FEBS Lett. 2009, 583: 2157-2159. 10.1016/j.febslet.2009.05.052.CrossRefPubMed Suzuki Y, Sano M, Hayashida K, Ohsawa I, Ohta S, Fukuda K: Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?. FEBS Lett. 2009, 583: 2157-2159. 10.1016/j.febslet.2009.05.052.CrossRefPubMed
Metadata
Title
The 2011 Medical Molecular Hydrogen Symposium: An inaugural symposium of the journal Medical Gas Research
Authors
Shigeo Ohta
Atsunori Nakao
Kinji Ohno
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Medical Gas Research / Issue 1/2011
Electronic ISSN: 2045-9912
DOI
https://doi.org/10.1186/2045-9912-1-10

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