Skip to main content
Top
Published in: AIDS Research and Therapy 1/2011

Open Access 01-12-2011 | Review

Contraception in HIV-positive female adolescents

Authors: Nadia T Kancheva Landolt, Sudrak Lakhonphon, Jintanat Ananworanich

Published in: AIDS Research and Therapy | Issue 1/2011

Login to get access

Abstract

Sexual behavior of HIV-positive youths, whether infected perinatally, through risky behavior or other ways, is not substantially different from that of HIV-uninfected peers. Because of highly active antiretroviral therapy, increasing number of children, infected perinatally, are surviving into adolescence and are becoming sexually active and need reproductive health services. The objective of this article is to review the methods of contraception appropriate for HIV-positive adolescents with a special focus on hormonal contraceptives. Delaying the start of sexual life and the use of two methods thereafter, one of which is the male condom and the other a highly effective contraceptive method such as hormonal contraception or an intrauterine device, is currently the most effective option for those who desire simultaneous protection from both pregnancy and sexually transmitted diseases. Health care providers should be aware of the possible pharmacokinetic interactions between hormonal contraception and antiretrovirals. There is an urgent need for more information regarding metabolic outcomes of hormonal contraceptives, especially the effect of injectable progestins on bone metabolism, in HIV-positive adolescent girls.
Literature
2.
go back to reference Ezeanolue EE, Wodi AP, Patel R, Dieudonne A, Oleske JM: Sexual behaviors and procreational intentions of adolescents and young adults with perinatally acquired human immunodeficiency virus infection: experience of an urban tertiary center. J Adolesc Health. 2006, 38 (6): 719-25. 10.1016/j.jadohealth.2005.06.015CrossRefPubMed Ezeanolue EE, Wodi AP, Patel R, Dieudonne A, Oleske JM: Sexual behaviors and procreational intentions of adolescents and young adults with perinatally acquired human immunodeficiency virus infection: experience of an urban tertiary center. J Adolesc Health. 2006, 38 (6): 719-25. 10.1016/j.jadohealth.2005.06.015CrossRefPubMed
4.
go back to reference Levin L, Henry-Reid L, Murphy DA, Peralta L, Sarr M, Ma Y, Rogers AS, Adolescent Medicine HIV/AIDS Research Network: Incident pregnancy rates in HIV infected and HIV uninfected at-risk adolescents. J Adolesc Health. 2001, 29 (3 Suppl): 101-8.CrossRefPubMed Levin L, Henry-Reid L, Murphy DA, Peralta L, Sarr M, Ma Y, Rogers AS, Adolescent Medicine HIV/AIDS Research Network: Incident pregnancy rates in HIV infected and HIV uninfected at-risk adolescents. J Adolesc Health. 2001, 29 (3 Suppl): 101-8.CrossRefPubMed
5.
go back to reference Koenig LJ, Pals SL, Chandwani S, Hodge K, Abramowitz S, Barnes W, D'Angelo L: Sexual transmission risk behavior of adolescents With HIV acquired perinatally or through risky behaviors. J Acquir Immune Defic Syndr. 2010, 55 (3): 380-90. 10.1097/QAI.0b013e3181f0ccb6CrossRefPubMed Koenig LJ, Pals SL, Chandwani S, Hodge K, Abramowitz S, Barnes W, D'Angelo L: Sexual transmission risk behavior of adolescents With HIV acquired perinatally or through risky behaviors. J Acquir Immune Defic Syndr. 2010, 55 (3): 380-90. 10.1097/QAI.0b013e3181f0ccb6CrossRefPubMed
6.
go back to reference Rongkavilit C, Naar-King S, Chuenyam T, Wang B, Wright K, Phanuphak P: Health Risk Behaviors among HIV-Infected Youth in Bangkok, Thailand. J Adolesc Health. 2007, 40 (4): 358.e1-358.e8. 10.1016/j.jadohealth.2006.11.004.CrossRef Rongkavilit C, Naar-King S, Chuenyam T, Wang B, Wright K, Phanuphak P: Health Risk Behaviors among HIV-Infected Youth in Bangkok, Thailand. J Adolesc Health. 2007, 40 (4): 358.e1-358.e8. 10.1016/j.jadohealth.2006.11.004.CrossRef
7.
go back to reference Cruz ML, Cardoso CA, João EC, Gomes IM, Abreu TF, Oliveira RH, Machado ES, Dias IS, Rubini NM, Succi RM: Pregnancy in HIV vertically infected adolescents and young women: a new generation of HIV-exposed infants. AIDS. 2010, 24 (17): 2727-2731. 10.1097/QAD.0b013e32833e50d4CrossRefPubMed Cruz ML, Cardoso CA, João EC, Gomes IM, Abreu TF, Oliveira RH, Machado ES, Dias IS, Rubini NM, Succi RM: Pregnancy in HIV vertically infected adolescents and young women: a new generation of HIV-exposed infants. AIDS. 2010, 24 (17): 2727-2731. 10.1097/QAD.0b013e32833e50d4CrossRefPubMed
9.
go back to reference Kancheva Landolt N, Phanuphak N, Chaithongwongwatthana S, Ananworanich J: Sexual life and contraception in people living with HIV. Asian Biomedicine. 2010, 4 (5): 691-701. Kancheva Landolt N, Phanuphak N, Chaithongwongwatthana S, Ananworanich J: Sexual life and contraception in people living with HIV. Asian Biomedicine. 2010, 4 (5): 691-701.
