Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Virology Journal
Published in: Virology Journal 1/2013

Open Access 01-12-2013 | Hypothesis

Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and CMV UL130 originate from chemokines

Authors: Maja Malkowska, Katarzyna Kokoszynska, Magdalena Dymecka, Leszek Rychlewski, Lucjan S Wyrwicz

Published in: Virology Journal | Issue 1/2013

Login to get access

Abstract

Herpesviridae is a large family of DNA viruses divided into three subfamilies: Alpha-, Beta- and Gammaherpesvirinae. The process of herpesvirus transmission is mediated by a range of proteins, one of which is glycoprotein L (gL). Based on our analysis of the solved structures of HSV2 and EBV gH/gL complexes, we propose that Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and Betaherpesvirinae UL130 originate from chemokines. Herpes simplex virus type 2 gL and human cytomegalovirus homolog (UL130) adopt a novel C chemokine-like fold, while Epstein-Barr virus gL mimics a CC chemokine structure. Hence, it is possible that gL interface with specific chemokine receptors during the transmission of Herpesviridae. We conclude that the further understanding of the function of viral chemokine-like proteins in Herpesviridae infection may lead to development of novel prophylactic and therapeutic treatment.
Appendix
Available only for authorised users
Literature
1.
Whitley RJ: Herpesviruses. In Medical Microbiology. 4th edition. Edited by: Baron S. Galveston (TX); 1996.
2.
Spear PG: Herpes simplex virus: receptors and ligands for cell entry. Cell Microbiol 2004,6(5):401-410. 10.1111/j.1462-5822.2004.00389.xPubMedCrossRef
3.
Roop C, Hutchinson L, Johnson DC: A mutant herpes simplex virus type 1 unable to express glycoprotein L cannot enter cells, and its particles lack glycoprotein H. J Virol 1993,67(4):2285-2297.PubMedPubMedCentral
4.
Geraghty RJ, Krummenacher C, Cohen GH, Eisenberg RJ, Spear PG: Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Science 1998,280(5369):1618-1620. 10.1126/science.280.5369.1618PubMedCrossRef
5.
Maclean CA: HSV Entry and Spread. Meth Mol Med 1998, 10: 9-18.
6.
Fernandez EJ, Lolis E: Structure, function, and inhibition of chemokines. Annu Rev Pharmacol Toxicol 2002, 42: 469-499. 10.1146/annurev.pharmtox.42.091901.115838PubMedCrossRef
7.
MacDonald MR, Li XY, Virgin HW: Late expression of a beta chemokine homolog by murine cytomegalovirus. J Virol 1997,71(2):1671-1678.PubMedPubMedCentral
8.
Smith CA, Smith TD, Smolak PJ, Friend D, Hagen H, Gerhart M, Park L, Pickup DJ, Torrance D, Mohler K, et al.: Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors. Virology 1997,236(2):316-327. 10.1006/viro.1997.8730PubMedCrossRef
9.
Littman DR: Chemokine receptors: keys to AIDS pathogenesis? Cell 1998,93(5):677-680. 10.1016/S0092-8674(00)81429-4PubMedCrossRef
10.
Murphy PM: Viral exploitation and subversion of the immune system through chemokine mimicry. Nat Immunol 2001,2(2):116-122. 10.1038/84214PubMedCrossRef
11.
Boomker JM, de Leij LF, The TH, Harmsen MC: Viral chemokine-modulatory proteins: tools and targets. Cytokine Growth Factor Rev 2005,16(1):91-103. 10.1016/j.cytogfr.2004.12.002PubMedCrossRef
12.
Wyrwicz LS, Rychlewski L: Herpes glycoprotein gL is distantly related to chemokine receptor ligands. Antiviral Res 2007,75(1):83-86. 10.1016/j.antiviral.2006.11.015PubMedCrossRef
13.
Chowdary TK, Cairns TM, Atanasiu D, Cohen GH, Eisenberg RJ, Heldwein EE: Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL. Nat Struct Mol Biol 2010,17(7):882-888. 10.1038/nsmb.1837PubMedPubMedCentralCrossRef
14.
Matsuura H, Kirschner AN, Longnecker R, Jardetzky TS: Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex. Proc Natl Acad Sci USA 2010,107(52):22641-22646. 10.1073/pnas.1011806108PubMedPubMedCentralCrossRef
15.
