Top

Published in:

Open Access 01-12-2013 | Research

Relationship between radiation pneumonitis and organizing pneumonia after radiotherapy for breast cancer

Authors: Yumi Oie, Yasunori Saito, Masanao Kato, Fumitaka Ito, Hidekazu Hattori, Hiroshi Toyama, Hidetoshi Kobayashi, Kazuhiro Katada

Published in: Radiation Oncology | Issue 1/2013

Abstract

Background

Radiation pneumonitis (RP) and organizing pneumonia (OP) are the two main types of lung damage that can occur after lung irradiation. The goal of this study was to evaluate the relationship between RP and OP after irradiation for breast cancer.

Methods

Four hundred and twenty-eight patients who underwent radiotherapy for breast cancer were identified. The whole breast was irradiated with two tangential photon beams. Chest computed tomography (CT) scan were performed when patients showed any symptoms that were suspicious for pneumonitis.

Results

Five patients (1.2%) were diagnosed with OP. All five patients showed ground glass opacities and consolidation of the border of the lesion of RP in the radiation fields. Infiltration of OP spread from the site of RP to the hilum of the ipsilateral lung. Between RP and OP, a free region space (FRS) could be detected.

Conclusions

OP is closely related to RP. All OP lesions developed near the site of RP.

Available only for authorised users

Darby S, McGale P, Correa C, Taylor C, Arriagada R, Clarke M, Cutter D, Davies C, Ewertz M, Godwin J: Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet 2011, 378: 1707-1716.CrossRefPubMed

Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans E, Godwin J, Gray R, Hicks C, James S: Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005, 366: 2087-2106.CrossRefPubMed

Nozaki M, Kagami Y, Mitsumori M, Hiraoka M: A multicenter investigation of late adverse events in Japanese women treated with breast-conserving surgery plus conventional fractionated whole-breast radiation therapy. Jpn J Clin Oncol 2012, 42: 522-527. 10.1093/jjco/hys050CrossRefPubMed

Crestani B, Valeyre D, Roden S, Wallaert B, Dalphin JC, Cordier JF: Bronchiolitis obliterans organizing pneumonia syndrome primed by radiation therapy to the breast. The Groupe d’Etudes et de Recherche sur les Maladies Orphelines Pulmonaires (GERM“O”P). Am J Respir Crit Care Med 1998, 158: 1929-1935.CrossRefPubMed

Jenkins P, Welsh A: Computed tomography appearance of early radiation injury to the lung: correlation with clinical and dosimetric factors. Int J Radiat Oncol Biol Phys 2011, 81: 97-103. 10.1016/j.ijrobp.2010.05.017CrossRefPubMed

Ogo E, Komaki R, Fujimoto K, Uchida M, Abe T, Nakamura K, Mitsumori M, Sekiguchi K, Kaneyasu Y, Hayabuchi N: A survey of radiation-induced bronchiolitis obliterans organizing pneumonia syndrome after breast-conserving therapy in Japan. Int J Radiat Oncol Biol Phys 2008, 71: 123-131. 10.1016/j.ijrobp.2007.09.003CrossRefPubMed

Takigawa N, Segawa Y, Saeki T, Kataoka M, Ida M, Kishino D, Fujiwara K, Ohsumi S, Eguchi K, Takashima S: Bronchiolitis obliterans organizing pneumonia syndrome in breast-conserving therapy for early breast cancer: radiation-induced lung toxicity. Int J Radiat Oncol Biol Phys 2000, 48: 751-755. 10.1016/S0360-3016(00)00654-4CrossRefPubMed

Katayama N, Sato S, Katsui K, Takemoto M, Tsuda T, Yoshida A, Morito T, Nakagawa T, Mizuta A, Waki T: Analysis of factors associated with radiation-induced bronchiolitis obliterans organizing pneumonia syndrome after breast-conserving therapy. Int J Radiat Oncol Biol Phys 2009, 73: 1049-1054. 10.1016/j.ijrobp.2008.05.050CrossRefPubMed

Kubo A, Osaki K, Kawanaka T, Furutani S, Ikushima H, Nishitani H: Risk factors for radiation pneumonitis caused by whole breast irradiation following breast-conserving surgery. J Med Invest: JMI 2009, 56: 99-110. 10.2152/jmi.56.99CrossRefPubMed

10.

Kano A, Ujita M, Kobayashi M, Sunakawa Y, Shirahama J, Harada T, Kanehira C, Fukuda K: Radiographic and CT features of radiation-induced organizing pneumonia syndrome after breast-conserving therapy. Jpn J Radiol 2012, 30: 128-136. 10.1007/s11604-011-0024-9CrossRefPubMed

11.

Ogo E, Komaki R, Abe T, Uchida M, Fujimoto K, Suzuki G, Tsuji C, Suefuji H, Etou H, Hattori C: The clinical characteristics and non-steroidal treatment for radiation-induced bronchiolitis obliterans organizing pneumonia syndrome after breast-conserving therapy. Radiother oncol: J European Society Therapeutic Radiology Oncol 2010, 97: 95-100. 10.1016/j.radonc.2010.02.032CrossRef

12.

