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Virology Journal
Published in: Virology Journal 1/2013

Open Access 01-12-2013 | Review

Roles and functions of HIV-1 Tat protein in the CNS: an overview

Authors: Asen Bagashev, Bassel E Sawaya

Published in: Virology Journal | Issue 1/2013

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Abstract

Nearly 50% of HIV-infected individuals suffer from some form of HIV-associated neurocognitive disorders (HAND). HIV-1 Tat (a key HIV t ransa ctivator of t ranscription) protein is one of the first HIV proteins to be expressed after infection occurs and is absolutely required for the initiation of the HIV genome transcription. In addition to its canonical functions, various studies have shown the deleterious role of HIV-1 Tat in the development and progression of HAND. Within the CNS, only specific cell types can support productive viral replication (astrocytes and microglia), however Tat protein can be released form infected cells to affects HIV non-permissive cells such as neurons. Therefore, in this review, we will summarize the functions of HIV-1 Tat proteins in neural cells and its ability to promote HAND.
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Metadata
Title
Roles and functions of HIV-1 Tat protein in the CNS: an overview
Authors
Asen Bagashev
Bassel E Sawaya
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2013
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/1743-422X-10-358

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