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Cough
Published in: Cough 1/2013

Open Access 01-12-2013 | Review

The oesophagus and cough: laryngo-pharyngeal reflux, microaspiration and vagal reflexes

Authors: Jaclyn A Smith, Lesley A Houghton

Published in: Cough | Issue 1/2013

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Abstract

Gastro-oesophageal reflux disease is generally considered to be one of the commonest causes of chronic cough, however randomised controlled trials of proton pump inhibitors have often failed to support this notion. This article reviews the most recent studies investigating the mechanisms thought to link reflux and cough, namely laryngo-pharyngeal reflux, micro-aspiration and neuronal cross-organ sensitisation. How recent evidence might shed light on the failure of acid suppressing therapies and suggest new approaches to treating reflux related cough are also discussed.
Appendix
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Metadata
Title
The oesophagus and cough: laryngo-pharyngeal reflux, microaspiration and vagal reflexes
Authors
Jaclyn A Smith
Lesley A Houghton
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Cough / Issue 1/2013
Electronic ISSN: 1745-9974
DOI
https://doi.org/10.1186/1745-9974-9-12

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