Skip to main content
Top
Published in: Journal of the International Society of Sports Nutrition 1/2009

Open Access 01-12-2009 | Research article

The effects of four weeks of creatine supplementation and high-intensity interval training on cardiorespiratory fitness: a randomized controlled trial

Authors: Jennifer L Graef, Abbie E Smith, Kristina L Kendall, David H Fukuda, Jordan R Moon, Travis W Beck, Joel T Cramer, Jeffrey R Stout

Published in: Journal of the International Society of Sports Nutrition | Issue 1/2009

Login to get access

Abstract

Background

High-intensity interval training has been shown to be a time-efficient way to induce physiological adaptations similar to those of traditional endurance training. Creatine supplementation may enhance high-intensity interval training, leading to even greater physiological adaptations. The purpose of this study was to determine the effects of high-intensity interval training (HIIT) and creatine supplementation on cardiorespiratory fitness and endurance performance (maximal oxygen consumption (VO2PEAK), time-to-exhaustion (VO2PEAKTTE), ventilatory threshold (VT), and total work done (TWD)) in college-aged men.

Methods

Forty-three recreationally active men completed a graded exercise test to determine VO2PEAK, VO2PEAKTTE, and VT. In addition, participants completed a time to exhaustion (TTE) ride at 110% of the maximum workload reached during the graded exercise test to determine TWD (TTE (sec) × W = J). Following testing, participants were randomly assigned to one of three groups: creatine (creatine citrate) (Cr; n = 16), placebo (PL; n = 17), or control (n = 10) groups. The Cr and PL groups completed four weeks of HIIT prior to post-testing.

Results

Significant improvements in VO2PEAK and VO2PEAKTTE occurred in both training groups. Only the Cr group significantly improved VT (16% vs. 10% improvement in PL). No changes occurred in TWD in any group.

