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Published in: Molecular Neurodegeneration 1/2013

Open Access 01-12-2013 | Research article

Heart fatty acid binding protein and Aβ-associated Alzheimer’s neurodegeneration

Authors: Rahul S Desikan, Wesley K Thompson, Dominic Holland, Christopher P Hess, James B Brewer, Henrik Zetterberg, Kaj Blennow, Ole A Andreassen, Linda K McEvoy, Bradley T Hyman, Anders M Dale, For the Alzheimer’s Disease Neuroimaging Initiative

Published in: Molecular Neurodegeneration | Issue 1/2013

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Abstract

Background

Epidemiological and molecular findings suggest a relationship between Alzheimer’s disease (AD) and dyslipidemia, although the nature of this association is not well understood.

Results

Using linear mixed effects models, we investigated the relationship between CSF levels of heart fatty acid binding protein (HFABP), a lipid binding protein involved with fatty acid metabolism and lipid transport, amyloid-β (Aβ), phospho-tau, and longitudinal MRI-based measures of brain atrophy among 295 non-demented and demented older individuals. Across all participants, we found a significant association of CSF HFABP with longitudinal atrophy of the entorhinal cortex and other AD-vulnerable neuroanatomic regions. However, we found that the relationship between CSF HABP and brain atrophy was significant only among those with low CSF Aβ1–42 and occurred irrespective of phospho-tau181p status.

Conclusions

Our findings indicate that Aβ-associated volume loss occurs in the presence of elevated HFABP irrespective of phospho-tau. This implicates a potentially important role for fatty acid binding proteins in Alzheimer’s disease neurodegeneration.
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Metadata
Title
Heart fatty acid binding protein and Aβ-associated Alzheimer’s neurodegeneration
Authors
Rahul S Desikan
Wesley K Thompson
Dominic Holland
Christopher P Hess
James B Brewer
Henrik Zetterberg
Kaj Blennow
Ole A Andreassen
Linda K McEvoy
Bradley T Hyman
Anders M Dale
For the Alzheimer’s Disease Neuroimaging Initiative
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Molecular Neurodegeneration / Issue 1/2013
Electronic ISSN: 1750-1326
DOI
https://doi.org/10.1186/1750-1326-8-39

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