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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2012

Open Access 01-12-2012 | Research

Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis

Authors: Xue Qin, Qiliu Peng, Aiping Qin, Zhiping Chen, Liwen Lin, Yan Deng, Li Xie, Juanjuan Xu, Haiwei Li, Taijie Li, Shan Li, Jinmin Zhao

Published in: Diagnostic Pathology | Issue 1/2012

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Abstract

Background

Catechol-O-methyltransferase (COMT) is one of the most important enzymes involved in estrogen metabolism and its functional genetic polymorphisms may be associated with breast cancer (BC) risk. Many epidemiological studies have been conducted to explore the association between the COMT Val158Met polymorphism and breast cancer risk. However, the results remain inconclusive. In order to derive a more precise estimation of this relationship, a large meta-analysis was performed in this study.

Methods

Systematic searches of the PubMed, Embase and Cochrane Library were performed. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association.

Results

A total of 56 studies including 34,358 breast cancer cases and 45,429 controls were included. Overall, no significant associations between the COMT Val158Met polymorphism and breast cancer risk were found for LL versus HH, HL versus HH, LL versus HL, recessive model LL versus HL+HH, and dominant model LL+HL versus HH. In subgroup analysis by ethnicity, source of controls, and menopausal status, there was still no significant association detected in any of the genetic models.

Conclusion

Our meta-analysis results suggest that the COMT Val158Met polymorphism may not contribute to breast cancer susceptibility.

Virtual slides

The virtual slides(s) for this article can be found here:http://​www.​diagnosticpathol​ogy.​diagnomx.​eu/​vs48061235777084​17
Appendix
Available only for authorised users
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Metadata
Title
Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis
Authors
Xue Qin
Qiliu Peng
Aiping Qin
Zhiping Chen
Liwen Lin
Yan Deng
Li Xie
Juanjuan Xu
Haiwei Li
Taijie Li
Shan Li
Jinmin Zhao
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2012
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-7-136

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