Conclusion

In conclusion, HIIT is an effective and time-efficient way to improve maximal endurance performance. The addition of Cr improved VT, but did not increase TWD. Therefore, 10 g of Cr per day for five days per week for four weeks does not seem to further augment maximal oxygen consumption, greater than HIIT alone; however, Cr supplementation may improve submaximal exercise performance.
Appendix
Available only for authorised users
Literature
1.
go back to reference Coyle EF: Integration of the physiological factors determining endurance performance ability. Exerc Sport Sci Rev. 1995, 23 (25-63): Coyle EF: Integration of the physiological factors determining endurance performance ability. Exerc Sport Sci Rev. 1995, 23 (25-63):
2.
go back to reference Hawley JA: Adaptations of skeletal muscle to prolonged, intense endurance training. Clin Exp Pharmacol Physiol. 2002, 29 (3): 218-22. 10.1046/j.1440-1681.2002.03623.x.CrossRefPubMed Hawley JA: Adaptations of skeletal muscle to prolonged, intense endurance training. Clin Exp Pharmacol Physiol. 2002, 29 (3): 218-22. 10.1046/j.1440-1681.2002.03623.x.CrossRefPubMed
3.
go back to reference Holloszy JO, Coyle EF: Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol. 1984, 56 (4): 831-8.PubMed Holloszy JO, Coyle EF: Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol. 1984, 56 (4): 831-8.PubMed
4.
go back to reference Burgomaster KA, Hughes SC, Heigenhauser GJ, Bradwell SN, Gibala MJ: Six sessions of sprint interval training increases muscle oxidative potential and cycle endurance capacity in humans. J Appl Physiol. 2005, 98 (6): 1985-90. 10.1152/japplphysiol.01095.2004.CrossRefPubMed Burgomaster KA, Hughes SC, Heigenhauser GJ, Bradwell SN, Gibala MJ: Six sessions of sprint interval training increases muscle oxidative potential and cycle endurance capacity in humans. J Appl Physiol. 2005, 98 (6): 1985-90. 10.1152/japplphysiol.01095.2004.CrossRefPubMed
5.
go back to reference Harmer AR, McKenna MJ, Sutton JR, Snow RJ, Ruell PA, Booth J, Thompson MW, Mackay NA, Stathis CG, Crameri RM, Carey MF, Eager DM: Skeletal muscle metabolic and ionic adaptations during intense exercise following sprint training in humans. J Appl Physiol. 2000, 89 (5): 1793-803.PubMed Harmer AR, McKenna MJ, Sutton JR, Snow RJ, Ruell PA, Booth J, Thompson MW, Mackay NA, Stathis CG, Crameri RM, Carey MF, Eager DM: Skeletal muscle metabolic and ionic adaptations during intense exercise following sprint training in humans. J Appl Physiol. 2000, 89 (5): 1793-803.PubMed
6.
go back to reference Burgomaster KA, Heigenhauser GJ, Gibala MJ: Effect of short-term sprint interval training on human skeletal muscle carbohydrate metabolism during exercise and time-trial performance. J Appl Physiol. 2006, 100 (6): 2041-7. 10.1152/japplphysiol.01220.2005.CrossRefPubMed Burgomaster KA, Heigenhauser GJ, Gibala MJ: Effect of short-term sprint interval training on human skeletal muscle carbohydrate metabolism during exercise and time-trial performance. J Appl Physiol. 2006, 100 (6): 2041-7. 10.1152/japplphysiol.01220.2005.CrossRefPubMed
7.
go back to reference Weston AR, Myburgh KH, Lindsay FH, Dennis SC, Noakes TD, Hawley JA: Skeletal muscle buffering capacity and endurance performance after high-intensity interval training by well-trained cyclists. Eur J Appl Physiol Occup Physiol. 1997, 75 (1): 7-13. 10.1007/s004210050119.CrossRefPubMed Weston AR, Myburgh KH, Lindsay FH, Dennis SC, Noakes TD, Hawley JA: Skeletal muscle buffering capacity and endurance performance after high-intensity interval training by well-trained cyclists. Eur J Appl Physiol Occup Physiol. 1997, 75 (1): 7-13. 10.1007/s004210050119.CrossRefPubMed
