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Radiation Oncology

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Open Access 01-12-2010 | Research

Use of kilovoltage X-ray volume imaging in patient dose calculation for head-and-neck and partial brain radiation therapy

Authors: Weigang Hu, Jinsong Ye, Jiazhou Wang, Xuejun Ma, Zhen Zhang

Published in: Radiation Oncology | Issue 1/2010

Abstract

Background

To evaluate the accuracy of using kilovoltage x-ray cone-beam computed tomography (kV-CBCT) imaging for in vivo dose calculations.

Methods

A Region-of-Interest (ROI) CT number mapping method was developed to generate the cone-beam CT number vs. relative electron density calibration curve for 3D dose calculations. The stability of the results was validated for three consecutive months. The method was evaluated on three brain tumors and three head-and-neck tumor cases. For each patient, kV-CBCT images were acquired on the first treatment day and two-week intervals on the Elekta XVI system. The delivered dose distributions were calculated by applying the patients' treatment plans to the kV-CBCT images. The resulting dose distributions and dose volume histograms (DVHs) of the tumor and critical structures were compared to the original treatment plan.

Results

The kV-CBCT electron density calibration was stable within 1.5% over a three-month period. The DVH and dose distribution comparison based on the planning CT and the initial kV-CBCT showed good agreements for majority of cases. The doses calculated from the planning CT and kV-CBCT were compared on planes perpendicular to the beam axes and passing through the isocenter. Using γ analysis with a criterion of 2 mm/2% and a threshold of 10%, more than 99.5% of the points on the iso-planes exhibited γ <1. For one patient, kV-CBCT images detected 5.8% dose variation in the right parotid due to tumor shrinkage and patient weight loss.

Conclusions

ROI mapping method is an effective method for the creation of kV-CBCT electron density calibration curves for head-and-neck and brain tumor patients. Dose variations as monitored using kV-CBCT imaging suggest that some patients can benefit from adaptive treatment plan re-optimization.

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Title: Use of kilovoltage X-ray volume imaging in patient dose calculation for head-and-neck and partial brain radiation therapy
Authors: Weigang Hu
Jinsong Ye
Jiazhou Wang
Xuejun Ma
Zhen Zhang
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2010
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-5-29

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Use of kilovoltage X-ray volume imaging in patient dose calculation for head-and-neck and partial brain radiation therapy

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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