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Virology Journal
Published in: Virology Journal 1/2008

Open Access 01-12-2008 | Research

Concurrent infections by all four dengue virus serotypes during an outbreak of dengue in 2006 in Delhi, India

Authors: Preeti Bharaj, Harendra S Chahar, Anubhav Pandey, Kavita Diddi, Lalit Dar, Randeep Guleria, Sushil K Kabra, Shobha Broor

Published in: Virology Journal | Issue 1/2008

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Abstract

Background

Co-circulation of multiple dengue virus serotypes has been reported from many parts of the world including India, however concurrent infection with more than one serotype of dengue viruses in the same individual is rarely documented. An outbreak of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) occurred in and around Delhi in 2006. This is the first report from India with high percentage of concurrent infections with different dengue virus serotypes circulating during one outbreak.

Results

Acute phase sera from patients were tested for the presence of dengue virus RNA by RT-PCR assay. Of the 69 samples tested for dengue virus RNA, 48 (69.5%) were found to be positive. All the four dengue virus serotypes were found to be co-circulating in this outbreak with DENV-3 being the predominant serotype. In addition in 9 of 48 (19%) dengue virus positive samples, concurrent infection with more than one dengue virus serotype were identified.

Conclusion

This is the first report in which concurrent infections with different dengue virus serotypes is being reported during an outbreak from India. Delhi is now truly hyperendemic for dengue.
Appendix
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Literature
1.
Gubler DJ: Epidemic dengue/dengue haemorrhagic fever: a global public health problem in the 21 st century. Dengue Bulletin 1997, 21: 1-15.
2.
3.
Gubler DJ: Dengue and dengue hemorrhagic fever: its history and resurgence as a global public health problem. In Dengue and dengue hemorrhagic fever. Edited by: Gubler DJ, Kuno G. London: CAB International; 1997:1-22.
4.
Gubler DJ: Epidemic dengue/dengue haemorrhagic fever as a public health, social and economic problem in the 21 st century. Trends in Microbiology 2002, 10: 100-103. 10.1016/S0966-842X(01)02288-0CrossRefPubMed
5.
Gubler DJ: The arboviruses: epidemiology and ecology. In Dengue. Volume II. Edited by: Monath TP. CRC Press, Boca Raton, FL; 1988:223-260.
6.
7.
Innis BL, Nisalak A, Nimmannitya S, Kusalerdchariya S, Chongswasdi V, Suntayakorn S, Puttisri P, Hoke CH: An enzyme linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis co-circulate. Am J Trop Med Hyg 1989, 40: 418-427.PubMed
8.
9.
Yamada K, Nawa M, Takasaki T, Yaba S, Kurane I: Laboratory diagnosis of dengue virus infection by reverse transcriptase-polymerase chain reaction (RT-PCR) and IgM capture enzyme-linked immunosorbent assay (ELISA). Jpn J Infect Dis 1999, 52: 150-155.PubMed
10.
Sabin AB: Research on dengue during World War II. Am J Trop Med Hyg 1952, 1: 30-50.PubMed
11.
Risbud AR, Mehandale SM, Joshi GD, Banerjee K: Recurrent outbreaks of dengue fever in rural areas of Maharashtra (an experience from Parbhani district). Indian J Virol 1991, 7: 20-27.
12.
Sarkar JK, Pavri KM, Chatterjee SN, Chakravarty SK, Aanderson CR: Virological and serological studies of cases of haemorrhagic fever in Calcutta. Indian J Med Res 1964, 52: 684-691.PubMed
13.
Balaya S, Paul SD, D'Lima LV, Pavri KM: Investigations on an outbreak of dengue in Delhi in 1967. Indian J Med Res 1969, 57: 767-774.PubMed
14.
15.
