Current management of massive hemorrhage in trauma

go back to reference Lier H, Krep H, Schroeder S, Stuber F: Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. J Trauma. 2008, 65: 951-960.PubMedCrossRef Lier H, Krep H, Schroeder S, Stuber F: Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. J Trauma. 2008, 65: 951-960.PubMedCrossRef

go back to reference Stern SA, Dronen SC, Birrer P, Wang X: Effect of blood pressure on hemorrhage volume and survival in a near-fatal hemorrhage model incorporating a vascular injury. Ann Emerg Med. 1993, 22: 155-163.PubMedCrossRef Stern SA, Dronen SC, Birrer P, Wang X: Effect of blood pressure on hemorrhage volume and survival in a near-fatal hemorrhage model incorporating a vascular injury. Ann Emerg Med. 1993, 22: 155-163.PubMedCrossRef

go back to reference Practice guidelines for perioperative blood transfusion and adjuvant therapies: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies: Anesthesiology. 2006, 105: 198-208.CrossRef Practice guidelines for perioperative blood transfusion and adjuvant therapies: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies: Anesthesiology. 2006, 105: 198-208.CrossRef

go back to reference Dries DJ: Hypotensive resuscitation. Shock. 1996, 6: 311-316.PubMedCrossRef Dries DJ: Hypotensive resuscitation. Shock. 1996, 6: 311-316.PubMedCrossRef

go back to reference Krausz MM: Fluid resuscitation strategies in the Israeli army. J Trauma. 2003, 54: S39-S42.PubMed Krausz MM: Fluid resuscitation strategies in the Israeli army. J Trauma. 2003, 54: S39-S42.PubMed

go back to reference Soreide E, Deakin CD: Pre-hospital fluid therapy in the critically injured patient–a clinical update. Injury. 2005, 36: 1001-1010.PubMedCrossRef Soreide E, Deakin CD: Pre-hospital fluid therapy in the critically injured patient–a clinical update. Injury. 2005, 36: 1001-1010.PubMedCrossRef

go back to reference Dutton RP: Resuscitative strategies to maintain homeostasis during damage control surgery. Br J Surg. 2012, 99 (Suppl 1): 21-8. 10.1002/bjs.7731.:21-28.PubMedCrossRef Dutton RP: Resuscitative strategies to maintain homeostasis during damage control surgery. Br J Surg. 2012, 99 (Suppl 1): 21-8. 10.1002/bjs.7731.:21-28.PubMedCrossRef

go back to reference Johansson PI, Hansen MB, Sorensen H: Transfusion practice in massively bleeding patients: time for a change?. Vox Sang. 2005, 89: 92-96.PubMedCrossRef Johansson PI, Hansen MB, Sorensen H: Transfusion practice in massively bleeding patients: time for a change?. Vox Sang. 2005, 89: 92-96.PubMedCrossRef

go back to reference Holcomb JB, Jenkins D, Rhee P, Johannigman J, Mahoney P, Mehta S, Cox ED, Gehrke MJ, Beilman GJ, Schreiber M, Flaherty SF, Grathwohl KW, Spinella PC, Perkins JG, Beekley AC, McMullin NR, Park MS, Gonzalez EA, Wade CE, Dubick MA, Schwab CW, Moore FA, Champion HR, Hoyt DB, Hess JR: Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma. 2007, 62: 307-310.PubMedCrossRef Holcomb JB, Jenkins D, Rhee P, Johannigman J, Mahoney P, Mehta S, Cox ED, Gehrke MJ, Beilman GJ, Schreiber M, Flaherty SF, Grathwohl KW, Spinella PC, Perkins JG, Beekley AC, McMullin NR, Park MS, Gonzalez EA, Wade CE, Dubick MA, Schwab CW, Moore FA, Champion HR, Hoyt DB, Hess JR: Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma. 2007, 62: 307-310.PubMedCrossRef

go back to reference Chappell D, Jacob M, Hofmann-Kiefer K, Conzen P, Rehm M: A rational approach to perioperative fluid management. Anesthesiology. 2008, 109: 723-740.PubMedCrossRef Chappell D, Jacob M, Hofmann-Kiefer K, Conzen P, Rehm M: A rational approach to perioperative fluid management. Anesthesiology. 2008, 109: 723-740.PubMedCrossRef

go back to reference Mittermayr M, Streif W, Haas T, Fries D, Velik-Salchner C, Klingler A, Oswald E, Bach C, Schnapka-Koepf M, Innerhofer P: Hemostatic changes after crystalloid or colloid fluid administration during major orthopedic surgery: the role of fibrinogen administration. Anesth Analg. 2007, 105: 905-17. tablePubMedCrossRef Mittermayr M, Streif W, Haas T, Fries D, Velik-Salchner C, Klingler A, Oswald E, Bach C, Schnapka-Koepf M, Innerhofer P: Hemostatic changes after crystalloid or colloid fluid administration during major orthopedic surgery: the role of fibrinogen administration. Anesth Analg. 2007, 105: 905-17. tablePubMedCrossRef

go back to reference Nielsen VG: Colloids decrease clot propagation and strength: role of factor XIII-fibrin polymer and thrombin-fibrinogen interactions. Acta Anaesthesiol Scand. 2005, 49: 1163-1171.PubMedCrossRef Nielsen VG: Colloids decrease clot propagation and strength: role of factor XIII-fibrin polymer and thrombin-fibrinogen interactions. Acta Anaesthesiol Scand. 2005, 49: 1163-1171.PubMedCrossRef

go back to reference Knotzer H, Pajk W, Maier S, Dunser MW, Ulmer H, Schwarz B, Salak N, Hasibeder WR: Comparison of lactated Ringer's, gelatine and blood resuscitation on intestinal oxygen supply and mucosal tissue oxygen tension in haemorrhagic shock. Br J Anaesth. 2006, 97: 509-516.PubMedCrossRef Knotzer H, Pajk W, Maier S, Dunser MW, Ulmer H, Schwarz B, Salak N, Hasibeder WR: Comparison of lactated Ringer's, gelatine and blood resuscitation on intestinal oxygen supply and mucosal tissue oxygen tension in haemorrhagic shock. Br J Anaesth. 2006, 97: 509-516.PubMedCrossRef

go back to reference Thorsen K, Ringdal KG, Strand K, Soreide E, Hagemo J, Soreide K: Clinical and cellular effects of hypothermia, acidosis and coagulopathy in major injury. Br J Surg. 2011, 98: 894-907.PubMedCrossRef Thorsen K, Ringdal KG, Strand K, Soreide E, Hagemo J, Soreide K: Clinical and cellular effects of hypothermia, acidosis and coagulopathy in major injury. Br J Surg. 2011, 98: 894-907.PubMedCrossRef

go back to reference Mortier E, Ongenae M, De Baerdemaeker L, Herregods L, Den Blauwen N, Van Aken J, Rolly G: In vitro evaluation of the effect of profound haemodilution with hydroxyethyl starch 6%, modified fluid gelatin 4% and dextran 40 10% on coagulation profile measured by thromboelastography. Anaesthesia. 1997, 52: 1061-1064.PubMedCrossRef Mortier E, Ongenae M, De Baerdemaeker L, Herregods L, Den Blauwen N, Van Aken J, Rolly G: In vitro evaluation of the effect of profound haemodilution with hydroxyethyl starch 6%, modified fluid gelatin 4% and dextran 40 10% on coagulation profile measured by thromboelastography. Anaesthesia. 1997, 52: 1061-1064.PubMedCrossRef