10.
11.
go back to reference Patterson TL, Mausbach B, Lozada R, Staines-Orozco H, Semple SJ: Efficacy of a brief behavioral intervention to promote condom use among female sex workers in Tijuana and Ciudad Juarez, Mexico. Am J Public Health. 2008, 98 (11): 2051-2057. 10.2105/AJPH.2007.130096PubMedCentralCrossRefPubMed Patterson TL, Mausbach B, Lozada R, Staines-Orozco H, Semple SJ: Efficacy of a brief behavioral intervention to promote condom use among female sex workers in Tijuana and Ciudad Juarez, Mexico. Am J Public Health. 2008, 98 (11): 2051-2057. 10.2105/AJPH.2007.130096PubMedCentralCrossRefPubMed
12.
go back to reference Hiltabiddle SJ: Adolescent condom use, the health belief model, and the prevention of sexually transmitted disease. J Obstet Gynecol Neonatal Nurs. 1996, 25 (1): 61-6. 10.1111/j.1552-6909.1996.tb02514.xCrossRefPubMed Hiltabiddle SJ: Adolescent condom use, the health belief model, and the prevention of sexually transmitted disease. J Obstet Gynecol Neonatal Nurs. 1996, 25 (1): 61-6. 10.1111/j.1552-6909.1996.tb02514.xCrossRefPubMed
13.
go back to reference Wilson TE, Koenig LJ, Walter E, Fernandez I, Ethier K: Perinatal Guidelines Evaluation Project. Dual contraceptive method use for pregnancy and disease prevention among HIV-infected and HIV-uninfected women: the importance of an event-level focus for promoting safer sexual behaviors. Sex Transm Dis. 2003, 30 (11): 809-12. 10.1097/01.OLQ.0000086617.41012.14CrossRefPubMed Wilson TE, Koenig LJ, Walter E, Fernandez I, Ethier K: Perinatal Guidelines Evaluation Project. Dual contraceptive method use for pregnancy and disease prevention among HIV-infected and HIV-uninfected women: the importance of an event-level focus for promoting safer sexual behaviors. Sex Transm Dis. 2003, 30 (11): 809-12. 10.1097/01.OLQ.0000086617.41012.14CrossRefPubMed
14.
go back to reference Ngubane N, Patel D, Newell ML, Coovadia HM, Rollins N, Coutsoudis A: Messages about dual contraception in areas of high HIV prevalence are not heeded. S Afr Med J. 2008, 98 (3): 209-12.PubMed Ngubane N, Patel D, Newell ML, Coovadia HM, Rollins N, Coutsoudis A: Messages about dual contraception in areas of high HIV prevalence are not heeded. S Afr Med J. 2008, 98 (3): 209-12.PubMed
15.
go back to reference Berer M: Dual protection: more needed than practised or understood. Reprod Health Matters. 2006, 14 (28): 162-70. 10.1016/S0968-8080(06)28262-4CrossRefPubMed Berer M: Dual protection: more needed than practised or understood. Reprod Health Matters. 2006, 14 (28): 162-70. 10.1016/S0968-8080(06)28262-4CrossRefPubMed
16.
go back to reference Pazol K, Kramer MR, Hogue CJ: Condoms for dual protection: patterns of use with highly effective contraceptive methods. Public Health Rep. 2010, 125 (2): 208-17.PubMedCentralPubMed Pazol K, Kramer MR, Hogue CJ: Condoms for dual protection: patterns of use with highly effective contraceptive methods. Public Health Rep. 2010, 125 (2): 208-17.PubMedCentralPubMed
17.
go back to reference Mallet J, Kalambi V: Coerced and forced sterilization of HIV-positive women in Namibia. HIV AIDS Policy Law Re. 2008, 13 (2-3): 77-8. Mallet J, Kalambi V: Coerced and forced sterilization of HIV-positive women in Namibia. HIV AIDS Policy Law Re. 2008, 13 (2-3): 77-8.
18.
go back to reference Curtis KM, Mohllajee AP, Peterson HB: Regret following female sterilization at a young age: a systematic review. Contraception. 2006, 73 (2): 205-210. 10.1016/j.contraception.2005.08.006CrossRefPubMed Curtis KM, Mohllajee AP, Peterson HB: Regret following female sterilization at a young age: a systematic review. Contraception. 2006, 73 (2): 205-210. 10.1016/j.contraception.2005.08.006CrossRefPubMed
19.