Diesh P, Pattanayak S, Singha P, Arora DD, Mathur PS, Ghosh TK, Mondal MM, Raghavan NGS: An outbreak of dengue fever in Delhi – 1970. J Commun Dis 1972, 4: 13-18.
16.
Rao CVRM, Bagchi SK, Pinto BD, et al.: The 1982 epidemic of dengue fever in Delhi. Indian J Med Res 1985, 82: 271-275.PubMed
17.
Kabra SK, Verma IC, Arora NK, Jain Y, Kalra V: Dengue haemorrhagic fever in children in Delhi. Bull World Health Organ 1992, 70: 105-108.PubMedCentralPubMed
18.
Broor S, Dar L, Sengupta S, Chakaraborty M, Wali JP, Biswas A, Kabra SK, Jain Y, Seth P: Recent dengue epidemic in Delhi, India. In Factors in the Emergence of Arbovirus diseases. Edited by: Jean-François Saluzzo, Betty Dodet. Elsevier Science; 1997:123-127.
19.
Dar L, Gupta E, Narang P, Broor S: Co-circulation of dengue serotypes, Delhi, India, 2003. Letter to the editor. Emerg Infect Dis 2003,12(2):352-353.CrossRef
20.
21.
Laille M, Deubel V, Sinte-Marie FF: Demonstration of concurrent dengue 1 and dengue 3 infection in six patients by the polymerase chain reaction. J Med Virol 1991, 34: 51-54. 10.1002/jmv.1890340109CrossRefPubMed
22.
Maneekarn N, Morita K, Tanaka M, Igarashi A, Usawattanakul W, Sirisanthana V, Innis BL, Sittisombut N, Nisalak A, Nimmanitya S: Applications of polymerase chain reaction for identification of dengue viruses isolated from patient sera. Microbiol Immunol 1993, 37: 41-47.CrossRefPubMed
23.
Kanesa-Thasan N, Chang GJ, Smoak BL, Magill A, Burrous MJ, Hoke CH Jr: Molecular and epidemiologic analysis of dengue virus isolates from Somalia. Emerg Infect Dis 1998,4(2):299-303.PubMedCentralCrossRefPubMed
24.
Fang M, Chen C, Chen H, Tian X, Jiang L, Rao Y, Guo H: Detection of flaviviruses by reverse transcriptase-polymerase chain reaction with the universal primer set. Microbiol Immunol 1997, 41: 209-213.CrossRef
25.
Loroño-Pino MA, Cropp CB, Farfán JA, Vorndam AV, Rodriguez-Angulo EM, Rosado-Paredes EP, Flores-Flores LF, Beaty BJ, Gubler DJ: Common occurrence of concurrent infections by multiple dengue virus serotypes. Am J Trop Med Hyg 1999,61(5):725-730.PubMed
26.
Wang WK, Chao DY, Lin SR, Chang SC: Concurrent infections by two dengue virus serotypes among dengue patients in Taiwan. J Microbiol Immunol Infect 2003, 36: 89-95.PubMed
27.
28.
29.
Lanciotti RS, Calisher C, Gubler DJ, Chang G, Vorndam V: Rapid detection and typing of Dengue Viruses from clinical samples by using Reverse Transcriptase-Polymerase Chain Reaction. J Clin Virol 1992, 30: 545-555.
30.
Gubler DJ, Kuno G, Sather GE, Waterman SH: A case of natural concurrent human infection with two dengue viruses. Am J Trop Med Hyg 1985, 34: 170-173.PubMed
31.
32.
Wu SJ, Hanson B, Paxton H, Nisalak A, Vaughn DW, Rossi C, Henchal EA, Porter KR, Watts DM, Hayes CG: Evaluation of a dipstick enzyme linked immunosorbent assay for detection of antibodies to dengue virus. Clin Diagn Lab Immunol 1997, 4: 452-457.PubMedCentralPubMed
33.
Dash PK, Saxena P, Abhyankar A, Bhargava R, Jana AM: Emergence of dengue virus type-3 in northern India. Southeast Asian J Trop Med Public Health 2005, 36: 25-32.
34.
Worobey M, Rambaut A, Holmes EC: Widespread intraserotype recombination in natural populations of dengue virus. Proc Natl Acad Sci USA 1999, 96: 7352-7357. 10.1073/pnas.96.13.7352PubMedCentralCrossRefPubMed
Metadata
Title
Concurrent infections by all four dengue virus serotypes during an outbreak of dengue in 2006 in Delhi, India
Authors
Preeti Bharaj
Harendra S Chahar
Anubhav Pandey
Kavita Diddi
Lalit Dar
Randeep Guleria
Sushil K Kabra
Shobha Broor
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2008
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/1743-422X-5-1

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