go back to reference Hartog CS, Kohl M, Reinhart K: A Systematic Review of Third-Generation Hydroxyethyl Starch (HES 130/0.4) in Resuscitation: Safety Not Adequately Addressed. Anesth Analg. 2011, 112: 635-645.PubMedCrossRef Hartog CS, Kohl M, Reinhart K: A Systematic Review of Third-Generation Hydroxyethyl Starch (HES 130/0.4) in Resuscitation: Safety Not Adequately Addressed. Anesth Analg. 2011, 112: 635-645.PubMedCrossRef

go back to reference Hess JR: Massive transfusion for trauma: opportunities and risks. ISBT Science Series. 2008, 3: 197-201.CrossRef Hess JR: Massive transfusion for trauma: opportunities and risks. ISBT Science Series. 2008, 3: 197-201.CrossRef

go back to reference Wolberg AS, Meng ZH, Monroe DM: Hoffman M: A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function. J Trauma. 2004, 56: 1221-1228.PubMedCrossRef Wolberg AS, Meng ZH, Monroe DM: Hoffman M: A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function. J Trauma. 2004, 56: 1221-1228.PubMedCrossRef

go back to reference Yoshihara H, Yamamoto T, Mihara H: Changes in coagulation and fibrinolysis occurring in dogs during hypothermia. Thromb Res. 1985, 37: 503-512.PubMedCrossRef Yoshihara H, Yamamoto T, Mihara H: Changes in coagulation and fibrinolysis occurring in dogs during hypothermia. Thromb Res. 1985, 37: 503-512.PubMedCrossRef

go back to reference Hess JR, Brohi K, Dutton RP, Hauser CJ, Holcomb JB, Kluger Y, Mackway-Jones K, Parr MJ, Rizoli SB, Yukioka T, Hoyt DB, Bouillon B: The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008, 65: 748-754.PubMedCrossRef Hess JR, Brohi K, Dutton RP, Hauser CJ, Holcomb JB, Kluger Y, Mackway-Jones K, Parr MJ, Rizoli SB, Yukioka T, Hoyt DB, Bouillon B: The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008, 65: 748-754.PubMedCrossRef

go back to reference Djaldetti M, Fishman P, Bessler H, Chaimoff C: pH-induced platelet ultrastructural alterations. A possible mechanism for impaired platelet aggregation. Arch Surg. 1979, 114: 707-710.PubMed Djaldetti M, Fishman P, Bessler H, Chaimoff C: pH-induced platelet ultrastructural alterations. A possible mechanism for impaired platelet aggregation. Arch Surg. 1979, 114: 707-710.PubMed

go back to reference Martini WZ, Holcomb JB: Acidosis and coagulopathy: the differential effects on fibrinogen synthesis and breakdown in pigs. Ann Surg. 2007, 246: 831-835.PubMedCrossRef Martini WZ, Holcomb JB: Acidosis and coagulopathy: the differential effects on fibrinogen synthesis and breakdown in pigs. Ann Surg. 2007, 246: 831-835.PubMedCrossRef

go back to reference Brohi K, Singh J, Heron M, Coats T: Acute traumatic coagulopathy. J Trauma. 2003, 54: 1127-1130.PubMedCrossRef Brohi K, Singh J, Heron M, Coats T: Acute traumatic coagulopathy. J Trauma. 2003, 54: 1127-1130.PubMedCrossRef

go back to reference Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF: Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma. 2008, 64: 1211-1217.PubMedCrossRef Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF: Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma. 2008, 64: 1211-1217.PubMedCrossRef

go back to reference Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF: Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?. Ann Surg. 2007, 245: 812-818.PubMedCentralPubMedCrossRef Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF: Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?. Ann Surg. 2007, 245: 812-818.PubMedCentralPubMedCrossRef

go back to reference Brohi K, Cohen MJ, Davenport RA: Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care. 2007, 13: 680-685.PubMedCrossRef Brohi K, Cohen MJ, Davenport RA: Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care. 2007, 13: 680-685.PubMedCrossRef

go back to reference Frith D, Davenport R, Brohi K: Acute traumatic coagulopathy. Curr Opin Anaesthesiol. 2012, 25: 229-234.PubMedCrossRef Frith D, Davenport R, Brohi K: Acute traumatic coagulopathy. Curr Opin Anaesthesiol. 2012, 25: 229-234.PubMedCrossRef

go back to reference Johansson PI, Ostrowski SR: Acute coagulopathy of trauma: Balancing progressive catecholamine induced endothelial activation and damage by fluid phase anticoagulation. Med Hypotheses. 2010, 75: 564-567.PubMedCrossRef Johansson PI, Ostrowski SR: Acute coagulopathy of trauma: Balancing progressive catecholamine induced endothelial activation and damage by fluid phase anticoagulation. Med Hypotheses. 2010, 75: 564-567.PubMedCrossRef

go back to reference Johansson PI, Stissing T, Bochsen L, Ostrowski SR: Thrombelastography and tromboelastometry in assessing coagulopathy in trauma. Scand J Trauma Resusc Emerg Med. 2009, 17: 45-PubMedCentralPubMedCrossRef Johansson PI, Stissing T, Bochsen L, Ostrowski SR: Thrombelastography and tromboelastometry in assessing coagulopathy in trauma. Scand J Trauma Resusc Emerg Med. 2009, 17: 45-PubMedCentralPubMedCrossRef

go back to reference Johansson PI, Stensballe J, Rasmussen LS, Ostrowski SR: A High Admission Syndecan-1 Level, A Marker of Endothelial Glycocalyx Degradation, Is Associated With Inflammation, Protein C Depletion, Fibrinolysis, and Increased Mortality in Trauma Patients. Ann Surg. 2011, 254: 194-200.PubMedCrossRef Johansson PI, Stensballe J, Rasmussen LS, Ostrowski SR: A High Admission Syndecan-1 Level, A Marker of Endothelial Glycocalyx Degradation, Is Associated With Inflammation, Protein C Depletion, Fibrinolysis, and Increased Mortality in Trauma Patients. Ann Surg. 2011, 254: 194-200.PubMedCrossRef

go back to reference Levi M, Toh CH, Thachil J, Watson HG: Guidelines for the diagnosis and management of disseminated intravascular coagulation. Br J Haematol. 2009, 145: 24-33.PubMedCrossRef Levi M, Toh CH, Thachil J, Watson HG: Guidelines for the diagnosis and management of disseminated intravascular coagulation. Br J Haematol. 2009, 145: 24-33.PubMedCrossRef

go back to reference Hess JR, Lawson JH: The coagulopathy of trauma versus disseminated intravascular coagulation. J Trauma. 2006, 60: S12-S19.PubMedCrossRef Hess JR, Lawson JH: The coagulopathy of trauma versus disseminated intravascular coagulation. J Trauma. 2006, 60: S12-S19.PubMedCrossRef

go back to reference Johansson PI, Sørensen AM, Perner A, Welling KL, Wanscher M, Larsen CF, Ostrowski SR: Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study. Crit Care. 2011, 15: R272-PubMedCentralPubMedCrossRef Johansson PI, Sørensen AM, Perner A, Welling KL, Wanscher M, Larsen CF, Ostrowski SR: Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study. Crit Care. 2011, 15: R272-PubMedCentralPubMedCrossRef