go back to reference Stringer EM, Kaseba C, Levy J, Sinkala M, Goldenberg RL, Chi BH, Matongo I, Vermund SH, Mwanahamuntu M, Stringer JS: A randomized trial of the intrauterine contraceptive device vs hormonal contraception in women who are infected with the human immunodeficiency virus. Am J Obstet Gynecol. 2007, 197 (2): 144.e1-8. 10.1016/j.ajog.2007.03.031.CrossRef Stringer EM, Kaseba C, Levy J, Sinkala M, Goldenberg RL, Chi BH, Matongo I, Vermund SH, Mwanahamuntu M, Stringer JS: A randomized trial of the intrauterine contraceptive device vs hormonal contraception in women who are infected with the human immunodeficiency virus. Am J Obstet Gynecol. 2007, 197 (2): 144.e1-8. 10.1016/j.ajog.2007.03.031.CrossRef
20.
go back to reference Doll H, Vessey M, Painter R: Return of fertility in nulliparous women after discontinuation of the intrauterine device: comparison with women discontinuing other methods of contraception. BJOG. 2001, 108 (3): 304-14.PubMed Doll H, Vessey M, Painter R: Return of fertility in nulliparous women after discontinuation of the intrauterine device: comparison with women discontinuing other methods of contraception. BJOG. 2001, 108 (3): 304-14.PubMed
21.
go back to reference Zhang J, Feldblum PJ, Chi IC, Farr MG: Risk factors for copper T IUD expulsion: an epidemiologic analysis. Contraception. 1992, 46 (5): 427-33. 10.1016/0010-7824(92)90146-KCrossRefPubMed Zhang J, Feldblum PJ, Chi IC, Farr MG: Risk factors for copper T IUD expulsion: an epidemiologic analysis. Contraception. 1992, 46 (5): 427-33. 10.1016/0010-7824(92)90146-KCrossRefPubMed
22.
go back to reference Patchen L, Berggren EK: Use of the Copper T380A Intrauterine Device by Adolescent Mothers: Continuation and Method Failure. J Pediatr Adolesc Gynecol. 2011, 24 (2): 71-3. 10.1016/j.jpag.2010.07.010PubMedCentralCrossRefPubMed Patchen L, Berggren EK: Use of the Copper T380A Intrauterine Device by Adolescent Mothers: Continuation and Method Failure. J Pediatr Adolesc Gynecol. 2011, 24 (2): 71-3. 10.1016/j.jpag.2010.07.010PubMedCentralCrossRefPubMed
23.
go back to reference Gold MA, Johnson LM: Intrauterine devices and adolescents. Curr Opin Obstet Gynecol. 2008, 20 (5): 464-9. 10.1097/GCO.0b013e32830a98f8CrossRefPubMed Gold MA, Johnson LM: Intrauterine devices and adolescents. Curr Opin Obstet Gynecol. 2008, 20 (5): 464-9. 10.1097/GCO.0b013e32830a98f8CrossRefPubMed
25.
go back to reference Curtis KM, Nanda K, Kapp N: Safety of hormonal and intrauterine methods of contraception for women with HIV/AIDS: a systematic review. AIDS. 2009, 23 (suppl 1): S55-S67. 10.1097/01.aids.0000363778.58203.b6CrossRefPubMed Curtis KM, Nanda K, Kapp N: Safety of hormonal and intrauterine methods of contraception for women with HIV/AIDS: a systematic review. AIDS. 2009, 23 (suppl 1): S55-S67. 10.1097/01.aids.0000363778.58203.b6CrossRefPubMed
27.
go back to reference El-Ibiary SY, Cocohoba JM: Effects of HIV antiretrovirals on the pharmacokinetics of hormonal contraceptives. Eur J Contracept Reprod Health Care. 2008, 13 (2): 123-132. 10.1080/13625180701829952CrossRefPubMed El-Ibiary SY, Cocohoba JM: Effects of HIV antiretrovirals on the pharmacokinetics of hormonal contraceptives. Eur J Contracept Reprod Health Care. 2008, 13 (2): 123-132. 10.1080/13625180701829952CrossRefPubMed
28.
go back to reference Womack J, Williams A: Hormonal contraception in HIV-Positive Women. AIDS Reader. 2008, 18 (7): 372-376. 381.PubMed Womack J, Williams A: Hormonal contraception in HIV-Positive Women. AIDS Reader. 2008, 18 (7): 372-376. 381.PubMed
29.
go back to reference Hel Z, Stringer E, Mestecky J: Sex steroid hormones, HC, and the immunobiology of human immunodeficiency virus-1 infection. Endocr Rev. 2010, 31 (1): 79-97. 10.1210/er.2009-0018PubMedCentralCrossRefPubMed Hel Z, Stringer E, Mestecky J: Sex steroid hormones, HC, and the immunobiology of human immunodeficiency virus-1 infection. Endocr Rev. 2010, 31 (1): 79-97. 10.1210/er.2009-0018PubMedCentralCrossRefPubMed
30.
go back to reference Mingjia L, Short R: How oestrogen or progesterone might change a woman's susceptibility to HIV-1 infection. Aust N Z J Obstet Gynaecol. 2002, 42 (5): 472-5. 10.1111/j.0004-8666.2002.00472.xCrossRefPubMed Mingjia L, Short R: How oestrogen or progesterone might change a woman's susceptibility to HIV-1 infection. Aust N Z J Obstet Gynaecol. 2002, 42 (5): 472-5. 10.1111/j.0004-8666.2002.00472.xCrossRefPubMed
31.
