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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2010

Open Access 01-12-2010 | Case Report

A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases

Authors: Ira J Miller, Alan Blank, Suellen M Yin, Allison Mcnickle, Robert Gray, Steven Gitelis

Published in: Diagnostic Pathology | Issue 1/2010

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Abstract

Giant cell tumor (GCT) of bone is a locally destructive tumor that occurs predominantly in long bones of post-pubertal adolescents and young adults, where it occurs in the epiphysis. The majority are treated by aggressive curettage or resection. Vascular invasion outside the boundary of the tumor can be seen. Metastasis, with identical morphology to the primary tumor, occurs in a few percent of cases, usually to the lung. On occasion GCTs of bone undergo frank malignant transformation to undifferentiated sarcomas. Here we report a case of GCT of bone that at the time of recurrence was found to have undergone malignant transformation. Concurrent metastases were found in the lung, but these were non-transformed GCT.
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Metadata
Title
A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases
Authors
Ira J Miller
Alan Blank
Suellen M Yin
Allison Mcnickle
Robert Gray
Steven Gitelis
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2010
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-5-62

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