8.
go back to reference Edge J, Bishop D, Goodman C: The effects of training intensity on muscle buffer capacity in females. Eur J Appl Physiol. 2006, 96 (1): 97-105. 10.1007/s00421-005-0068-6.CrossRefPubMed Edge J, Bishop D, Goodman C: The effects of training intensity on muscle buffer capacity in females. Eur J Appl Physiol. 2006, 96 (1): 97-105. 10.1007/s00421-005-0068-6.CrossRefPubMed
9.
go back to reference Laursen PB, Shing CM, Peake JM, Coombes JS, Jenkins DG: Influence of high-intensity interval training on adaptations in well-trained cyclists. J Strength Cond Res. 2005, 19 (3): 527-33. 10.1519/15964.1.PubMed Laursen PB, Shing CM, Peake JM, Coombes JS, Jenkins DG: Influence of high-intensity interval training on adaptations in well-trained cyclists. J Strength Cond Res. 2005, 19 (3): 527-33. 10.1519/15964.1.PubMed
10.
go back to reference Jenkins DG, Quigley BM: The influence of high-intensity exercise training on the Wlim-Tlim relationship. Med Sci Sports Exerc. 1993, 25 (2): 275-82.PubMed Jenkins DG, Quigley BM: The influence of high-intensity exercise training on the Wlim-Tlim relationship. Med Sci Sports Exerc. 1993, 25 (2): 275-82.PubMed
11.
go back to reference Helgerud J, Hoydal K, Wang E, Karlsen T, Berg P, Bjerkaas M, Simonsen T, Helgesen C, Hjorth N, Bach R, Hoff J: Aerobic high-intensity intervals improve VO2max more than moderate training. Med Sci Sports Exerc. 2007, 39 (4): 665-71. 10.1249/mss.0b013e3180304570.CrossRefPubMed Helgerud J, Hoydal K, Wang E, Karlsen T, Berg P, Bjerkaas M, Simonsen T, Helgesen C, Hjorth N, Bach R, Hoff J: Aerobic high-intensity intervals improve VO2max more than moderate training. Med Sci Sports Exerc. 2007, 39 (4): 665-71. 10.1249/mss.0b013e3180304570.CrossRefPubMed
12.
go back to reference Burke J, Thayer R, Belcamino M: Comparison of effects of two interval-training programmes on lactate and ventilatory thresholds. Br J Sports Med. 1994, 28 (1): 18-21. 10.1136/bjsm.28.1.18.PubMedCentralCrossRefPubMed Burke J, Thayer R, Belcamino M: Comparison of effects of two interval-training programmes on lactate and ventilatory thresholds. Br J Sports Med. 1994, 28 (1): 18-21. 10.1136/bjsm.28.1.18.PubMedCentralCrossRefPubMed
13.
go back to reference Cottrell GT, Coast JR, Herb RA: Effect of recovery interval on multiple-bout sprint cycling performance after acute creatine supplementation. J Strength Cond Res. 2002, 16 (1): 109-16. 10.1519/1533-4287(2002)016<0109:EORIOM>2.0.CO;2.PubMed Cottrell GT, Coast JR, Herb RA: Effect of recovery interval on multiple-bout sprint cycling performance after acute creatine supplementation. J Strength Cond Res. 2002, 16 (1): 109-16. 10.1519/1533-4287(2002)016<0109:EORIOM>2.0.CO;2.PubMed
14.
go back to reference Bogdanis GC, Nevill ME, Boobis LH, Lakomy HK, Nevill AM: Recovery of power output and muscle metabolites following 30 s of maximal sprint cycling in man. J Physiol. 1995, 482 (Pt 2): 467-80.PubMedCentralCrossRefPubMed Bogdanis GC, Nevill ME, Boobis LH, Lakomy HK, Nevill AM: Recovery of power output and muscle metabolites following 30 s of maximal sprint cycling in man. J Physiol. 1995, 482 (Pt 2): 467-80.PubMedCentralCrossRefPubMed
15.
go back to reference Hultman E, Soderlund K, Timmons JA, Cederblad G, Greenhaff PL: Muscle creatine loading in men. J Appl Physiol. 1996, 81 (1): 232-7.PubMed Hultman E, Soderlund K, Timmons JA, Cederblad G, Greenhaff PL: Muscle creatine loading in men. J Appl Physiol. 1996, 81 (1): 232-7.PubMed
16.