go back to reference Baeten JM, Lavreys L, Overbaugh J: The influence of hormonal contraceptive use on HIV-1 transmission and disease progression. Clin Infect Dis. 2007, 45 (3): 360-9. 10.1086/519432CrossRefPubMed Baeten JM, Lavreys L, Overbaugh J: The influence of hormonal contraceptive use on HIV-1 transmission and disease progression. Clin Infect Dis. 2007, 45 (3): 360-9. 10.1086/519432CrossRefPubMed
32.
go back to reference Stringer EM, Levy J, Sinkala M, Chi BH, Matongo I, Chintu N, Stringer JS: HIV disease progression by hormonal contraceptive method: secondary analysis of a randomized trial. AIDS. 2009, 23 (11): 1377-82. 10.1097/QAD.0b013e32832cbca8PubMedCentralCrossRefPubMed Stringer EM, Levy J, Sinkala M, Chi BH, Matongo I, Chintu N, Stringer JS: HIV disease progression by hormonal contraceptive method: secondary analysis of a randomized trial. AIDS. 2009, 23 (11): 1377-82. 10.1097/QAD.0b013e32832cbca8PubMedCentralCrossRefPubMed
33.
go back to reference Smith SM, Baskin GB, Marx PA: Estrogen protects against vaginal transmission of simian immunodeficiency virus. J Infect Dis. 2000, 182 (3): 708-15. 10.1086/315776CrossRefPubMed Smith SM, Baskin GB, Marx PA: Estrogen protects against vaginal transmission of simian immunodeficiency virus. J Infect Dis. 2000, 182 (3): 708-15. 10.1086/315776CrossRefPubMed
34.
go back to reference Smith SM, Mefford M, Sodora D, Klase Z, Singh M, Alexander N, Hess D, Marx PA: Topical estrogen protects against SIV vaginal transmission without evidence of systemic effect. AIDS. 2004, 18 (12): 1637-43. 10.1097/01.aids.0000131393.76221.ccCrossRefPubMed Smith SM, Mefford M, Sodora D, Klase Z, Singh M, Alexander N, Hess D, Marx PA: Topical estrogen protects against SIV vaginal transmission without evidence of systemic effect. AIDS. 2004, 18 (12): 1637-43. 10.1097/01.aids.0000131393.76221.ccCrossRefPubMed
35.
go back to reference Stringer EM, Giganti M, Carter RJ, El-Sadr W, Abrams EJ, Stringer JS, MTCT-Plus Initiative: Hormonal contraception and HIV disease progression: a multicountry cohort analysis of the MTCT-Plus Initiative. AIDS. 2009, 23 (Suppl 1): S69-77. 10.1097/01.aids.0000363779.65827.e0CrossRefPubMed Stringer EM, Giganti M, Carter RJ, El-Sadr W, Abrams EJ, Stringer JS, MTCT-Plus Initiative: Hormonal contraception and HIV disease progression: a multicountry cohort analysis of the MTCT-Plus Initiative. AIDS. 2009, 23 (Suppl 1): S69-77. 10.1097/01.aids.0000363779.65827.e0CrossRefPubMed
36.
go back to reference Polis CB, Wawer MJ, Kiwanuka N, Laeyendecker O, Kagaayi J, Lutalo T, Nalugoda F, Kigozi G, Serwadda D, Gray RH: Effect of hormonal contraceptive use on HIV progression in female HIV seroconverters in Rakai, Uganda. AIDS. 2010, 24 (12): 1937-1944. 10.1097/QAD.0b013e32833b3282PubMedCentralCrossRefPubMed Polis CB, Wawer MJ, Kiwanuka N, Laeyendecker O, Kagaayi J, Lutalo T, Nalugoda F, Kigozi G, Serwadda D, Gray RH: Effect of hormonal contraceptive use on HIV progression in female HIV seroconverters in Rakai, Uganda. AIDS. 2010, 24 (12): 1937-1944. 10.1097/QAD.0b013e32833b3282PubMedCentralCrossRefPubMed
37.
go back to reference Richardson BA, Otieno PA, Mbori-Ngacha D, Overbaugh J, Farquhar C, John-Stewart GC: Hormonal contraception and HIV-1 disease progression among postpartum Kenyan women. AIDS. 2007, 21 (6): 749-753. 10.1097/QAD.0b013e328032790fPubMedCentralCrossRefPubMed Richardson BA, Otieno PA, Mbori-Ngacha D, Overbaugh J, Farquhar C, John-Stewart GC: Hormonal contraception and HIV-1 disease progression among postpartum Kenyan women. AIDS. 2007, 21 (6): 749-753. 10.1097/QAD.0b013e328032790fPubMedCentralCrossRefPubMed
38.
go back to reference Chu JH, Gange SJ, Anastos K, Minkoff H, Cejtin H, Bacon M, Levine A, Greenblatt RM: Hormonal contraceptive use and the effectiveness of highly active antiretroviral therapy. Am J Epidemiol. 2005, 161 (9): 881-90. 10.1093/aje/kwi116CrossRefPubMed Chu JH, Gange SJ, Anastos K, Minkoff H, Cejtin H, Bacon M, Levine A, Greenblatt RM: Hormonal contraceptive use and the effectiveness of highly active antiretroviral therapy. Am J Epidemiol. 2005, 161 (9): 881-90. 10.1093/aje/kwi116CrossRefPubMed
39.