go back to reference Gando S: Disseminated intravascular coagulation in trauma patients. Semin Thromb Hemost. 2001, 27: 585-592.PubMedCrossRef Gando S: Disseminated intravascular coagulation in trauma patients. Semin Thromb Hemost. 2001, 27: 585-592.PubMedCrossRef

go back to reference Levrat A, Gros A, Rugeri L, Inaba K, Floccard B, Negrier C, David JS: Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients. Br J Anaesth. 2008, 100: 792-797.PubMedCrossRef Levrat A, Gros A, Rugeri L, Inaba K, Floccard B, Negrier C, David JS: Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients. Br J Anaesth. 2008, 100: 792-797.PubMedCrossRef

go back to reference Carroll RC, Craft RM, Langdon RJ, Clanton CR, Snider CC, Wellons DD, Dakin PA, Lawson CM, Enderson BL, Kurek SJ: Early evaluation of acute traumatic coagulopathy by thrombelastography. Transl Res. 2009, 154: 34-39.PubMedCrossRef Carroll RC, Craft RM, Langdon RJ, Clanton CR, Snider CC, Wellons DD, Dakin PA, Lawson CM, Enderson BL, Kurek SJ: Early evaluation of acute traumatic coagulopathy by thrombelastography. Transl Res. 2009, 154: 34-39.PubMedCrossRef

go back to reference Schochl H, Frietsch T, Pavelka M, Jambor C: Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry. J Trauma. 2009, 67: 125-131.PubMedCrossRef Schochl H, Frietsch T, Pavelka M, Jambor C: Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry. J Trauma. 2009, 67: 125-131.PubMedCrossRef

go back to reference Kashuk JL, Moore EE, Sawyer M, Wohlauer M, Pezold M, Barnett C, Biffl WL, Burlew CC, Johnson JL, Sauaia A: Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma. Ann Surg. 2010, 252: 434-442.PubMed Kashuk JL, Moore EE, Sawyer M, Wohlauer M, Pezold M, Barnett C, Biffl WL, Burlew CC, Johnson JL, Sauaia A: Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma. Ann Surg. 2010, 252: 434-442.PubMed

go back to reference Budnitz DS, Lovegrove MC, Shehab N, Richards CL: Emergency hospitalizations for adverse drug events in older Americans. N Engl J Med. 2011, 365: 2002-2012.PubMedCrossRef Budnitz DS, Lovegrove MC, Shehab N, Richards CL: Emergency hospitalizations for adverse drug events in older Americans. N Engl J Med. 2011, 365: 2002-2012.PubMedCrossRef

go back to reference Wysowski DK, Nourjah P, Swartz L: Bleeding complications with warfarin use: a prevalent adverse effect resulting in regulatory action. Arch Intern Med. 2007, 167: 1414-1419.PubMedCrossRef Wysowski DK, Nourjah P, Swartz L: Bleeding complications with warfarin use: a prevalent adverse effect resulting in regulatory action. Arch Intern Med. 2007, 167: 1414-1419.PubMedCrossRef

go back to reference Oldgren J, Alings M, Darius H, Diener HC, Eikelboom J, Ezekowitz MD, Kamensky G, Reilly PA, Yang S, Yusuf S, Wallentin L, Connolly SJ: Risks for stroke, bleeding, and death in patients with atrial fibrillation receiving dabigatran or warfarin in relation to the CHADS2 score: a subgroup analysis of the RE-LY trial. Ann Intern Med. 2011, 155: 660-7. W204PubMedCrossRef Oldgren J, Alings M, Darius H, Diener HC, Eikelboom J, Ezekowitz MD, Kamensky G, Reilly PA, Yang S, Yusuf S, Wallentin L, Connolly SJ: Risks for stroke, bleeding, and death in patients with atrial fibrillation receiving dabigatran or warfarin in relation to the CHADS2 score: a subgroup analysis of the RE-LY trial. Ann Intern Med. 2011, 155: 660-7. W204PubMedCrossRef

go back to reference Huang J, Cao Y, Liao C, Wu L, Gao F: Apixaban versus enoxaparin in patients with total knee arthroplasty. A meta-analysis of randomised trials. Thromb Haemost. 2011, 105: 245-253.PubMedCrossRef Huang J, Cao Y, Liao C, Wu L, Gao F: Apixaban versus enoxaparin in patients with total knee arthroplasty. A meta-analysis of randomised trials. Thromb Haemost. 2011, 105: 245-253.PubMedCrossRef

go back to reference Duggan ST: Rivaroxaban: a review of its use for the prophylaxis of venous thromboembolism after total hip or knee replacement surgery. Am J Cardiovasc Drugs. 2012, 12: 57-72.PubMedCrossRef Duggan ST: Rivaroxaban: a review of its use for the prophylaxis of venous thromboembolism after total hip or knee replacement surgery. Am J Cardiovasc Drugs. 2012, 12: 57-72.PubMedCrossRef

go back to reference Levi M, Eerenberg ES, Kampuisen PW: Anticoagulants. Old and new. Hamostaseologie. 2011, 31: 229-235.PubMedCrossRef Levi M, Eerenberg ES, Kampuisen PW: Anticoagulants. Old and new. Hamostaseologie. 2011, 31: 229-235.PubMedCrossRef

go back to reference Cotton BA, McCarthy JJ, Holcomb JB: Acutely injured patients on dabigatran. N Engl J Med. 2011, 365: 2039-2040.PubMedCrossRef Cotton BA, McCarthy JJ, Holcomb JB: Acutely injured patients on dabigatran. N Engl J Med. 2011, 365: 2039-2040.PubMedCrossRef

go back to reference Ostrowski SR, Johansson PI: Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy. J Trauma Acute Care Surg. 2012, In press Ostrowski SR, Johansson PI: Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy. J Trauma Acute Care Surg. 2012, In press

go back to reference Becker BF, Chappell D, Bruegger D, Annecke T, Jacob M: Therapeutic strategies targeting the endothelial glycocalyx: acute deficits, but great potential. Cardiovasc Res. 2010, 87: 300-310.PubMedCrossRef Becker BF, Chappell D, Bruegger D, Annecke T, Jacob M: Therapeutic strategies targeting the endothelial glycocalyx: acute deficits, but great potential. Cardiovasc Res. 2010, 87: 300-310.PubMedCrossRef

go back to reference Rehm M, Bruegger D, Christ F, Conzen P, Thiel M, Jacob M, Chappell D, Stoeckelhuber M, Welsch U, Reichart B, Peter K, Becker BF: Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia. Circulation. 2007, 116: 1896-1906.PubMedCrossRef Rehm M, Bruegger D, Christ F, Conzen P, Thiel M, Jacob M, Chappell D, Stoeckelhuber M, Welsch U, Reichart B, Peter K, Becker BF: Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia. Circulation. 2007, 116: 1896-1906.PubMedCrossRef

go back to reference Senzolo M, Coppell J, Cholongitas E, Riddell A, Triantos CK, Perry D, Burroughs AK: The effects of glycosaminoglycans on coagulation: a thromboelastographic study. Blood Coagul Fibrinolysis. 2007, 18: 227-236.PubMedCrossRef Senzolo M, Coppell J, Cholongitas E, Riddell A, Triantos CK, Perry D, Burroughs AK: The effects of glycosaminoglycans on coagulation: a thromboelastographic study. Blood Coagul Fibrinolysis. 2007, 18: 227-236.PubMedCrossRef