go back to reference Harris RC, Soderlund K, Hultman E: Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci (Lond). 1992, 83 (3): 367-74.CrossRef Harris RC, Soderlund K, Hultman E: Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci (Lond). 1992, 83 (3): 367-74.CrossRef
17.
go back to reference Stout J, Eckerson J, Ebersole K, Moore G, Perry S, Housh T, Bull A, Cramer J, Batheja A: Effect of creatine loading on neuromuscular fatigue threshold. J Appl Physiol. 2000, 88 (1): 109-12.PubMed Stout J, Eckerson J, Ebersole K, Moore G, Perry S, Housh T, Bull A, Cramer J, Batheja A: Effect of creatine loading on neuromuscular fatigue threshold. J Appl Physiol. 2000, 88 (1): 109-12.PubMed
18.
go back to reference Volek JS, Kraemer WJ: Creatine Supplementation: Its effect on human muscular performance and body composition. J Strength Cond Res. 1996, 10 (200-210): Volek JS, Kraemer WJ: Creatine Supplementation: Its effect on human muscular performance and body composition. J Strength Cond Res. 1996, 10 (200-210):
19.
go back to reference Derave W, Eijnde BO, Verbessem P, Ramaekers M, Van Leemputte M, Richter EA, Hespel P: Combined creatine and protein supplementation in conjunction with resistance training promotes muscle GLUT-4 content and glucose tolerance in humans. J Appl Physiol. 2003, 94 (5): 1910-6.CrossRefPubMed Derave W, Eijnde BO, Verbessem P, Ramaekers M, Van Leemputte M, Richter EA, Hespel P: Combined creatine and protein supplementation in conjunction with resistance training promotes muscle GLUT-4 content and glucose tolerance in humans. J Appl Physiol. 2003, 94 (5): 1910-6.CrossRefPubMed
20.
go back to reference Orr GW, Green HJ, Hughson RL, Bennett GW: A computer linear regression model to determine ventilatory anaerobic threshold. J Appl Physiol. 1982, 52 (5): 1349-52.PubMed Orr GW, Green HJ, Hughson RL, Bennett GW: A computer linear regression model to determine ventilatory anaerobic threshold. J Appl Physiol. 1982, 52 (5): 1349-52.PubMed
21.
go back to reference Talanian JL, Galloway SD, Heigenhauser GJ, Bonen A, Spriet LL: Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women. J Appl Physiol. 2007, 102 (4): 1439-47. 10.1152/japplphysiol.01098.2006.CrossRefPubMed Talanian JL, Galloway SD, Heigenhauser GJ, Bonen A, Spriet LL: Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women. J Appl Physiol. 2007, 102 (4): 1439-47. 10.1152/japplphysiol.01098.2006.CrossRefPubMed
22.
go back to reference Smith AE, Moon JR, Kendall KL, Graef JL, Lockwood CM, Walter AA, Beck TW, Cramer JT, Stout JR: The effects of beta-alanine supplementation and high-intensity interval training on neuromuscular fatigue and muscle function. Eur J Appl Physiol. 2009, 105 (3): 357-63. 10.1007/s00421-008-0911-7.CrossRefPubMed Smith AE, Moon JR, Kendall KL, Graef JL, Lockwood CM, Walter AA, Beck TW, Cramer JT, Stout JR: The effects of beta-alanine supplementation and high-intensity interval training on neuromuscular fatigue and muscle function. Eur J Appl Physiol. 2009, 105 (3): 357-63. 10.1007/s00421-008-0911-7.CrossRefPubMed
23.
go back to reference Daniels JT, Yarbrough RA, Foster C: Changes in VO2 max and running performance with training. Eur J Appl Physiol Occup Physiol. 1978, 39 (4): 249-54. 10.1007/BF00421448.CrossRefPubMed Daniels JT, Yarbrough RA, Foster C: Changes in VO2 max and running performance with training. Eur J Appl Physiol Occup Physiol. 1978, 39 (4): 249-54. 10.1007/BF00421448.CrossRefPubMed
24.
go back to reference Dolgener FA, Brooks WB: The effects of interval and continuous training on VO2 max and performance in the mile run. J Sports Med Phys Fitness. 1978, 18 (4): 345-52.PubMed Dolgener FA, Brooks WB: The effects of interval and continuous training on VO2 max and performance in the mile run. J Sports Med Phys Fitness. 1978, 18 (4): 345-52.PubMed
