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Molecular Pain
Published in: Molecular Pain 1/2013

Open Access 01-12-2013 | Review

Roles of phosphotase 2A in nociceptive signal processing

Authors: Yun Wang, Yongzhong Lei, Li Fang, Yonggao Mu, Jing Wu, Xuan Zhang

Published in: Molecular Pain | Issue 1/2013

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Abstract

Multiple protein kinases affect the responses of dorsal horn neurons through phosphorylation of synaptic receptors and proteins involved in intracellular signal transduction pathways, and the consequences of this modulation may be spinal central sensitization. In contrast, the phosphatases catalyze an opposing reaction of de-phosphorylation, which may also modulate the functions of crucial proteins in signaling nociception. This is an important mechanism in the regulation of intracellular signal transduction pathways in nociceptive neurons. Accumulated evidence has shown that phosphatase 2A (PP2A), a serine/threonine specific phosphatase, is implicated in synaptic plasticity of the central nervous system and central sensitization of nociception. Therefore, targeting protein phosphotase 2A may provide an effective and novel strategy for the treatment of clinical pain. This review will characterize the structure and functional regulation of neuronal PP2A and bring together recent advances on the modulation of PP2A in targeted downstream substrates and relevant multiple nociceptive signaling molecules.
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Metadata
Title
Roles of phosphotase 2A in nociceptive signal processing
Authors
Yun Wang
Yongzhong Lei
Li Fang
Yonggao Mu
Jing Wu
Xuan Zhang
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Molecular Pain / Issue 1/2013
Electronic ISSN: 1744-8069
DOI
https://doi.org/10.1186/1744-8069-9-46

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