go back to reference Zambruni A, Thalheimer U, Coppell J, Riddell A, Mancuso A, Leandro G, Perry D, Burroughs AK: Endogenous heparin-like activity detected by anti-Xa assay in infected cirrhotic and non-cirrhotic patients. Scand J Gastroenterol. 2004, 39: 830-836.PubMedCrossRef Zambruni A, Thalheimer U, Coppell J, Riddell A, Mancuso A, Leandro G, Perry D, Burroughs AK: Endogenous heparin-like activity detected by anti-Xa assay in infected cirrhotic and non-cirrhotic patients. Scand J Gastroenterol. 2004, 39: 830-836.PubMedCrossRef

go back to reference Agarwal S, Senzolo M, Melikian C, Burroughs A, Mallett SV: The prevalence of a heparin-like effect shown on the thromboelastograph in patients undergoing liver transplantation. Liver Transpl. 2008, 14: 855-860.PubMedCrossRef Agarwal S, Senzolo M, Melikian C, Burroughs A, Mallett SV: The prevalence of a heparin-like effect shown on the thromboelastograph in patients undergoing liver transplantation. Liver Transpl. 2008, 14: 855-860.PubMedCrossRef

go back to reference Nelson A, Berkestedt I, Schmidtchen A, Ljunggren L, Bodelsson M: Increased levels of glycosaminoglycans during septic shock: relation to mortality and the antibacterial actions of plasma. Shock. 2008, 30: 623-627.PubMedCrossRef Nelson A, Berkestedt I, Schmidtchen A, Ljunggren L, Bodelsson M: Increased levels of glycosaminoglycans during septic shock: relation to mortality and the antibacterial actions of plasma. Shock. 2008, 30: 623-627.PubMedCrossRef

go back to reference Steppan J, Hofer S, Funke B, Brenner T, Henrich M, Martin E, Weitz J, Hofmann U, Weigand MA: Sepsis and Major Abdominal Surgery Lead to Flaking of the Endothelial Glycocalix. J Surg Res. 2011, 165: 136-141.PubMedCrossRef Steppan J, Hofer S, Funke B, Brenner T, Henrich M, Martin E, Weitz J, Hofmann U, Weigand MA: Sepsis and Major Abdominal Surgery Lead to Flaking of the Endothelial Glycocalix. J Surg Res. 2011, 165: 136-141.PubMedCrossRef

go back to reference Spinler SA, Rees C: Review of prasugrel for the secondary prevention of atherothrombosis. J Manag Care Pharm. 2009, 15: 383-395.PubMed Spinler SA, Rees C: Review of prasugrel for the secondary prevention of atherothrombosis. J Manag Care Pharm. 2009, 15: 383-395.PubMed

go back to reference Roberts HR, Hoffman M, Monroe DM: A cell-based model of thrombin generation. Semin Thromb Hemost. 2006, 32 (Suppl 1): 32-38.PubMedCrossRef Roberts HR, Hoffman M, Monroe DM: A cell-based model of thrombin generation. Semin Thromb Hemost. 2006, 32 (Suppl 1): 32-38.PubMedCrossRef

go back to reference Fries D, Innerhofer P, Schobersberger W: Time for changing coagulation management in trauma-related massive bleeding. Curr Opin Anaesthesiol. 2009, 22: 267-274.PubMedCrossRef Fries D, Innerhofer P, Schobersberger W: Time for changing coagulation management in trauma-related massive bleeding. Curr Opin Anaesthesiol. 2009, 22: 267-274.PubMedCrossRef

go back to reference Murray D, Pennell B, Olson J: Variability of prothrombin time and activated partial thromboplastin time in the diagnosis of increased surgical bleeding. Transfusion. 1999, 39: 56-62.PubMedCrossRef Murray D, Pennell B, Olson J: Variability of prothrombin time and activated partial thromboplastin time in the diagnosis of increased surgical bleeding. Transfusion. 1999, 39: 56-62.PubMedCrossRef

go back to reference Segal JB, Dzik WH: Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: an evidence-based review. Transfusion. 2005, 45: 1413-1425.PubMedCrossRef Segal JB, Dzik WH: Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: an evidence-based review. Transfusion. 2005, 45: 1413-1425.PubMedCrossRef

go back to reference Salooja N, Perry DJ: Thrombelastography. Blood Coagul Fibrinolysis. 2001, 12: 327-337.PubMedCrossRef Salooja N, Perry DJ: Thrombelastography. Blood Coagul Fibrinolysis. 2001, 12: 327-337.PubMedCrossRef

go back to reference Luddington RJ: Thrombelastography/thromboelastometry. Clin Lab Haematol. 2005, 27: 81-90.PubMedCrossRef Luddington RJ: Thrombelastography/thromboelastometry. Clin Lab Haematol. 2005, 27: 81-90.PubMedCrossRef

go back to reference Ganter MT, Hofer CK: Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices. Anesth Analg. 2008, 106: 1366-1375.PubMedCrossRef Ganter MT, Hofer CK: Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices. Anesth Analg. 2008, 106: 1366-1375.PubMedCrossRef

go back to reference Plotkin AJ, Wade CE, Jenkins DH, Smith KA, Noe JC, Park MS, Perkins JG, Holcomb JB: A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries. J Trauma. 2008, 64: S64-S68.PubMedCrossRef Plotkin AJ, Wade CE, Jenkins DH, Smith KA, Noe JC, Park MS, Perkins JG, Holcomb JB: A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries. J Trauma. 2008, 64: S64-S68.PubMedCrossRef

go back to reference Park MS, Martini WZ, Dubick MA, Salinas J, Butenas S, Kheirabadi BS, Pusateri AE, Vos JA, Guymon CH, Wolf SE, Mann KG, Holcomb JB: Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time. J Trauma. 2009, 67: 266-275.PubMedCentralPubMedCrossRef Park MS, Martini WZ, Dubick MA, Salinas J, Butenas S, Kheirabadi BS, Pusateri AE, Vos JA, Guymon CH, Wolf SE, Mann KG, Holcomb JB: Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time. J Trauma. 2009, 67: 266-275.PubMedCentralPubMedCrossRef

go back to reference Ho AM, Karmakar MK, Dion PW: Are we giving enough coagulation factors during major trauma resuscitation?. Am J Surg. 2005, 190: 479-484.PubMedCrossRef Ho AM, Karmakar MK, Dion PW: Are we giving enough coagulation factors during major trauma resuscitation?. Am J Surg. 2005, 190: 479-484.PubMedCrossRef

go back to reference Ostrowski SR, Sorensen AM, Larsen CF, Johansson PI: Thrombelastography and biomarker profiles in acute coagulopathy of trauma: A prospective study. Scand J Trauma Resusc Emerg Med. 2011, 19: 64-PubMedCentralPubMedCrossRef Ostrowski SR, Sorensen AM, Larsen CF, Johansson PI: Thrombelastography and biomarker profiles in acute coagulopathy of trauma: A prospective study. Scand J Trauma Resusc Emerg Med. 2011, 19: 64-PubMedCentralPubMedCrossRef

go back to reference Rugeri L, Levrat A, David JS, Delecroix E, Floccard B, Gros A, Allaouchiche B, Negrier C: Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography. J Thromb Haemost. 2007, 5: 289-295.PubMedCrossRef Rugeri L, Levrat A, David JS, Delecroix E, Floccard B, Gros A, Allaouchiche B, Negrier C: Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography. J Thromb Haemost. 2007, 5: 289-295.PubMedCrossRef

go back to reference Gaarder C, Naess PA, Frischknecht CE, Hakala P, Handolin L, Heier HE, Ivancev K, Johansson P, Leppaniemi A, Lippert F, Lossius HM, Opdahl H, Pillgram-Larsen J, Roise O, Skaga NO, Soreide E, Stensballe J, Tonnessen E, Tottermann A, Ortenwall P, Ostlund A: Scandinavian Guidelines–"The massively bleeding patient". Scand J Surg. 2008, 97: 15-36.PubMed Gaarder C, Naess PA, Frischknecht CE, Hakala P, Handolin L, Heier HE, Ivancev K, Johansson P, Leppaniemi A, Lippert F, Lossius HM, Opdahl H, Pillgram-Larsen J, Roise O, Skaga NO, Soreide E, Stensballe J, Tonnessen E, Tottermann A, Ortenwall P, Ostlund A: Scandinavian Guidelines–"The massively bleeding patient". Scand J Surg. 2008, 97: 15-36.PubMed

go back to reference Rossaint R, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernandez-Mondejar E, Hunt BJ, Komadina R, Nardi G, Neugebauer E, Ozier Y, Riddez L, Schultz A, Stahel PF, Vincent JL, Spahn DR: Task Force for Advanced Bleeding Care in Trauma. Management of bleeding following major trauma: an updated European guideline. Crit Care. 2010, 14: R52-PubMedCentralPubMedCrossRef Rossaint R, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernandez-Mondejar E, Hunt BJ, Komadina R, Nardi G, Neugebauer E, Ozier Y, Riddez L, Schultz A, Stahel PF, Vincent JL, Spahn DR: Task Force for Advanced Bleeding Care in Trauma. Management of bleeding following major trauma: an updated European guideline. Crit Care. 2010, 14: R52-PubMedCentralPubMedCrossRef

go back to reference Hess JR, Johansson PI, Holcomb JB: Massive transfusion and transfusion therapy in trauma. Transfusion Therapy: Clinical Principles and Practice (3rd Edition). 2011, Mintz PD (Ed.). AABB Press 2011, Bethesda, MD, USA, 305-321. Hess JR, Johansson PI, Holcomb JB: Massive transfusion and transfusion therapy in trauma. Transfusion Therapy: Clinical Principles and Practice (3rd Edition). 2011, Mintz PD (Ed.). AABB Press 2011, Bethesda, MD, USA, 305-321.

go back to reference Hayward CP, Moffat KA, Raby A, Israels S, Plumhoff E, Flynn G, Zehnder JL: Development of North American consensus guidelines for medical laboratories that perform and interpret platelet function testing using light transmission aggregometry. Am J Clin Pathol. 2010, 134: 955-963.PubMedCrossRef Hayward CP, Moffat KA, Raby A, Israels S, Plumhoff E, Flynn G, Zehnder JL: Development of North American consensus guidelines for medical laboratories that perform and interpret platelet function testing using light transmission aggregometry. Am J Clin Pathol. 2010, 134: 955-963.PubMedCrossRef

go back to reference Johansson PI, Stensballe J: Effect of Haemostatic Control Resuscitation on mortality in massively bleeding patients: a before and after study. Vox Sang. 2009, 96: 111-118.PubMedCentralPubMedCrossRef Johansson PI, Stensballe J: Effect of Haemostatic Control Resuscitation on mortality in massively bleeding patients: a before and after study. Vox Sang. 2009, 96: 111-118.PubMedCentralPubMedCrossRef

go back to reference Afshari A, Wikkelso A, Brok J, Moller AM, Wetterslev J: Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion. Cochrane Database Syst Rev. 2011, 3: CD007871.:CD007871 Afshari A, Wikkelso A, Brok J, Moller AM, Wetterslev J: Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion. Cochrane Database Syst Rev. 2011, 3: CD007871.:CD007871

go back to reference Uijttewaal WS, Nijhof EJ, Bronkhorst PJ, Den Hartog E, Heethaar RM: Near-wall excess of platelets induced by lateral migration of erythrocytes in flowing blood. Am J Physiol. 1993, 264: H1239-H1244.PubMed Uijttewaal WS, Nijhof EJ, Bronkhorst PJ, Den Hartog E, Heethaar RM: Near-wall excess of platelets induced by lateral migration of erythrocytes in flowing blood. Am J Physiol. 1993, 264: H1239-H1244.PubMed

go back to reference Peyrou V, Lormeau JC, Herault JP, Gaich C, Pfliegger AM, Herbert JM: Contribution of erythrocytes to thrombin generation in whole blood. Thromb Haemost. 1999, 81: 400-406.PubMed Peyrou V, Lormeau JC, Herault JP, Gaich C, Pfliegger AM, Herbert JM: Contribution of erythrocytes to thrombin generation in whole blood. Thromb Haemost. 1999, 81: 400-406.PubMed

go back to reference Joist JH, Bauman JE, Sutera SP: Platelet adhesion and aggregation in pulsatile shear flow: effects of red blood cells. Thromb Res. 1998, 92: S47-S52.PubMedCrossRef Joist JH, Bauman JE, Sutera SP: Platelet adhesion and aggregation in pulsatile shear flow: effects of red blood cells. Thromb Res. 1998, 92: S47-S52.PubMedCrossRef

go back to reference Valles J, Santos MT, Aznar J, Marcus AJ, Martinez-Sales V, Portoles M, Broekman MJ, Safier LB: Erythrocytes metabolically enhance collagen-induced platelet responsiveness via increased thromboxane production, adenosine diphosphate release, and recruitment. Blood. 1991, 78: 154-162.PubMed Valles J, Santos MT, Aznar J, Marcus AJ, Martinez-Sales V, Portoles M, Broekman MJ, Safier LB: Erythrocytes metabolically enhance collagen-induced platelet responsiveness via increased thromboxane production, adenosine diphosphate release, and recruitment. Blood. 1991, 78: 154-162.PubMed

go back to reference Monroe DM, Hoffman M: What does it take to make the perfect clot?. Arterioscler Thromb Vasc Biol. 2006, 26: 41-48.PubMedCrossRef Monroe DM, Hoffman M: What does it take to make the perfect clot?. Arterioscler Thromb Vasc Biol. 2006, 26: 41-48.PubMedCrossRef

go back to reference Hardy JF, de Moerloose P, Samama CM: Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Can J Anaesth. 2006, 53: S40-S58.PubMedCrossRef Hardy JF, de Moerloose P, Samama CM: Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Can J Anaesth. 2006, 53: S40-S58.PubMedCrossRef

go back to reference Snyder CW, Weinberg JA, McGwin G, Melton SM, George RL, Reiff DA, Cross JM, Hubbard-Brown J, Rue LW, Kerby JD: The relationship of blood product ratio to mortality: survival benefit or survival bias?. J Trauma. 2009, 66: 358-362.PubMedCrossRef Snyder CW, Weinberg JA, McGwin G, Melton SM, George RL, Reiff DA, Cross JM, Hubbard-Brown J, Rue LW, Kerby JD: The relationship of blood product ratio to mortality: survival benefit or survival bias?. J Trauma. 2009, 66: 358-362.PubMedCrossRef