25.
go back to reference Thomas TR, Adeniran SB, Etheridge GL: Effects of different running programs on VO2 max, percent fat, and plasma lipids. Can J Appl Sport Sci. 1984, 9 (2): 55-62.PubMed Thomas TR, Adeniran SB, Etheridge GL: Effects of different running programs on VO2 max, percent fat, and plasma lipids. Can J Appl Sport Sci. 1984, 9 (2): 55-62.PubMed
26.
go back to reference Westgarth-Taylor C, Hawley JA, Rickard S, Myburgh KH, Noakes TD, Dennis SC: Metabolic and performance adaptations to interval training in endurance-trained cyclists. Eur J Appl Physiol Occup Physiol. 1997, 75 (4): 298-304. 10.1007/s004210050164.CrossRefPubMed Westgarth-Taylor C, Hawley JA, Rickard S, Myburgh KH, Noakes TD, Dennis SC: Metabolic and performance adaptations to interval training in endurance-trained cyclists. Eur J Appl Physiol Occup Physiol. 1997, 75 (4): 298-304. 10.1007/s004210050164.CrossRefPubMed
27.
go back to reference Burgomaster KA, Howarth KR, Phillips SM, Rakobowchuk M, Macdonald MJ, McGee SL, Gibala MJ: Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. J Physiol. 2008, 586 (1): 151-60. 10.1113/jphysiol.2007.142109.PubMedCentralCrossRefPubMed Burgomaster KA, Howarth KR, Phillips SM, Rakobowchuk M, Macdonald MJ, McGee SL, Gibala MJ: Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. J Physiol. 2008, 586 (1): 151-60. 10.1113/jphysiol.2007.142109.PubMedCentralCrossRefPubMed
28.
go back to reference Edge J, Bishop D, Goodman C, Dawson B: Effects of high- and moderate-intensity training on metabolism and repeated sprints. Med Sci Sports Exerc. 2005, 37 (11): 1975-82. 10.1249/01.mss.0000175855.35403.4c.CrossRefPubMed Edge J, Bishop D, Goodman C, Dawson B: Effects of high- and moderate-intensity training on metabolism and repeated sprints. Med Sci Sports Exerc. 2005, 37 (11): 1975-82. 10.1249/01.mss.0000175855.35403.4c.CrossRefPubMed
29.
go back to reference Gross M, Swensen T, King D: Nonconsecutive- versus consecutive-day high-intensity interval training in cyclists. Med Sci Sports Exerc. 2007, 39 (9): 1666-71. 10.1249/mss.0b013e3180cac209.CrossRefPubMed Gross M, Swensen T, King D: Nonconsecutive- versus consecutive-day high-intensity interval training in cyclists. Med Sci Sports Exerc. 2007, 39 (9): 1666-71. 10.1249/mss.0b013e3180cac209.CrossRefPubMed
30.
go back to reference Zoeller RF, Stout JR, O'Kroy JA, Torok DJ, Mielke M: Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion. Amino Acids. 2007, 33 (3): 505-10. 10.1007/s00726-006-0399-6.CrossRefPubMed Zoeller RF, Stout JR, O'Kroy JA, Torok DJ, Mielke M: Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion. Amino Acids. 2007, 33 (3): 505-10. 10.1007/s00726-006-0399-6.CrossRefPubMed
31.
go back to reference Preen D, Dawson B, Goodman C, Lawrence S, Beilby J, Ching S: Effect of creatine loading on long-term sprint exercise performance and metabolism. Med Sci Sports Exerc. 2001, 33 (5): 814-21.CrossRefPubMed Preen D, Dawson B, Goodman C, Lawrence S, Beilby J, Ching S: Effect of creatine loading on long-term sprint exercise performance and metabolism. Med Sci Sports Exerc. 2001, 33 (5): 814-21.CrossRefPubMed
32.
go back to reference van Loon LJ, Oosterlaar AM, Hartgens F, Hesselink MK, Snow RJ, Wagenmakers AJ: Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humans. Clin Sci (Lond). 2003, 104 (2): 153-62. 10.1042/CS20020159.CrossRef van Loon LJ, Oosterlaar AM, Hartgens F, Hesselink MK, Snow RJ, Wagenmakers AJ: Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humans. Clin Sci (Lond). 2003, 104 (2): 153-62. 10.1042/CS20020159.CrossRef
