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Open Access 01-12-2014 | Letter to the Editor

Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab

Authors: Michiyuki Hakozaki, Takahiro Tajino, Hitoshi Yamada, Osamu Hasegawa, Kazuhiro Tasaki, Kazuo Watanabe, Shinichi Konno

Published in: Diagnostic Pathology | Issue 1/2014

Abstract

We describe a case of giant cell tumor of the proximal tibia with skip bone metastases of the ipsilateral femur in a 20-year-old man. After the neoadjuvant treatment with denosumab, plain radiographs and computed tomography showed marked osteosclerosis and sclerotic rim formation, and ¹⁸F-FDG PET/CT showed a decreased standardized uptake value, whereas magnetic resonance imaging showed diffuse enhancement of the tumor, nearly the same findings as those at pretreatment. Pathological findings of the surgical specimen after the denosumab treatment showed benign fibrous histiocytoma-like features with complete disappearance of both mononuclear stromal cells and multinuclear osteoclast-like giant cells.

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Title: Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab
Authors: Michiyuki Hakozaki
Takahiro Tajino
Hitoshi Yamada
Osamu Hasegawa
Kazuhiro Tasaki
Kazuo Watanabe
Shinichi Konno
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2014
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/1746-1596-9-111

2024 ASCO Annual Meeting

Springer Medicine

Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab

Abstract

Virtual Slides

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Virtual Slides

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