go back to reference Duchesne JC, Hunt JP, Wahl G, Marr AB, Wang YZ, Weintraub SE, Wright MJ, McSwain NE: Review of current blood transfusions strategies in a mature level I trauma center: were we wrong for the last 60 years?. J Trauma. 2008, 65: 272-276.PubMedCrossRef Duchesne JC, Hunt JP, Wahl G, Marr AB, Wang YZ, Weintraub SE, Wright MJ, McSwain NE: Review of current blood transfusions strategies in a mature level I trauma center: were we wrong for the last 60 years?. J Trauma. 2008, 65: 272-276.PubMedCrossRef

go back to reference Maegele M, Lefering R, Paffrath T, Tjardes T, Simanski C, Bouillon B: Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft fur Unfallchirurgie. Vox Sang. 2008, 95: 112-119.PubMedCrossRef Maegele M, Lefering R, Paffrath T, Tjardes T, Simanski C, Bouillon B: Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft fur Unfallchirurgie. Vox Sang. 2008, 95: 112-119.PubMedCrossRef

go back to reference Stinger HK, Spinella PC, Perkins JG, Grathwohl KW, Salinas J, Martini WZ, Hess JR, Dubick MA, Simon CD, Beekley AC, Wolf SE, Wade CE, Holcomb JB: The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital. J Trauma. 2008, 64: S79-S85.PubMedCrossRef Stinger HK, Spinella PC, Perkins JG, Grathwohl KW, Salinas J, Martini WZ, Hess JR, Dubick MA, Simon CD, Beekley AC, Wolf SE, Wade CE, Holcomb JB: The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital. J Trauma. 2008, 64: S79-S85.PubMedCrossRef

go back to reference Kashuk JL, Moore EE, Johnson JL, Haenel J, Wilson M, Moore JB, Cothren CC, Biffl WL, Banerjee A, Sauaia A: Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red blood cells the answer?. J Trauma. 2008, 65: 261-270.PubMedCrossRef Kashuk JL, Moore EE, Johnson JL, Haenel J, Wilson M, Moore JB, Cothren CC, Biffl WL, Banerjee A, Sauaia A: Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red blood cells the answer?. J Trauma. 2008, 65: 261-270.PubMedCrossRef

go back to reference Teixeira PG, Inaba K, Shulman I, Salim A, Demetriades D, Brown C, Browder T, Green D, Rhee P: Impact of plasma transfusion in massively transfused trauma patients. J Trauma. 2009, 66: 693-697.PubMedCrossRef Teixeira PG, Inaba K, Shulman I, Salim A, Demetriades D, Brown C, Browder T, Green D, Rhee P: Impact of plasma transfusion in massively transfused trauma patients. J Trauma. 2009, 66: 693-697.PubMedCrossRef

go back to reference Holcomb JB, Wade CE, Michalek JE, Chisholm GB, Zarzabal LA, Schreiber MA, Gonzalez EA, Pomper GJ, Perkins JG, Spinella PC, Williams KL, Park MS: Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg. 2008, 248: 447-458.PubMed Holcomb JB, Wade CE, Michalek JE, Chisholm GB, Zarzabal LA, Schreiber MA, Gonzalez EA, Pomper GJ, Perkins JG, Spinella PC, Williams KL, Park MS: Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg. 2008, 248: 447-458.PubMed

go back to reference Zink KA, Sambasivan CN, Holcomb JB, Chisholm G, Schreiber MA: A high ratio of plasma and platelets to packed red blood cells in the first 6 hours of massive transfusion improves outcomes in a large multicenter study. Am J Surg. 2009, 197: 565-570.PubMedCrossRef Zink KA, Sambasivan CN, Holcomb JB, Chisholm G, Schreiber MA: A high ratio of plasma and platelets to packed red blood cells in the first 6 hours of massive transfusion improves outcomes in a large multicenter study. Am J Surg. 2009, 197: 565-570.PubMedCrossRef

go back to reference Sperry JL, Ochoa JB, Gunn SR, Alarcon LH, Minei JP, Cuschieri J, Rosengart MR, Maier RV, Billiar TR, Peitzman AB, Moore EE: An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion. J Trauma. 2008, 65: 986-993.PubMedCrossRef Sperry JL, Ochoa JB, Gunn SR, Alarcon LH, Minei JP, Cuschieri J, Rosengart MR, Maier RV, Billiar TR, Peitzman AB, Moore EE: An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion. J Trauma. 2008, 65: 986-993.PubMedCrossRef

go back to reference Murad MH, Stubbs JR, Gandhi MJ, Wang AT, Paul A, Erwin PJ, Montori VM, Roback JD: The effect of plasma transfusion on morbidity and mortality: a systematic review and meta-analysis. Transfusion. 2010, 50: 1370-1383.PubMedCrossRef Murad MH, Stubbs JR, Gandhi MJ, Wang AT, Paul A, Erwin PJ, Montori VM, Roback JD: The effect of plasma transfusion on morbidity and mortality: a systematic review and meta-analysis. Transfusion. 2010, 50: 1370-1383.PubMedCrossRef

go back to reference Johansson PI, Oliveri R, Ostrowski SR: Hemostatic resuscitation with plasma and platelets in trauma. A meta-analysis. J Emerg Trauma Shock. 2012, 5: 120-125.PubMedCrossRef Johansson PI, Oliveri R, Ostrowski SR: Hemostatic resuscitation with plasma and platelets in trauma. A meta-analysis. J Emerg Trauma Shock. 2012, 5: 120-125.PubMedCrossRef

go back to reference Adam DJ, Haggart PC, Ludlam CA, Bradbury AW: von Willebrand factor and platelet count in ruptured abdominal aortic aneurysm repair. Eur J Vasc Endovasc Surg. 2003, 26: 412-417.PubMedCrossRef Adam DJ, Haggart PC, Ludlam CA, Bradbury AW: von Willebrand factor and platelet count in ruptured abdominal aortic aneurysm repair. Eur J Vasc Endovasc Surg. 2003, 26: 412-417.PubMedCrossRef

go back to reference Johansson PI, Stensballe J, Rosenberg I, Hilslov TL, Jorgensen L, Secher NH: Proactive administration of platelets and plasma for patients with a ruptured abdominal aortic aneurysm: evaluating a change in transfusion practice. Transfusion. 2007, 47: 593-598.PubMedCrossRef Johansson PI, Stensballe J, Rosenberg I, Hilslov TL, Jorgensen L, Secher NH: Proactive administration of platelets and plasma for patients with a ruptured abdominal aortic aneurysm: evaluating a change in transfusion practice. Transfusion. 2007, 47: 593-598.PubMedCrossRef

go back to reference Inaba K, Branco BC, Rhee P, Blackbourne LH, Holcomb JB, Teixeira PG, Shulman I, Nelson J, Demetriades D: Impact of plasma transfusion in trauma patients who do not require massive transfusion. J Am Coll Surg. 2010, 210: 957-965.PubMedCrossRef Inaba K, Branco BC, Rhee P, Blackbourne LH, Holcomb JB, Teixeira PG, Shulman I, Nelson J, Demetriades D: Impact of plasma transfusion in trauma patients who do not require massive transfusion. J Am Coll Surg. 2010, 210: 957-965.PubMedCrossRef

go back to reference Brown LM, Call MS, Margaret KM, Cohen MJ, Holcomb JB, Wade CE, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Hess JR, Duchesne JC, McSwain NE, Muskat P, Johannigamn J, Cryer HM, Tillou A, Pittet JF, De Moya MA, Schreiber MA, Tieu B, Brundage S, Napolitano LM, Brunsvold M, Brunsvold M, Beilman G, Peitzman AB, Zenait MS, Sperry J, Alarcon L, Croce MA, Minei JP, Kozar R, Gonzalez EA, Stewart RM, Cohn SM, Mickalek JE, Bulger EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Miller P, Pomper GJ, Marin B: A normal platelet count may not be enough: the impact of admission platelet count on mortality and transfusion in severely injured trauma patients. J Trauma. 2011, 71: S337-S342.PubMedCentralPubMedCrossRef Brown LM, Call MS, Margaret KM, Cohen MJ, Holcomb JB, Wade CE, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Hess JR, Duchesne JC, McSwain NE, Muskat P, Johannigamn J, Cryer HM, Tillou A, Pittet JF, De Moya MA, Schreiber MA, Tieu B, Brundage S, Napolitano LM, Brunsvold M, Brunsvold M, Beilman G, Peitzman AB, Zenait MS, Sperry J, Alarcon L, Croce MA, Minei JP, Kozar R, Gonzalez EA, Stewart RM, Cohn SM, Mickalek JE, Bulger EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Miller P, Pomper GJ, Marin B: A normal platelet count may not be enough: the impact of admission platelet count on mortality and transfusion in severely injured trauma patients. J Trauma. 2011, 71: S337-S342.PubMedCentralPubMedCrossRef

go back to reference Ho AM, Dion PW, Yeung JH, Joynt GM, Lee A, Ng CS, Chang A, So FL, Cheung CW: Simulation of survivorship bias in observational studies on plasma to red blood cell ratios in massive transfusion for trauma. Br J Surg. 2012, 99 (Suppl 1): 132-9. 10.1002/bjs.7732.:132-139.PubMedCrossRef Ho AM, Dion PW, Yeung JH, Joynt GM, Lee A, Ng CS, Chang A, So FL, Cheung CW: Simulation of survivorship bias in observational studies on plasma to red blood cell ratios in massive transfusion for trauma. Br J Surg. 2012, 99 (Suppl 1): 132-9. 10.1002/bjs.7732.:132-139.PubMedCrossRef

go back to reference Cotton BA, Gunter OL, Isbell J, Au BK, Robertson AM, Morris JA: St Jacques P, Young PP: Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization. J Trauma. 2008, 64: 1177-1182.PubMedCrossRef Cotton BA, Gunter OL, Isbell J, Au BK, Robertson AM, Morris JA: St Jacques P, Young PP: Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization. J Trauma. 2008, 64: 1177-1182.PubMedCrossRef

go back to reference Cotton BA, Au BK, Nunez TC, Gunter OL, Robertson AM, Young PP: Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications. J Trauma. 2009, 66: 41-48.PubMedCrossRef Cotton BA, Au BK, Nunez TC, Gunter OL, Robertson AM, Young PP: Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications. J Trauma. 2009, 66: 41-48.PubMedCrossRef

go back to reference Duchesne JC, Kimonis K, Marr AB, Rennie KV, Wahl G, Wells JE, Islam TM, Meade P, Stuke L, Barbeau JM, Hunt JP, Baker CC, McSwain NE: Damage control resuscitation in combination with damage control laparotomy: a survival advantage. J Trauma. 2010, 69: 46-52.PubMedCrossRef Duchesne JC, Kimonis K, Marr AB, Rennie KV, Wahl G, Wells JE, Islam TM, Meade P, Stuke L, Barbeau JM, Hunt JP, Baker CC, McSwain NE: Damage control resuscitation in combination with damage control laparotomy: a survival advantage. J Trauma. 2010, 69: 46-52.PubMedCrossRef

go back to reference Spinella PC, Perkins JG, Grathwohl KW, Beekley AC, Holcomb JB: Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries. J Trauma. 2009, 66: S69-S76.PubMedCentralPubMedCrossRef Spinella PC, Perkins JG, Grathwohl KW, Beekley AC, Holcomb JB: Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries. J Trauma. 2009, 66: S69-S76.PubMedCentralPubMedCrossRef

go back to reference Vamvakas EC, Blajchman MA: Transfusion-related mortality: the ongoing risks of allogeneic blood transfusion and the available strategies for their prevention. Blood. 2009, 113: 3406-3417.PubMedCrossRef Vamvakas EC, Blajchman MA: Transfusion-related mortality: the ongoing risks of allogeneic blood transfusion and the available strategies for their prevention. Blood. 2009, 113: 3406-3417.PubMedCrossRef

go back to reference Porte RJ, Leebeek FW: Pharmacological strategies to decrease transfusion requirements in patients undergoing surgery. Drugs. 2002, 62: 2193-2211.PubMedCrossRef Porte RJ, Leebeek FW: Pharmacological strategies to decrease transfusion requirements in patients undergoing surgery. Drugs. 2002, 62: 2193-2211.PubMedCrossRef

go back to reference Henry DA, Carless PA, Moxey AJ, O'Connell D, Stokes BJ, McClelland B, Laupacis A, Fergusson D: Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev. 2011, 16: CD001886 Henry DA, Carless PA, Moxey AJ, O'Connell D, Stokes BJ, McClelland B, Laupacis A, Fergusson D: Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev. 2011, 16: CD001886

go back to reference Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejia-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S, CRASH-2 Trial collaborators: Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010, 376: 23-32.PubMedCrossRef Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejia-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S, CRASH-2 Trial collaborators: Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010, 376: 23-32.PubMedCrossRef

go back to reference Hedner U: Factor VIIa and its potential therapeutic use in bleeding-associated pathologies. Thromb Haemost. 2008, 100: 557-562.PubMed Hedner U: Factor VIIa and its potential therapeutic use in bleeding-associated pathologies. Thromb Haemost. 2008, 100: 557-562.PubMed

go back to reference Johansson PI, Ostrowski SR: Evidence supporting the use of recombinant activated factor vii in congenital bleeding disorders. Drug Design Dev Ther. 2010, 4: 107-116.CrossRef Johansson PI, Ostrowski SR: Evidence supporting the use of recombinant activated factor vii in congenital bleeding disorders. Drug Design Dev Ther. 2010, 4: 107-116.CrossRef

go back to reference Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, Holcomb JB, Leppaniemi A, Parr M, Vincent JL, Tortella BJ, Dimsits J, Bouillon B: Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma. 2010, 69: 489-500.PubMedCrossRef Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, Holcomb JB, Leppaniemi A, Parr M, Vincent JL, Tortella BJ, Dimsits J, Bouillon B: Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma. 2010, 69: 489-500.PubMedCrossRef

go back to reference Kenet G, Walden R, Eldad A, Martinowitz U: Treatment of traumatic bleeding with recombinant factor VIIa. Lancet. 1879, 1999: 354- Kenet G, Walden R, Eldad A, Martinowitz U: Treatment of traumatic bleeding with recombinant factor VIIa. Lancet. 1879, 1999: 354-