go back to reference Kennedy M: Hormonal regulation of hepatic drug-metabolizing enzyme activity during adolescence. Clin Pharmacol Ther. 2008, 84 (6): 662-73. 10.1038/clpt.2008.202PubMedCentralCrossRefPubMed Kennedy M: Hormonal regulation of hepatic drug-metabolizing enzyme activity during adolescence. Clin Pharmacol Ther. 2008, 84 (6): 662-73. 10.1038/clpt.2008.202PubMedCentralCrossRefPubMed
40.
go back to reference van den Heuvel MW, van Bragt AJ, Alnabawy AK, Kaptein MC: Comparison of ethinylestradiol pharmacokineticss in three hormonal contraceptive formulations: the vaginal ring, the transdermal patch and an oral contraceptive. Contraception. 2005, 72 (3): 168-74. 10.1016/j.contraception.2005.03.005CrossRefPubMed van den Heuvel MW, van Bragt AJ, Alnabawy AK, Kaptein MC: Comparison of ethinylestradiol pharmacokineticss in three hormonal contraceptive formulations: the vaginal ring, the transdermal patch and an oral contraceptive. Contraception. 2005, 72 (3): 168-74. 10.1016/j.contraception.2005.03.005CrossRefPubMed
41.
go back to reference Westhoff CL, Torgal AH, Mayeda ER, Pike MC, Frank Z, Stanczyk FZ: Pharmacokinetics of a combined oral contraceptive in obese and normal-weight women. Contraception. 2010, 81 (6): 474-480. 10.1016/j.contraception.2010.01.016PubMedCentralCrossRefPubMed Westhoff CL, Torgal AH, Mayeda ER, Pike MC, Frank Z, Stanczyk FZ: Pharmacokinetics of a combined oral contraceptive in obese and normal-weight women. Contraception. 2010, 81 (6): 474-480. 10.1016/j.contraception.2010.01.016PubMedCentralCrossRefPubMed
42.
go back to reference Kuhnz W, Staks T, Jütting G: Pharmacokinetics of levonorgestrel and ethinylestradiol in 14 women during three months of treatment with a tri-step combination oral contraceptive: serum protein binding of levonorgestrel and influence of treatment on free and total testosterone levels in the serum. Contraception. 1994, 50 (6): 563-79. 10.1016/0010-7824(94)90014-0CrossRefPubMed Kuhnz W, Staks T, Jütting G: Pharmacokinetics of levonorgestrel and ethinylestradiol in 14 women during three months of treatment with a tri-step combination oral contraceptive: serum protein binding of levonorgestrel and influence of treatment on free and total testosterone levels in the serum. Contraception. 1994, 50 (6): 563-79. 10.1016/0010-7824(94)90014-0CrossRefPubMed
43.
go back to reference Cohn SE, Park JG, Watts DH, Stek A, Hitti J, Clax PA, Yu S, Lertora JJ, ACTG A5093 Protocol Team: Depo-medroxyprogesterone in women on antiretroviral therapy: effective contraception and lack of clinically significant interactions. Clin Pharmacol Ther. 2007, 81 (2): 222-7. 10.1038/sj.clpt.6100040CrossRefPubMed Cohn SE, Park JG, Watts DH, Stek A, Hitti J, Clax PA, Yu S, Lertora JJ, ACTG A5093 Protocol Team: Depo-medroxyprogesterone in women on antiretroviral therapy: effective contraception and lack of clinically significant interactions. Clin Pharmacol Ther. 2007, 81 (2): 222-7. 10.1038/sj.clpt.6100040CrossRefPubMed
44.
go back to reference Watts DH, Jeong-Gun Park JG, Cohn SE, Yu S, Hitti J, Stek A, Pamela A, Clax PA, Muderspach L, Lertora JJ: Safety and tolerability of depot medroxyprogesterone acetate among HIV-infected women on antiretroviral therapy: ACTG A5093. Contraception. 2008, 77 (2): 84-90. 10.1016/j.contraception.2007.10.002PubMedCentralCrossRefPubMed Watts DH, Jeong-Gun Park JG, Cohn SE, Yu S, Hitti J, Stek A, Pamela A, Clax PA, Muderspach L, Lertora JJ: Safety and tolerability of depot medroxyprogesterone acetate among HIV-infected women on antiretroviral therapy: ACTG A5093. Contraception. 2008, 77 (2): 84-90. 10.1016/j.contraception.2007.10.002PubMedCentralCrossRefPubMed
45.
go back to reference Nanda K, Amaral E, Hays M, Viscola MA, Mehta N, Bahamondes L: Pharmacokinetic interactions between depot medroxyprogesterone acetate and combination antiretroviral therapy. Fertil Steril. 2008, 90 (4): 965-71. 10.1016/j.fertnstert.2007.07.1348CrossRefPubMed Nanda K, Amaral E, Hays M, Viscola MA, Mehta N, Bahamondes L: Pharmacokinetic interactions between depot medroxyprogesterone acetate and combination antiretroviral therapy. Fertil Steril. 2008, 90 (4): 965-71. 10.1016/j.fertnstert.2007.07.1348CrossRefPubMed
46.
