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Molecular Pain
Published in: Molecular Pain 1/2008

Open Access 01-12-2008 | Short report

Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia

Authors: Michiko Nishiyori, Hiroshi Ueda

Published in: Molecular Pain | Issue 1/2008

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Abstract

In a new mouse model for generalized pain syndrome, including fibromyalgia, which used intermittent cold stress (ICS), bilateral allodynia in the hindpaw was observed that lasted more than 12 days; thermal hyperalgesia lasted 15 days. During constant cold stress (CCS), mice showed only a transient allodynia. A female prevalence in ICS-induced allodynia was observed in gonadectomized but not in gonad intact mice. Systemic gabapentin showed complete anti-allodynic effects in the ICS model at the one-tenth dose for injury-induced neuropathic pain model, and central gabapentin showed long-lasting analgesia for 4 days in ICS, but not the injury model. These results suggest that the ICS model is useful for the study of generalized pain syndrome.
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Metadata
Title
Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia
Authors
Michiko Nishiyori
Hiroshi Ueda
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Molecular Pain / Issue 1/2008
Electronic ISSN: 1744-8069
DOI
https://doi.org/10.1186/1744-8069-4-52

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