33.
go back to reference McNaughton LR, Dalton B, Tarr J: The effects of creatine supplementation on high-intensity exercise performance in elite performers. Eur J Appl Physiol Occup Physiol. 1998, 78 (3): 236-40. 10.1007/s004210050413.CrossRefPubMed McNaughton LR, Dalton B, Tarr J: The effects of creatine supplementation on high-intensity exercise performance in elite performers. Eur J Appl Physiol Occup Physiol. 1998, 78 (3): 236-40. 10.1007/s004210050413.CrossRefPubMed
34.
go back to reference MacDougall JD, Hicks AL, MacDonald JR, McKelvie RS, Green HJ, Smith KM: Muscle performance and enzymatic adaptations to sprint interval training. J Appl Physiol. 1998, 84 (6): 2138-42.PubMed MacDougall JD, Hicks AL, MacDonald JR, McKelvie RS, Green HJ, Smith KM: Muscle performance and enzymatic adaptations to sprint interval training. J Appl Physiol. 1998, 84 (6): 2138-42.PubMed
35.
go back to reference Hickson RC, Bomze HA, Holloszy JO: Linear increase in aerobic power induced by a strenuous program of endurance exercise. J Appl Physiol. 1977, 42 (3): 372-6.PubMed Hickson RC, Bomze HA, Holloszy JO: Linear increase in aerobic power induced by a strenuous program of endurance exercise. J Appl Physiol. 1977, 42 (3): 372-6.PubMed
36.
go back to reference Keith SP, Jacobs I, McLellan TM: Adaptations to training at the individual anaerobic threshold. Eur J Appl Physiol Occup Physiol. 1992, 65 (4): 316-23. 10.1007/BF00868134.CrossRefPubMed Keith SP, Jacobs I, McLellan TM: Adaptations to training at the individual anaerobic threshold. Eur J Appl Physiol Occup Physiol. 1992, 65 (4): 316-23. 10.1007/BF00868134.CrossRefPubMed
37.
go back to reference Rodas G, Ventura JL, Cadefau JA, Cusso R, Parra J: A short training programme for the rapid improvement of both aerobic and anaerobic metabolism. Eur J Appl Physiol. 2000, 82 (5-6): 480-6. 10.1007/s004210000223.CrossRefPubMed Rodas G, Ventura JL, Cadefau JA, Cusso R, Parra J: A short training programme for the rapid improvement of both aerobic and anaerobic metabolism. Eur J Appl Physiol. 2000, 82 (5-6): 480-6. 10.1007/s004210000223.CrossRefPubMed
38.
go back to reference Tabata I, Nishimura K, Kouzaki M, Hirai Y, Ogita F, Miyachi M, Yamamoto K: Effects of moderate-intensity endurance and high-intensity intermittent training on anaerobic capacity and VO2max. Med Sci Sports Exerc. 1996, 28 (10): 1327-30.CrossRefPubMed Tabata I, Nishimura K, Kouzaki M, Hirai Y, Ogita F, Miyachi M, Yamamoto K: Effects of moderate-intensity endurance and high-intensity intermittent training on anaerobic capacity and VO2max. Med Sci Sports Exerc. 1996, 28 (10): 1327-30.CrossRefPubMed
39.
go back to reference Ray CA: Sympathetic adaptations to one-legged training. J Appl Physiol. 1999, 86 (5): 1583-7.PubMed Ray CA: Sympathetic adaptations to one-legged training. J Appl Physiol. 1999, 86 (5): 1583-7.PubMed
40.
go back to reference Hoogeveen AR: The effect of endurance training on the ventilatory response to exercise in elite cyclists. Eur J Appl Physiol. 2000, 82 (1-2): 45-51. 10.1007/s004210050650.CrossRefPubMed Hoogeveen AR: The effect of endurance training on the ventilatory response to exercise in elite cyclists. Eur J Appl Physiol. 2000, 82 (1-2): 45-51. 10.1007/s004210050650.CrossRefPubMed
41.
go back to reference Linossier MT, Denis C, Dormois D, Geyssant A, Lacour JR: Ergometric and metabolic adaptation to a 5-s sprint training programme. Eur J Appl Physiol Occup Physiol. 1993, 67 (5): 408-14. 10.1007/BF00376456.CrossRefPubMed Linossier MT, Denis C, Dormois D, Geyssant A, Lacour JR: Ergometric and metabolic adaptation to a 5-s sprint training programme. Eur J Appl Physiol Occup Physiol. 1993, 67 (5): 408-14. 10.1007/BF00376456.CrossRefPubMed