Tsujino K, Hirota S, Endo M, Obayashi K, Kotani Y, Satouchi M, Kado T, Takada Y: Predictive value of dose-volume histogram parameters for predicting radiation pneumonitis after concurrent chemoradiation for lung cancer. Int J Radiat Oncol Biol Phys 2003, 55: 110-115. 10.1016/S0360-3016(02)03807-5CrossRefPubMed

13.

Inoue A, Kunitoh H, Sekine I, Sumi M, Tokuuye K, Saijo N: Radiation pneumonitis in lung cancer patients: a retrospective study of risk factors and the long-term prognosis. Int J Radiat Oncol Biol Phys 2001, 49: 649-655. 10.1016/S0360-3016(00)00783-5CrossRefPubMed

14.

Yamashita H, Nakagawa K, Nakamura N, Koyanagi H, Tago M, Igaki H, Shiraishi K, Sasano N, Ohtomo K: Exceptionally high incidence of symptomatic grade 2–5 radiation pneumonitis after stereotactic radiation therapy for lung tumors. Radiat Oncol 2007, 2: 21. 10.1186/1748-717X-2-21CrossRefPubMedPubMedCentral

15.

Asakura H, Hashimoto T, Zenda S, Harada H, Hirakawa K, Mizumoto M, Furutani K, Hironaka S, Fuji H, Murayama S: Analysis of dose-volume histogram parameters for radiation pneumonitis after definitive concurrent chemoradiotherapy for esophageal cancer. Radiother oncology: J European Society Therapeutic Radiology Oncology 2010, 95: 240-244. 10.1016/j.radonc.2010.02.006CrossRef

16.

Lin SH, Komaki R, Liao Z, Wei C, Myles B, Guo X, Palmer M, Mohan R, Swisher SG, Hofstetter WL: Proton beam therapy and concurrent chemotherapy for esophageal cancer. Int J Radiat Oncol Biol Phys 2012, 83: e345-351.CrossRefPubMedPubMedCentral

17.

Iijima M, Sakahara H: Radiation pneumonitis resembling bronchiolitis obliterans organizing pneumonia after postoperative irradiation for lung cancer: a case report. Nihon Igaku Hoshasen Gakkai zasshi Nippon acta radiologica 2003, 63: 332-333.PubMed

18.

Hamanishi T, Morimatu T, Oida K, Kori Y, Taguchi Y, Tanaka E, Inoue T, Kato T, Maniwa K, Kobashi Y, Noma S: Occurrence of BOOP outside radiation field after radiation therapy for small cell lung cancer. Nihon Kokyuki Gakkai zasshi = j Japanese Respiratory Society 2001, 39: 683-688.

19.

Murai T, Shibamoto Y, Nishiyama T, Baba F, Miyakawa A, Ayakawa S, Ogino H, Otsuka S, Iwata H: Organizing pneumonia after stereotactic ablative radiotherapy of the lung. Radiat Oncol 2012, 7: 123. 10.1186/1748-717X-7-123CrossRefPubMedPubMedCentral

20.

Varga Z, Cserhati A, Kelemen G, Boda K, Thurzo L, Kahan Z: Role of systemic therapy in the development of lung sequelae after conformal radiotherapy in breast cancer patients. Int J Radiat Oncol Biol Phys 2011, 80: 1109-1116. 10.1016/j.ijrobp.2010.03.044CrossRefPubMed

21.

Lind PA, Wennberg B, Gagliardi G, Fornander T: Pulmonary complications following different radiotherapy techniques for breast cancer, and the association to irradiated lung volume and dose. Breast Cancer Res Treat 2001, 68: 199-210. 10.1023/A:1012292019599CrossRefPubMed

22.

Blom Goldman U, Wennberg B, Svane G, Bylund H, Lind P: Reduction of radiation pneumonitis by V20-constraints in breast cancer. Radiat Oncol 2010, 5: 99. 10.1186/1748-717X-5-99CrossRefPubMed

Title: Relationship between radiation pneumonitis and organizing pneumonia after radiotherapy for breast cancer
Authors: Yumi Oie
Yasunori Saito
Masanao Kato
Fumitaka Ito
Hidekazu Hattori
Hiroshi Toyama
Hidetoshi Kobayashi
Kazuhiro Katada
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2013
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-8-56

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Relationship between radiation pneumonitis and organizing pneumonia after radiotherapy for breast cancer

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2013

3D-image-guided high-dose-rate intracavitary brachytherapy for salvage treatment of locally persistent nasopharyngeal carcinoma

Second primary cancers after radiation for prostate cancer: a review of data from planning studies

Improve definition of titanium tandems in MR-guided high dose rate brachytherapy for cervical cancer using proton density weighted MRI

Application of an interstitial and biodegradable balloon system for prostate-rectum separation during prostate cancer radiotherapy: a prospective multi-center study

Intraoperative electron radiation therapy (IOERT) in patients with locally recurrent renal cell carcinoma

Intensity modulated radiotherapy (IMRT) combined with concurrent but not adjuvant chemotherapy in primary nasopharyngeal cancer – a retrospective single center analysis