go back to reference Levi M, Levy JH, Andersen HF, Truloff D: Safety of Recombinant Activated Factor VII in Randomized Clinical Trials. N Engl J Med. 2010, 363: 1791-1800.PubMedCrossRef Levi M, Levy JH, Andersen HF, Truloff D: Safety of Recombinant Activated Factor VII in Randomized Clinical Trials. N Engl J Med. 2010, 363: 1791-1800.PubMedCrossRef

go back to reference Hiippala ST, Myllyla GJ, Vahtera EM: Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesth Analg. 1995, 81: 360-365.PubMed Hiippala ST, Myllyla GJ, Vahtera EM: Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesth Analg. 1995, 81: 360-365.PubMed

go back to reference Nielsen VG, Cohen BM, Cohen E: Effects of coagulation factor deficiency on plasma coagulation kinetics determined via thrombelastography: critical roles of fibrinogen and factors II, VII, X and XII. Acta Anaesthesiol Scand. 2005, 49: 222-231.PubMedCrossRef Nielsen VG, Cohen BM, Cohen E: Effects of coagulation factor deficiency on plasma coagulation kinetics determined via thrombelastography: critical roles of fibrinogen and factors II, VII, X and XII. Acta Anaesthesiol Scand. 2005, 49: 222-231.PubMedCrossRef

go back to reference Fenger-Eriksen C, Jensen TM, Kristensen BS, Jensen KM, Tonnesen E, Ingerslev J, Sorensen B: Fibrinogen substitution improves whole blood clot firmness after dilution with hydroxyethyl starch in bleeding patients undergoing radical cystectomy: a randomized, placebo-controlled clinical trial. J Thromb Haemost. 2009, 7: 795-802.PubMedCrossRef Fenger-Eriksen C, Jensen TM, Kristensen BS, Jensen KM, Tonnesen E, Ingerslev J, Sorensen B: Fibrinogen substitution improves whole blood clot firmness after dilution with hydroxyethyl starch in bleeding patients undergoing radical cystectomy: a randomized, placebo-controlled clinical trial. J Thromb Haemost. 2009, 7: 795-802.PubMedCrossRef

go back to reference Warmuth M, Mad P, Wild C: Systematic review of the efficacy and safety of fibrinogen concentrate substitution in adults. Acta Anaesthesiol Scand. 2011, 56: 539-5348.PubMedCrossRef Warmuth M, Mad P, Wild C: Systematic review of the efficacy and safety of fibrinogen concentrate substitution in adults. Acta Anaesthesiol Scand. 2011, 56: 539-5348.PubMedCrossRef

go back to reference Pabinger-Fasching I: Warfarin-reversal: results of a phase III study with pasteurised, nanofiltrated prothrombin complex concentrate. Thromb Res. 2008, 122 (Suppl 2): S19-22. S19-S22PubMedCrossRef Pabinger-Fasching I: Warfarin-reversal: results of a phase III study with pasteurised, nanofiltrated prothrombin complex concentrate. Thromb Res. 2008, 122 (Suppl 2): S19-22. S19-S22PubMedCrossRef

go back to reference Carvalho MC, Rodrigues AG, Conceicao LM, Galvao ML, Ribeiro LC: Prothrombin complex concentrate (Octaplex): a Portuguese experience in 1152 patients. Blood Coagul Fibrinolysis. 2012, 23: 222-228.PubMedCrossRef Carvalho MC, Rodrigues AG, Conceicao LM, Galvao ML, Ribeiro LC: Prothrombin complex concentrate (Octaplex): a Portuguese experience in 1152 patients. Blood Coagul Fibrinolysis. 2012, 23: 222-228.PubMedCrossRef

go back to reference Lorand L: Factor III: structure, activation, and interactions with fibrinogen and fibrin. Ann N Y Acad Sci. 2001, 936: 291-311.PubMedCrossRef Lorand L: Factor III: structure, activation, and interactions with fibrinogen and fibrin. Ann N Y Acad Sci. 2001, 936: 291-311.PubMedCrossRef

go back to reference Wettstein P, Haeberli A, Stutz M, Rohner M, Corbetta C, Gabi K, Schnider T, Korte W: Decreased factor XIII availability for thrombin and early loss of clot firmness in patients with unexplained intraoperative bleeding. Anesth Analg. 2004, 99: 1564-1569.PubMedCrossRef Wettstein P, Haeberli A, Stutz M, Rohner M, Corbetta C, Gabi K, Schnider T, Korte W: Decreased factor XIII availability for thrombin and early loss of clot firmness in patients with unexplained intraoperative bleeding. Anesth Analg. 2004, 99: 1564-1569.PubMedCrossRef

go back to reference Chandler WL, Patel MA, Gravelle L, Soltow LO, Lewis K, Bishop PD, Spiess BD: Factor XIIIA and clot strength after cardiopulmonary bypass. Blood Coagul Fibrinolysis. 2001, 12: 101-108.PubMedCrossRef Chandler WL, Patel MA, Gravelle L, Soltow LO, Lewis K, Bishop PD, Spiess BD: Factor XIIIA and clot strength after cardiopulmonary bypass. Blood Coagul Fibrinolysis. 2001, 12: 101-108.PubMedCrossRef

go back to reference Sorensen B, Fries D: Emerging treatment strategies for trauma-induced coagulopathy. Br J Surg. 2012, 99 (Suppl 1): 40-50. 10.1002/bjs.7770.:40-50.PubMedCrossRef Sorensen B, Fries D: Emerging treatment strategies for trauma-induced coagulopathy. Br J Surg. 2012, 99 (Suppl 1): 40-50. 10.1002/bjs.7770.:40-50.PubMedCrossRef

go back to reference Johansson PI: Emerging treatment strategies for trauma-induced coagulopathy. Br J Surg. 2012, 99 (Suppl 1): 40-50. http://dx.doi.org/10.1002/bjs.7792.:51 Br J Surg 2012, 99 Suppl 1:51 Johansson PI: Emerging treatment strategies for trauma-induced coagulopathy. Br J Surg. 2012, 99 (Suppl 1): 40-50. http://​dx.​doi.​org/​10.​1002/​bjs.​7792.​:​51 Br J Surg 2012, 99 Suppl 1:51

go back to reference Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Åneman A, Madsen KR, Møller MH, Elkjær JM, Poulsen LM, Bendtsen A, Winding R, Steensen M, Berezowicz P, Søe-Jensen P, Bestle M, Strand K, Wiis J, White JO, Thornberg KJ, Quist L, Nielsen J, Andersen LH, Holst LB, Thormar K K, Kjældgaard AL, Fabritius ML, Mondrup F, Pott FC, Møller TP, Winkel P, Wetterslev J, 6S Trial Group; Scandinavian Critical Care Trials Group. : Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis. N Engl J Med. 2012, 12: 101-108. Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Åneman A, Madsen KR, Møller MH, Elkjær JM, Poulsen LM, Bendtsen A, Winding R, Steensen M, Berezowicz P, Søe-Jensen P, Bestle M, Strand K, Wiis J, White JO, Thornberg KJ, Quist L, Nielsen J, Andersen LH, Holst LB, Thormar K K, Kjældgaard AL, Fabritius ML, Mondrup F, Pott FC, Møller TP, Winkel P, Wetterslev J, 6S Trial Group; Scandinavian Critical Care Trials Group. : Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis. N Engl J Med. 2012, 12: 101-108.