go back to reference Mildvan D, Yarrish R, Marshak A, Hutman HW, McDonough M, Lamson M, Robinson P: Pharmacokinetic interaction between nevirapine and ethinyl estradiol/norethindrone when administered concurrently to HIV-Infected women. J Acquir Immune Defic Syndr. 2002, 29 (5): 471-7.CrossRefPubMed Mildvan D, Yarrish R, Marshak A, Hutman HW, McDonough M, Lamson M, Robinson P: Pharmacokinetic interaction between nevirapine and ethinyl estradiol/norethindrone when administered concurrently to HIV-Infected women. J Acquir Immune Defic Syndr. 2002, 29 (5): 471-7.CrossRefPubMed
47.
go back to reference Joshi AS, Fiske WD, Benedek IH, White SJ, Joseph JL, Kornhauser DM: Lack of a pharmacokinetic interaction between efavirenz (DMP 266) and ethinyl estradiol in healthy female volunteers. Conf Retrovir Oppor Infect. 1998, 5: abstract no. 348- Joshi AS, Fiske WD, Benedek IH, White SJ, Joseph JL, Kornhauser DM: Lack of a pharmacokinetic interaction between efavirenz (DMP 266) and ethinyl estradiol in healthy female volunteers. Conf Retrovir Oppor Infect. 1998, 5: abstract no. 348-
48.
go back to reference Sevinsky H, Eley T, He B, Persson A, Garner D, Yones C, Nettles R, Bertz R, Zhang J: Effect of efavirenz on the pharmacokinetics of ethinyl estradiol and norgestimate in healthy female subjects. 48th Annual ICAAC/IDSA 46th Annual Meeting, October 25-28. 2008, Washington, DC. Sevinsky H, Eley T, He B, Persson A, Garner D, Yones C, Nettles R, Bertz R, Zhang J: Effect of efavirenz on the pharmacokinetics of ethinyl estradiol and norgestimate in healthy female subjects. 48th Annual ICAAC/IDSA 46th Annual Meeting, October 25-28. 2008, Washington, DC.
49.
go back to reference Schöller-Gyürea M, Kakudab TN, Woodfalla B, Aharchia F, Peetersa M, Vandermeulena K, Hoetelmansa RM: Effect of steady-state etravirine on the pharmacokinetics and pharmacodynamics of ethinylestradiol and norethindrone. Contraception. 2009, 80 (1): 44-52. 10.1016/j.contraception.2009.01.009CrossRef Schöller-Gyürea M, Kakudab TN, Woodfalla B, Aharchia F, Peetersa M, Vandermeulena K, Hoetelmansa RM: Effect of steady-state etravirine on the pharmacokinetics and pharmacodynamics of ethinylestradiol and norethindrone. Contraception. 2009, 80 (1): 44-52. 10.1016/j.contraception.2009.01.009CrossRef
50.
go back to reference Kearney BP, Mathias A: Lack of effect of tenofovir disoproxil fumarate on pharmacokinetics of hormonal contraceptives. Pharmacotherapy. 2009, 29 (8): 924-9. 10.1592/phco.29.8.924CrossRefPubMed Kearney BP, Mathias A: Lack of effect of tenofovir disoproxil fumarate on pharmacokinetics of hormonal contraceptives. Pharmacotherapy. 2009, 29 (8): 924-9. 10.1592/phco.29.8.924CrossRefPubMed
51.
go back to reference Ouellet D, Hsu A, Qian J, Locke CS, Eason CJ, Cavanaugh JH, Leonard JM, Granneman GR: Effect of ritonavir on the pharmacokinetics of ethinyl oestradiol in healthy female volunteers. Br J Clin Pharmacol. 1998, 46 (2): 111-6.PubMedCentralCrossRefPubMed Ouellet D, Hsu A, Qian J, Locke CS, Eason CJ, Cavanaugh JH, Leonard JM, Granneman GR: Effect of ritonavir on the pharmacokinetics of ethinyl oestradiol in healthy female volunteers. Br J Clin Pharmacol. 1998, 46 (2): 111-6.PubMedCentralCrossRefPubMed
52.
go back to reference Sekar VJ, Lefebvre E, Guzman SS, Felicione E, De Pauw M, Vangeneugden T, Hoetelmans RM: Pharmacokinetic interaction between ethinyl estradiol, norethindrone and darunavir with low-dose ritonavir in healthy women. Antivir Ther. 2008, 13 (4): 563-9.PubMed Sekar VJ, Lefebvre E, Guzman SS, Felicione E, De Pauw M, Vangeneugden T, Hoetelmans RM: Pharmacokinetic interaction between ethinyl estradiol, norethindrone and darunavir with low-dose ritonavir in healthy women. Antivir Ther. 2008, 13 (4): 563-9.PubMed
53.
go back to reference Vogler MA, Patterson K, Kamemoto L, Park JG, Watts H, Aweeka F, Klingman KL, Cohn SE: Contraceptive efficacy of oral and transdermal hormones when co-administered with protease inhibitors in HIV-1-infected women: pharmacokinetic results of ACTG trial A5188. J Acquir Immune Defic Syndr. 2010, 55 (4): 473-82. 10.1097/QAI.0b013e3181eb5ff5PubMedCentralCrossRefPubMed Vogler MA, Patterson K, Kamemoto L, Park JG, Watts H, Aweeka F, Klingman KL, Cohn SE: Contraceptive efficacy of oral and transdermal hormones when co-administered with protease inhibitors in HIV-1-infected women: pharmacokinetic results of ACTG trial A5188. J Acquir Immune Defic Syndr. 2010, 55 (4): 473-82. 10.1097/QAI.0b013e3181eb5ff5PubMedCentralCrossRefPubMed
54.
go back to reference Fröhlich M, Burhenne J, Martin-Facklam M, Weiss J, von Wolff M, Strowitzki T, Walter-Sack I, Haefeli WE: Oral contraception does not alter single dose saquinavir pharmacokinetics in women. Br J Clin Pharmacol. 2004, 57 (3): 244-52. 10.1111/j.1365-2125.2003.01983.xPubMedCentralCrossRefPubMed Fröhlich M, Burhenne J, Martin-Facklam M, Weiss J, von Wolff M, Strowitzki T, Walter-Sack I, Haefeli WE: Oral contraception does not alter single dose saquinavir pharmacokinetics in women. Br J Clin Pharmacol. 2004, 57 (3): 244-52. 10.1111/j.1365-2125.2003.01983.xPubMedCentralCrossRefPubMed
55.
go back to reference Tackett D, Child M, Agarwala S, Geiger M, Geraldes M, Laura B, O'Mara E: Atazanavir: a summary of two pharmacokinetic drug interaction studies in healthy subjects. Conf Retrovir Oppor Infect. 2003, 10: abstract no. 543- Tackett D, Child M, Agarwala S, Geiger M, Geraldes M, Laura B, O'Mara E: Atazanavir: a summary of two pharmacokinetic drug interaction studies in healthy subjects. Conf Retrovir Oppor Infect. 2003, 10: abstract no. 543-
56.
go back to reference Abel S, Russell D, Whitlock LA, Ridgway CE, Muirhead GJ: Effect of maraviroc on the pharmacokinetics of midazolam, lamivudine/zidovudine, and ethinyloestradiol/levonorgestrel in healthy volunteers. Br J Clin Pharmacol. 2008, 65 (Suppl 1): 19-26.PubMedCentralCrossRefPubMed Abel S, Russell D, Whitlock LA, Ridgway CE, Muirhead GJ: Effect of maraviroc on the pharmacokinetics of midazolam, lamivudine/zidovudine, and ethinyloestradiol/levonorgestrel in healthy volunteers. Br J Clin Pharmacol. 2008, 65 (Suppl 1): 19-26.PubMedCentralCrossRefPubMed
60.
go back to reference Becker KL: Principles and practice of endocrinology and metabolism. 2001, 1018-Philadelphia: Lippincott Williams and Wilkins. Becker KL: Principles and practice of endocrinology and metabolism. 2001, 1018-Philadelphia: Lippincott Williams and Wilkins.
61.
go back to reference Schindler AE: Non-contraceptive benefits of hormonal contraceptives. Minerva Ginecol. 2010, 62 (4): 319-29.PubMed Schindler AE: Non-contraceptive benefits of hormonal contraceptives. Minerva Ginecol. 2010, 62 (4): 319-29.PubMed
62.
go back to reference Womack JA, Scherzer R, Cole SR, Fennie K, Williams AB, Grey M, Minkoff H, Anastos K, Cohen MH, Tien PC: Hormonal contraception and metabolic outcomes in women with or at risk for HIV infection. J Acquir Immune Defic Syndr. 2009, 52 (5): 581-7. 10.1097/QAI.0b013e3181b9e5eePubMedCentralCrossRefPubMed Womack JA, Scherzer R, Cole SR, Fennie K, Williams AB, Grey M, Minkoff H, Anastos K, Cohen MH, Tien PC: Hormonal contraception and metabolic outcomes in women with or at risk for HIV infection. J Acquir Immune Defic Syndr. 2009, 52 (5): 581-7. 10.1097/QAI.0b013e3181b9e5eePubMedCentralCrossRefPubMed
63.
go back to reference Beksinska ME, Kleinschmidt I, Smit JA, Farley TM, Rees HV: Bone mineral density in young women aged 19-24 after 4-5 years of exclusive and mixed use of hormonal contraception. Contraception. 2009, 80 (2): 128-32. 10.1016/j.contraception.2009.02.001CrossRefPubMed Beksinska ME, Kleinschmidt I, Smit JA, Farley TM, Rees HV: Bone mineral density in young women aged 19-24 after 4-5 years of exclusive and mixed use of hormonal contraception. Contraception. 2009, 80 (2): 128-32. 10.1016/j.contraception.2009.02.001CrossRefPubMed
65.
go back to reference Harel Z, Johnson CC, Gold MA, Cromer B, Peterson E, Burkman R, Stager M, Brown R, Bruner A, Coupey S, Hertweck P, Bone H, Wolter K, Nelson A, Marshall S, Bachrach LK: Recovery of bone mineral density in adolescents following the use of depot medroxyprogesterone acetate contraceptive injections. Contraception. 2010, 81 (4): 281-91. 10.1016/j.contraception.2009.11.003CrossRefPubMed Harel Z, Johnson CC, Gold MA, Cromer B, Peterson E, Burkman R, Stager M, Brown R, Bruner A, Coupey S, Hertweck P, Bone H, Wolter K, Nelson A, Marshall S, Bachrach LK: Recovery of bone mineral density in adolescents following the use of depot medroxyprogesterone acetate contraceptive injections. Contraception. 2010, 81 (4): 281-91. 10.1016/j.contraception.2009.11.003CrossRefPubMed
66.
go back to reference Pongsatha S, Ekmahachai M, Chaovisitsaree S, Suntornlimsiri N, Morakote N: Bone mineral density in women using depot medroxyprogesterone acetate (DMPA) for at least 2 years compared to a control group: a cross sectional study. J Med Assoc Thai. 2009, 92 (10): 1263-7.PubMed Pongsatha S, Ekmahachai M, Chaovisitsaree S, Suntornlimsiri N, Morakote N: Bone mineral density in women using depot medroxyprogesterone acetate (DMPA) for at least 2 years compared to a control group: a cross sectional study. J Med Assoc Thai. 2009, 92 (10): 1263-7.PubMed
67.
go back to reference McComsey GA, Tebas P, Shane E, Yin MT, Overton ET, Huang JS, Aldrovandi GM, Cardoso SW, Santana JL, Brown TT: Bone disease in HIV infection: a practical review and recommendations for HIV care providers. Clin Infect Dis. 2010, 51 (8): 937-46. 10.1086/656412PubMedCentralCrossRefPubMed McComsey GA, Tebas P, Shane E, Yin MT, Overton ET, Huang JS, Aldrovandi GM, Cardoso SW, Santana JL, Brown TT: Bone disease in HIV infection: a practical review and recommendations for HIV care providers. Clin Infect Dis. 2010, 51 (8): 937-46. 10.1086/656412PubMedCentralCrossRefPubMed
68.
go back to reference Beksinska ME, Smit JA, Ramkissoon A: Progestogen-only injectable hormonal contraceptive use should be considered in analysis of studies addressing the loss of bone mineral density in HIV-positive women. J Acquir Immune Defic Syndr. 2010, 54 (4): e5.-CrossRefPubMed Beksinska ME, Smit JA, Ramkissoon A: Progestogen-only injectable hormonal contraceptive use should be considered in analysis of studies addressing the loss of bone mineral density in HIV-positive women. J Acquir Immune Defic Syndr. 2010, 54 (4): e5.-CrossRefPubMed
69.
go back to reference Mora S, Sala N, Bricalli D, Zuin G, Chiumello G, Viganò A: Bone mineral loss through increased bone turnover in HIV-infected children treated with highly active antiretroviral therapy. AIDS. 2001, 15 (14): 1823-9. 10.1097/00002030-200109280-00011CrossRefPubMed Mora S, Sala N, Bricalli D, Zuin G, Chiumello G, Viganò A: Bone mineral loss through increased bone turnover in HIV-infected children treated with highly active antiretroviral therapy. AIDS. 2001, 15 (14): 1823-9. 10.1097/00002030-200109280-00011CrossRefPubMed
70.
go back to reference Hengcharoen S, Chaithongwongwatthana S: Awareness of Emergency Contraception in Adolescent Mothers. Thai J Obstet Gynecol. 2009, 17: 175-180. Hengcharoen S, Chaithongwongwatthana S: Awareness of Emergency Contraception in Adolescent Mothers. Thai J Obstet Gynecol. 2009, 17: 175-180.
71.
go back to reference Carten ML, Kiser J, Kwara A, MaWhinney S, Cu-Uvin S: Pharmacokinetic (PK) Interactions between the Hormonal Emergency Contraception Plan B®(Levonorgestrel) and Efavirenz (EFV). Conf Retrovir Oppor Infect. 2010, 17: abstract no. 934- Carten ML, Kiser J, Kwara A, MaWhinney S, Cu-Uvin S: Pharmacokinetic (PK) Interactions between the Hormonal Emergency Contraception Plan B®(Levonorgestrel) and Efavirenz (EFV). Conf Retrovir Oppor Infect. 2010, 17: abstract no. 934-
Metadata
Title
Contraception in HIV-positive female adolescents
Authors
Nadia T Kancheva Landolt
Sudrak Lakhonphon
Jintanat Ananworanich
Publication date
01-12-2011
Publisher
BioMed Central
Published in
AIDS Research and Therapy / Issue 1/2011
Electronic ISSN: 1742-6405
DOI
https://doi.org/10.1186/1742-6405-8-19

Other articles of this Issue 1/2011

AIDS Research and Therapy 1/2011 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.