42.
go back to reference Nelson AG, Day R, Glickman-Weiss EL, Hegsted M, Kokkonen J, Sampson B: Creatine supplementation alters the response to a graded cycle ergometer test. Eur J Appl Physiol. 2000, 83 (1): 89-94. 10.1007/s004210000244.CrossRefPubMed Nelson AG, Day R, Glickman-Weiss EL, Hegsted M, Kokkonen J, Sampson B: Creatine supplementation alters the response to a graded cycle ergometer test. Eur J Appl Physiol. 2000, 83 (1): 89-94. 10.1007/s004210000244.CrossRefPubMed
43.
go back to reference Reardon TF, Ruell PA, Fiatarone Singh MA, Thompson CH, Rooney KB: Creatine supplementation does not enhance submaximal aerobic training adaptations in healthy young men and women. Eur J Appl Physiol. 2006, 98 (3): 234-41. 10.1007/s00421-006-0267-9.CrossRefPubMed Reardon TF, Ruell PA, Fiatarone Singh MA, Thompson CH, Rooney KB: Creatine supplementation does not enhance submaximal aerobic training adaptations in healthy young men and women. Eur J Appl Physiol. 2006, 98 (3): 234-41. 10.1007/s00421-006-0267-9.CrossRefPubMed
44.
go back to reference Murphy AJ, Watsford ML, Coutts AJ, Richards DA: Effects of creatine supplementation on aerobic power and cardiovascular structure and function. J Sci Med Sport. 2005, 8 (3): 305-13. 10.1016/S1440-2440(05)80041-6.CrossRefPubMed Murphy AJ, Watsford ML, Coutts AJ, Richards DA: Effects of creatine supplementation on aerobic power and cardiovascular structure and function. J Sci Med Sport. 2005, 8 (3): 305-13. 10.1016/S1440-2440(05)80041-6.CrossRefPubMed
45.
go back to reference McConell GK, Shinewell J, Stephens TJ, Stathis CG, Canny BJ, Snow RJ: Creatine supplementation reduces muscle inosine monophosphate during endurance exercise in humans. Med Sci Sports Exerc. 2005, 37 (12): 2054-61. 10.1249/01.mss.0000179096.03129.a4.CrossRefPubMed McConell GK, Shinewell J, Stephens TJ, Stathis CG, Canny BJ, Snow RJ: Creatine supplementation reduces muscle inosine monophosphate during endurance exercise in humans. Med Sci Sports Exerc. 2005, 37 (12): 2054-61. 10.1249/01.mss.0000179096.03129.a4.CrossRefPubMed
46.
go back to reference Wasserman K, Beaver WL, Whipp BJ: Gas exchange theory and the lactic acidosis (anaerobic) threshold. Circulation. 1990, 81 (1 Suppl): II14-30.PubMed Wasserman K, Beaver WL, Whipp BJ: Gas exchange theory and the lactic acidosis (anaerobic) threshold. Circulation. 1990, 81 (1 Suppl): II14-30.PubMed
47.
go back to reference Wasserman K, Whipp BJ, Koyl SN, Beaver WL: Anaerobic threshold and respiratory gas exchange during exercise. J Appl Physiol. 1973, 35 (2): 236-43.PubMed Wasserman K, Whipp BJ, Koyl SN, Beaver WL: Anaerobic threshold and respiratory gas exchange during exercise. J Appl Physiol. 1973, 35 (2): 236-43.PubMed
48.
go back to reference Poole DC, Gaesser GA: Response of ventilatory and lactate thresholds to continuous and interval training. J Appl Physiol. 1985, 58 (4): 1115-21.PubMed Poole DC, Gaesser GA: Response of ventilatory and lactate thresholds to continuous and interval training. J Appl Physiol. 1985, 58 (4): 1115-21.PubMed
49.
go back to reference Acevedo EO, Goldfarb AH: Increased training intensity effects on plasma lactate, ventilatory threshold, and endurance. Med Sci Sports Exerc. 1989, 21 (5): 563-8.CrossRefPubMed Acevedo EO, Goldfarb AH: Increased training intensity effects on plasma lactate, ventilatory threshold, and endurance. Med Sci Sports Exerc. 1989, 21 (5): 563-8.CrossRefPubMed
50.
go back to reference Laursen PB, Blanchard MA, Jenkins DG: Acute high-intensity interval training improves Tvent and peak power output in highly trained males. Can J Appl Physiol. 2002, 27 (4): 336-48.CrossRefPubMed Laursen PB, Blanchard MA, Jenkins DG: Acute high-intensity interval training improves Tvent and peak power output in highly trained males. Can J Appl Physiol. 2002, 27 (4): 336-48.CrossRefPubMed
51.
go back to reference Balsom PD, Soderlund K, Sjodin B, Ekblom B: Skeletal muscle metabolism during short duration high-intensity exercise: influence of creatine supplementation. Acta Physiol Scand. 1995, 154 (3): 303-10. 10.1111/j.1748-1716.1995.tb09914.x.CrossRefPubMed Balsom PD, Soderlund K, Sjodin B, Ekblom B: Skeletal muscle metabolism during short duration high-intensity exercise: influence of creatine supplementation. Acta Physiol Scand. 1995, 154 (3): 303-10. 10.1111/j.1748-1716.1995.tb09914.x.CrossRefPubMed
52.
go back to reference Febbraio MA, Flanagan TR, Snow RJ, Zhao S, Carey MF: Effect of creatine supplementation on intramuscular TCr, metabolism and performance during intermittent, supramaximal exercise in humans. Acta Physiol Scand. 1995, 155 (4): 387-95. 10.1111/j.1748-1716.1995.tb09988.x.CrossRefPubMed Febbraio MA, Flanagan TR, Snow RJ, Zhao S, Carey MF: Effect of creatine supplementation on intramuscular TCr, metabolism and performance during intermittent, supramaximal exercise in humans. Acta Physiol Scand. 1995, 155 (4): 387-95. 10.1111/j.1748-1716.1995.tb09988.x.CrossRefPubMed
53.
go back to reference Volek JS, Kraemer WJ, Bush JA, Boetes M, Incledon T, Clark KL, Lynch JM: Creatine supplementation enhances muscular performance during high-intensity resistance exercise. J Am Diet Assoc. 1997, 97 (7): 765-70. 10.1016/S0002-8223(97)00189-2.CrossRefPubMed Volek JS, Kraemer WJ, Bush JA, Boetes M, Incledon T, Clark KL, Lynch JM: Creatine supplementation enhances muscular performance during high-intensity resistance exercise. J Am Diet Assoc. 1997, 97 (7): 765-70. 10.1016/S0002-8223(97)00189-2.CrossRefPubMed
54.
go back to reference Casey A, Constantin-Teodosiu D, Howell S, Hultman E, Greenhaff PL: Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans. Am J Physiol. 1996, 271 (1 Pt 1): E31-7.PubMed Casey A, Constantin-Teodosiu D, Howell S, Hultman E, Greenhaff PL: Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans. Am J Physiol. 1996, 271 (1 Pt 1): E31-7.PubMed
55.
go back to reference Tarnopolsky MA, MacLennan DP: Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Int J Sport Nutr Exerc Metab. 2000, 10 (4): 452-63.PubMed Tarnopolsky MA, MacLennan DP: Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Int J Sport Nutr Exerc Metab. 2000, 10 (4): 452-63.PubMed
56.
go back to reference Jager R, Metzger J, Lautmann K, Shushakov V, Purpura M, Geiss KR, Maassen N: The effects of creatine pyruvate and creatine citrate on performance during high intensity exercise. J Int Soc Sports Nutr. 2008, 5 (4): Jager R, Metzger J, Lautmann K, Shushakov V, Purpura M, Geiss KR, Maassen N: The effects of creatine pyruvate and creatine citrate on performance during high intensity exercise. J Int Soc Sports Nutr. 2008, 5 (4):
Metadata
Title
The effects of four weeks of creatine supplementation and high-intensity interval training on cardiorespiratory fitness: a randomized controlled trial
Authors
Jennifer L Graef
Abbie E Smith
Kristina L Kendall
David H Fukuda
Jordan R Moon
Travis W Beck
Joel T Cramer
Jeffrey R Stout
Publication date
01-12-2009
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1550-2783-6-18

Other articles of this Issue 1/2009

Journal of the International Society of Sports Nutrition 1/2009 Go to the issue