Kaptein SJ, van Cleef KW, Gruijthuijsen YK, Beuken EV, van Buggenhout L, Beisser PS, Stassen FR, Bruggeman CA, Vink C: The r131 gene of rat cytomegalovirus encodes a proinflammatory CC chemokine homolog which is essential for the production of infectious virus in the salivary glands. Virus Genes 2004,29(1):43-61.PubMedCrossRef
16.
Vomaske J, Denton M, Kreklywich C, Andoh T, Osborn JM, Chen D, Messaoudi I, Orloff SL, Streblow DN: Cytomegalovirus CC Chemokine Promotes Immune Cell Migration. J Virol 2012,86(21):11833-11844. 10.1128/JVI.00452-12PubMedPubMedCentralCrossRef
17.
Patrone M, Secchi M, Fiorina L, Ierardi M, Milanesi G, Gallina A: Human cytomegalovirus UL130 protein promotes endothelial cell infection through a producer cell modification of the virion. J Virol 2005,79(13):8361-8373. 10.1128/JVI.79.13.8361-8373.2005PubMedPubMedCentralCrossRef
18.
Rajarathnam K, Sykes BD, Dewald B, Baggiolini M, Clark-Lewis I: Disulfide bridges in interleukin-8 probed using non-natural disulfide analogues: dissociation of roles in structure from function. Biochemistry 1999,38(24):7653-7658. 10.1021/bi990033vPubMedCrossRef
19.
Vink C, Beisser PS, Bruggeman CA: Molecular mimicry by cytomegaloviruses. Function of cytomegalovirus-encoded homologues of G protein-coupled receptors, MHC class I heavy chains and chemokines. Intervirology 1999,42(5–6):342-349.PubMedCrossRef
20.
Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997,25(17):3389-3402. 10.1093/nar/25.17.3389PubMedPubMedCentralCrossRef
21.
Thompson JD, Gibson TJ, Higgins DG: Multiple sequence alignment using ClustalW and ClustalX. Current protocols in bioinformatics/editoral board, Andreas D Baxevanis [et al.]. 2002. Chapter 2:Unit 2 3
22.
McGuffin LJ, Bryson K, Jones DT: The PSIPRED protein structure prediction server. Bioinformatics 2000,16(4):404-405. 10.1093/bioinformatics/16.4.404PubMedCrossRef
23.
24.
Sali A, Blundell TL: Comparative protein modeling by satisfaction of spatial restraints. J Mol Biol 1993,234(3):779-815. 10.1006/jmbi.1993.1626PubMedCrossRef
25.
26.
Saccoccio FM, Sauer AL, Cui X, Armstrong AE, el SE H, Johnson DC, Ryckman BJ, Klingelhutz AJ, Adler SP, McVoy MA: Peptides from cytomegalovirus UL130 and UL131 proteins induce high titer antibodies that block viral entry into mucosal epithelial cells. Vaccine 2011,29(15):2705-2711. 10.1016/j.vaccine.2011.01.079PubMedPubMedCentralCrossRef
27.
Saccoccio FM, Gallagher MK, Adler SP, McVoy MA: Neutralizing activity of saliva against cytomegalovirus. Clin Vaccine Immunol: CVI 2011,18(9):1536-1542. 10.1128/CVI.05128-11PubMedPubMedCentralCrossRef
Metadata
Title
Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and CMV UL130 originate from chemokines
Authors
Maja Malkowska
Katarzyna Kokoszynska
Magdalena Dymecka
Leszek Rychlewski
Lucjan S Wyrwicz
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2013
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/1743-422X-10-1

Other articles of this Issue 1/2013

Virology Journal 1/2013 Go to the issue

Research

A new reporter mouse cytomegalovirus reveals maintained immediate-early gene expression but poor virus replication in cycling liver sinusoidal endothelial cells

Research

Respiratory infection of mice with mammalian reoviruses causes systemic infection with age and strain dependent pneumonia and encephalitis

Research

Detection of infections with hepatitis B virus, hepatitis C virus, and human immunodeficiency virus by analyses of dried blood spots - performance characteristics of the ARCHITECT system and two commercial assays for nucleic acid amplification

Research

Development and use of three monoclonal antibodies for the detection of rice black-streaked dwarf virus in field plants and planthopper vectors

Research

No association between XMRV or related gammaretroviruses in Australian prostate cancer patients

Short report

Characterization of HIV-1 gag and nef in Cameroon: further evidence of extreme diversity at the origin of the HIV-1 group M epidemic
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits